Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

390

Participants

Timeline

Start Date

December 12, 2018

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
Advanced Solid Neoplasms
Interventions
DRUG

Olaparib

Olaparib 300 mg administered BID as two, 150 mg oral tablets.

Trial Locations (130)

1211

Hopitaux Universitaires de Geneve HUG. ( Site 1406), Geneva

2010

Kinghorn Cancer Centre ( Site 2200), Darlinghurst

2100

Rigshospitalet ( Site 0402), Copenhagen

2444

MNCCI Port Macquarie Base Hospital ( Site 2201), Port Macquarie

2730

Herlev og Gentofte Hospital. ( Site 0401), Herlev

5000

Odense Universitetshospital ( Site 0400), Odense

6009

Linear Clinical Research Ltd ( Site 2202), Nedlands

6500

Ospedale Regionale di Bellinzona e Valli ( Site 1407), Bellinzona

8091

Universitaetsspital Zuerich ( Site 1400), Zuerich

10010

VA New York Harbor Healthcare System Manhattan ( Site 0094), New York

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0057), New York

10065

Memorial Sloan Kettering Cancer Center ( Site 0026), New York

10604

Memorial Sloan-Kettering Cancer Center at West Harrison ( Site 0126), Harrison

13006

Hospital de Alta Complejidad de La Libertad Virgen de La Puerta ( Site 3102), Trujillo

13620

Seoul National University Bundang Hospital ( Site 2402), Seongnam-si

15033

Hospital Nacional Guillermo Almenara Irigoyen ( Site 3107), Lima

15036

Clinica Internacional Sede San Borja ( Site 3100), Lima

Instituto de Oncologia y Radioterapia Clinica Ricardo Palma ( Site 3101), Lima

Oncosalud-Clinical Research ( Site 3108), Lima

15038

Instituto Nacional de Enfermedades Neoplasicas ( Site 3106), Lima

15046

Hospital Central de la Fuerza Aerea del Peru ( Site 3104), Lima

15076

Hospital Militar Central Coronel Luis Arias Schereiber ( Site 3105), Lima

15082

Hospital Arzobispo Loayza ( Site 3103), Lima

19124

Eastern Regional Medical Center, Inc. ( Site 0077), Philadelphia

20089

Istituto Clinico Humanitas Research Hospital ( Site 0703), Rozzano

21000

Centre Georges Francois Leclerc ( Site 0608), Dijon

21201

University of Maryland ( Site 0050), Baltimore

21237

Weinberg Cancer Institute at Franklin Square ( Site 0054), Baltimore

22030

Trakya Universitesi Tip Fakultesi ( Site 1500), Edirne

28223

Hospital Universitario Quiron Madrid ( Site 1352), Pozuelo de Alarcón

30912

Augusta University ( Site 0028), Augusta

31000

Centro Estatal de Cancerologia de Chihuahua ( Site 2907), Chihuahua City

33076

Institut Bergonie ( Site 0603), Bordeaux

34098

Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 1505), Istanbul

34722

Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 1506), Istanbul

35100

Ege Universitesi Tip Fakultesi ( Site 1502), Izmir

40536

Markey Cancer Center ( Site 0018), Lexington

42080

Necmettin Erbakan Universitesi Meram Tip Fakultesi ( Site 1507), Konya

44680

Actualidad Basada en la Investigacion del Cancer ( Site 2903), Guadalajara

48202

Henry Ford Health System ( Site 0060), Detroit

53100

Policlinico Le Scotte di Siena ( Site 0704), Siena

57104

Sanford Hematology Oncology-Sioux Falls SD ( Site 0012), Sioux Falls

64460

Unidad Biomedica Avanzada Monterrey S. A. ( Site 2902), Monterrey

67033

Institut de Cancerologie Strasbourg Europe ( Site 0613), Strasbourg

68000

Oaxaca Site Management Organization S.C. ( Site 2905), Oaxaca City

68510

Cancer Partners of Nebraska ( Site 0051), Lincoln

74133

Southwestern Regional Medical Center, Inc. ( Site 0079), Tulsa

76000

Cuidados Oncologicos ( Site 2908), Santiago de Quetaro

80045

Rocky Mountain Regional Veterans Affairs Medical Center ( Site 0092), Aurora

80131

Istituto Nazionale Tumori Fondazione Pascale ( Site 0700), Napoli

84790

Intermountain Healthcare ( Site 0043), St. George

85719

The University of Arizona Cancer Center - North Campus ( Site 0011), Tucson

86021

CHU Poitiers ( Site 0612), Poitiers

89440

Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 2901), Madero

90048

Cedars Sinai Medical Center ( Site 0002), Los Angeles

92835

St Joseph Heritage Healthcare-Oncology ( Site 0056), Fullerton

94158

UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0007), San Francisco

94805

Institut Gustave Roussy ( Site 0601), Villejuif

98101

Virginia Mason Medical Center ( Site 0052), Seattle

98108

Veterans Affairs Puget Sound Health Care System [Seattle, WA] ( Site 0093), Seattle

110221

Administradora Country SA - Clinica del Country ( Site 2802), Bogotá

110311

Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 2807), Bogotá

111511

Instituto Nacional de Cancerologia E.S.E ( Site 2809), Bogotá

115477

N.N. Blokhin NMRCO ( Site 1201), Moscow

125284

MSROI named after P.A. Hertsen branch of FSBI NMRC Radiology ( Site 1213), Moscow

