Trial of Nivolumab With Chemotherapy as Neoadjuvant Treatment in Inflammatory Breast Cancer (IBC)

PHASE2CompletedINTERVENTIONAL
Enrollment

8

Participants

Timeline

Start Date

May 2, 2019

Primary Completion Date

June 12, 2023

Study Completion Date

June 12, 2023

Conditions
Breast Cancer
Interventions
DRUG

Nivolumab 360mg

Nivolumab 360 mg IV on Day 1 of every 21 day cycle (Cycle 1-4)

DRUG

Paclitaxel 80mg/m^2

Paclitaxel 80mg/m\^2 IV on Day of 1, 8, 15 of every 21 day cycle (Cycle 1-4)

DRUG

Doxorubicin 60mg/m^2

Doxorubicin 60 mg/m\^2 IV on Day 1 of every 14 day cycle (Cycle 5-8)

DRUG

Cyclophosphamide 600mg/m^2

Cyclophosphamide 600mg/m\^2 on Day 1 of every 14 day cycle (Cycle 5-8)

DRUG

Paclitaxel 80mg/m^2 or Docetaxel 75mg/m^2

Paclitaxel 80mg/m\^2 on Day 1, 8, 15 of every 21 day cycle (Cycle 1-4) OR Docetaxel 75mg/m\^2 on Day 1 of every 21 day cycle (Cycle 1-4)

DRUG

Trastuzumab 8mg/kg and 6 mg/kg

Trastuzumab 8mg/kg IV on Day 1 of Cycle 1 and then 6mg/kg IV on Day 1 of Cycle 2-4

DRUG

Pertuzumab 840mg and 420mg

Pertuzumab 840mg on Day 1 of Cycle 1 and then 420mg IV on Day 1 of Cycle 2-4

Trial Locations (2)

10016

NYU Langone Health, New York

47405

Indiana University, Bloomington

All Listed Sponsors
lead

NYU Langone Health

OTHER

NCT03742986 - Trial of Nivolumab With Chemotherapy as Neoadjuvant Treatment in Inflammatory Breast Cancer (IBC) | Biotech Hunter | Biotech Hunter