143442

MEDSI Clinical Hospital on Pyatnitsky Highway-Departmentof Antitumor Drug therapy ( Site 1216), Krasnogorsk

163045

Arkhangelsk Clinical Oncological Dispensary ( Site 1204), Arkhangelsk

194044

Clinical Hospital Saint Luka ( Site 1205), Saint Petersburg

194291

SBHI Leningrad Regional Clinical Hospital ( Site 1206), Saint Petersburg

197758

Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1208), Saint Petersburg

200001

Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 2808), Valledupar

200542

S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 1103), Craiova

230002

Oncomedica S.A. ( Site 2806), Montería

390011

Ryazan Regional Clinical Oncology dispensary ( Site 1202), Ryazan

400641

Medisprof ( Site 1107), Cluj-Napoca

407280

SC Radiotherapy Center Cluj SRL ( Site 1105), Comuna Floresti

410469

S.C. Pelican Impex S.R.L Spitalul Clinic Pelican Oradea ( Site 1102), Oradea

420029

Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 120, Kazan'

443031

SBHI Samara Regional Clinical Oncology Dispensary ( Site 1211), Samara

454087

Chelyabinsk Regional Clinical Oncological Dispensary ( Site 1212), Chelyabinsk

500152

Spitalul PDR Medlife ( Site 1106), Brasov

760042

C. Medico Imbanaco Cali S.A. ( Site 2810), Santiago de Cali

2778577

National Cancer Center Hospital East ( Site 2600), Kashiwa

3109601

Rambam Health Care Campus-Oncology Division ( Site 0801), Haifa

5262000

Chaim Sheba Medical Center ( Site 0803), Ramat Gan

6423906

Sourasky Medical Center ( Site 0804), Tel Aviv

8457108

Soroka Medical Center ( Site 0800), Beersheba

9112001

Hadassah Ein Kerem Medical Center ( Site 0802), Jerusalem

30322-1013

Winship Cancer Institute of Emory University ( Site 0025), Atlanta

01655

University of Massachusetts ( Site 0017), Worcester

07748

Memorial Sloan Kettering Cancer Center- Monmouth ( Site 0116), Middletown

B1884BBF

Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 2703), Berazategui

C1280AEB

Hospital Britanico de Buenos Aires ( Site 2704), Ciudad de Buenos Aires

C1012AAR

Instituto de Investigaciones Metabolicas ( Site 2700), Buenos Aires

C1118AAT

Hospital Aleman ( Site 2702), Buenos Aires

M4N 3M5

Sunnybrook Research Institute ( Site 0210), Toronto

H1T 2M4

Hopital Maisonneuve-Rosemont CIUSSS de l Est de L Ile de Montreal ( Site 0203), Montreal

H3T 1E2

Jewish General Hospital ( Site 0209), Montreal

G1J 1Z4

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0, Québec

050021

Fundacion Centro de Investigacion Clinica CIC ( Site 2812), Medellín

050030

Rodrigo Botero SAS ( Site 2801), Medellín

080001

Biomelab S A S ( Site 2800), Barranquilla

06189

Centre Antoine Lacassagne ( Site 0610), Nice

09001

Centro Regional de Sub Especialidades Medicas SA ( Site 3003), Guatemala

01010

Centro de Investigaciones Clinicas de Latinoamerica S.A. - CELAN ( Site 3004), Guatemala City

Integra Cancer Institute ( Site 3006), Guatemala City

01015

Grupo Angeles SA ( Site 3001), Guatemala City

D07 WKW8

Mater Misericordiae University Hospital ( Site 1654), Dublin

T12 DV56

Bon Secours Hospital ( Site 1656), Cork

00004

St. Vincent's University Hospital ( Site 1653), Dublin

D24 NROA

Tallaght University Hospital ( Site 1652), Dublin

464-8681

Aichi Cancer Center Hospital ( Site 2602), Nagoya

606-8507

Kyoto University Hospital ( Site 2603), Kyoto

565-0871

Osaka University Hospital ( Site 2604), Suita

104-0045

National Cancer Center Hospital ( Site 2601), Tokyo

135-8550

The Cancer Institute Hospital of JFCR ( Site 2605), Tokyo

06100

CRYPTEX Investigacion Clinica S.A. de C.V. ( Site 2900), Mexico City

Hacettepe Universitesi Tıp Fakultesi ( Site 1503), Ankara

03100

CENEIT Oncologicos ( Site 2904), México

022548

S.C.Focus Lab Plus S.R.L ( Site 1101), Bucharest

031422

S.C.Gral Medical S.R.L ( Site 1104), Bucharest

03080

Seoul National University Hospital ( Site 2401), Seoul

03722

Severance Hospital Yonsei University Health System ( Site 2400), Seoul

08035

Hospital Universitari Vall d Hebron ( Site 1350), Barcelona

01250

Baskent University Adana Training Hospital ( Site 1508), Adana

07070

Akdeniz Universitesi Tip Fakultesi ( Site 1504), Antalya

OX3 7LE

Churchill Hospital ( Site 1606), Oxford

M20 4BX

Christie NHS Foundation Trust ( Site 1601), Manchester

NE7 7DN

Northern Centre for Cancer Care ( Site 1602), Newcastle upon Tyne

S10 2SJ

Weston Park Hospital ( Site 1607), Sheffield

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY