Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,367

Participants

Timeline

Start Date

December 18, 2018

Primary Completion Date

August 26, 2024

Study Completion Date

May 29, 2026

Conditions
Ovarian CancerFallopian Tube CancerPeritoneal Neoplasms
Interventions
BIOLOGICAL

Pembrolizumab

IV infusion

DRUG

Placebo for pembrolizumab

IV infusion

DRUG

Carboplatin

IV infusion

DRUG

Paclitaxel

IV infusion

DRUG

Olaparib

Oral tablet

DRUG

Placebo for olaparib

Oral tablet

BIOLOGICAL

Bevacizumab

IV infusion

DRUG

Docetaxel

IV infusion

Trial Locations (227)

333

Linkou Chang Gung Memorial Hospital ( Site 2501), Taoyuan District

704

National Cheng Kung University Hospital ( Site 2508), Tainan City

1051

Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz ( Site 0802), Miskolc

1122

Orszagos Onkologiai Intezet ( Site 0800), Budapest

1145

Uzsoki Utcai Korhaz ( Site 0803), Budapest

1200

Cliniques Universitaires Saint-Luc ( Site 0312), Brussels

1932

Imelda Ziekenhuis Bonheiden ( Site 0301), Bonheiden

2193

Wits Clinical Research ( Site 1702), Johannesburg

2196

Sandton Oncology Medical Group PTY LTD ( Site 1712), Sandton

2217

St George Hospital ( Site 2207), Kogarah

3000

UZ Leuven Campus Gasthuisberg ( Site 0306), Leuven

3021

Sunshine Hospital. ( Site 2205), St Albans

3168

Monash Health ( Site 2204), Clayton

3350

Ballarat Health Services ( Site 2202), Ballarat

3500

Jessa Ziekenhuis ( Site 0309), Hasselt

4000

CHU de Liege ( Site 0310), Liège

4032

Debreceni Egyetem Klinikai Kozpont ( Site 0801), Debrecen

4091

The Oncology Centre ( Site 1709), Durban

4870

Cairns and Hinterland Hospital and Health Service ( Site 2201), Cairns

6000

Grand Hopital de Charleroi ( Site 0302), Charleroi

6045

Cancer Care Langenhoven Drive Oncology Centre ( Site 1701), Port Elizabeth

6530

Outeniqua Cancercare Oncology Unit ( Site 1708), George

6800

Centre Hospitalier de l'Ardenne ( Site 0303), Libramont

7570

Cape Town Oncology Trials Pty Ltd ( Site 1707), Kraaifontein

7624

Pecsi Tudomanyegyetem Klinikai Kozpont ( Site 0805), Pécs

7700

Cancercare ( Site 1706), Cape Town

7925

Groote Schuur Hospital ( Site 1704), Cape Town

9000

AZ Maria Middelares Gent ( Site 0300), Ghent

UZ Gent ( Site 0307), Ghent

10002

National Taiwan University Hospital ( Site 2502), Taipei

10003

Hospital Provincial San Pedro de Alcantara ( Site 1607), Cáceres

10126

A.O.U. Citta della Salute e della Scienza di Torino ( Site 1104), Turin

10449

MacKay Memorial Hospital ( Site 2500), Taipei

11042

Northwell Health- Monter Cancer Center ( Site 0075), Lake Success

11217

Taipei Veterans General Hospital ( Site 2503), Taipei

13005

Hopital de la Timone ( Site 0617), Marseille

13353

Charite Campus Virchow-Klinikum - CVK ( Site 0700), Berlin

13620

Seoul National University Bundang Hospital ( Site 2404), Seongnam-si

15006

Complejo Hospitalario Universitario A Coruna. CHUAC ( Site 1608), A Coruña

16059

Uludag Universitesi Tip Fakultesi ( Site 1904), Bursa

20014

Hospital Universitario de Donostia ( Site 1602), Donostia / San Sebastian

20133

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1115), Milan

20141

Istituto Europeo di Oncologia ( Site 1100), Milan

20155

Virginia Cancer Specialists, PC ( Site 8003), Gainesville

21237

Weinberg Cancer Institute at Franklin Square ( Site 0035), Baltimore

23900

ASST Lecco. Ospedale A. Manzoni ( Site 1101), Lecco

24116

Staedtisches Krankenhaus Kiel GmbH ( Site 0709), Kiel

27003

Hospital Universitario Lucus Augusti ( Site 1609), Lugo

28027

Clinica Universitaria de Navarra ( Site 1600), Madrid

29009

Municipal non-profit Enterprise Khmelnytskyi Regional Antitu-Gynecological Oncology department, Poli, Khmelnytskyi

29200

CHU de Brest -Site Hopital Morvan ( Site 0616), Brest

30029

Institut de Cancerologie du Gard - CHU Caremeau ( Site 0610), Nîmes

30322

Emory School of Medicine ( Site 0053), Atlanta

30501

Northeast Georgia Medical Center ( Site 0029), Gainesville

31404

Memorial Health University Medical Center ( Site 0011), Savannah

33100

A.O. Univ. S. M. della Misericordia ( Site 1114), Udine

34093

Istanbul Universitesi Istanbul Tip Fakultesi ( Site 1900), Istanbul

34147

Bakirkoy Sadi Konuk Egitim ve Arastirma Hastanesi ( Site 1907), Istanbul

34214

Medipol Universite Hastanesi ( Site 1909), Istanbul

34239

Sarasota Memorial Hospital ( Site 0023), Sarasota

34303

Istanbul Acibadem University Atakent Hospital ( Site 1902), Küçükçekmece

35128

Istituto Oncologico Veneto IRCCS ( Site 1113), Padua

35233

University of Alabama at Birmingham (UAB) ( Site 0036), Birmingham

38122

Presidio Ospedaliero Santa Chiara ( Site 1109), Trento

39216

Saint Dominic - Jackson Memorial Hospital ( Site 0072), Jackson

40022

RMI - Sumy Regional Clinical Oncology Dispensary ( Site 2191), Sumy

40225

Universitaetsklinikum Duesseldorf ( Site 0704), Düsseldorf

40447

China Medical University Hospital ( Site 2506), Taichung

40536

University of Kentucky ( Site 0045), Lexington

40705

Taichung Veterans General Hospital ( Site 2510), Taichung

41013

Hospital Universitario Virgen del Rocio ( Site 1604), Seville

42270

Institut de Cancerologie Lucien Neuwirth ( Site 0613), Saint-Priest-en-Jarez

43026

OSU Wexner Medical Center ( Site 0076), Hilliard

43214

The Bing Cancer Center ( Site 0044), Columbus

44137

Klinikum Dortmund gGmbH ( Site 0717), Dortmund

45242

Oncology/Hematology Care Clinical Trials, LLC ( Site 8001), Cincinnati

45459

Miami Valley Hospital [Dayton, OH] ( Site 0073), Centerville

46009

Instituto Valenciano de Oncologia ( Site 1601), Valencia

46014

Hospital General Universitario de Valencia ( Site 1610), Valencia

46260

Saint Vincent Hospital and Health Center ( Site 0012), Indianapolis

47805

HELIOS Klinikum Krefeld ( Site 0715), Krefeld

48149

Universitaetsklinikum Muenster ( Site 0720), Münster

50006

Changhua Christian Hospital ( Site 2507), Changhua

52074

Uniklinik RWTH Aachen ( Site 0718), Aachen

52242

University of Iowa Hospital and Clinics ( Site 0005), Iowa City

53111

Gynaekologisches Zentrum ( Site 0712), Bonn

53226

MEDICAL COLLEGE OF WISCONSIN ( Site 0064), Milwaukee

54100

Centre D Oncologie de Gentilly ( Site 0609), Nancy

54290

Sakarya Universitesi Tip Fakultesi Hastanesi ( Site 1906), Sakarya

57104

Sanford Gynecology Oncology ( Site 0004), Sioux Falls

58122

Sanford Roger Maris Cancer Center ( Site 0082), Fargo

60521

Dr. Sudarshan K. Sharma, LTD ( Site 0061), Hinsdale

60612

Rush University Medical Center ( Site 0019), Chicago

60637

University of Chicago ( Site 0049), Chicago

61024

Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2180), Kharkiv

63110

Washington University - School of Medicine ( Site 0062), St Louis

65055

MI Odessa Regional Oncological Centre ( Site 2121), Odesa

66113

Caritas Klinikum Saarbruecken St. Theresia ( Site 0702), Saarbrücken

67065

Centre Paul Strauss ( Site 0615), Strasbourg

68114

Nebraska Methodist Hospital ( Site 0063), Omaha

69008

Hopital Prive Jean Mermoz ( Site 0607), Lyon

70124

IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 1108), Bari

70199

Marienhospital Stuttgart Vincenz von Paul Kliniken gGmbH ( Site 0707), Stuttgart

72074

Klinikum Rechts der Isar. Technischen Universitaet Muenchen ( Site 0710), Munich

75020

Hopital Tenon ( Site 0612), Paris

75231

Texas Oncology-Dallas Presbyterian Hospital ( Site 8004), Dallas

75235

Parkland Hospital ( Site 0081), Dallas

75390

UT Southwestern Medical Center ( Site 0046), Dallas

75702

Texas Oncology, P.A. Texas Oncology-Tyler ( Site 8006), Tyler

76018

MI Precarpathian Clinical Oncology Center ( Site 2181), Ivano-Frankivsk

76022

Texas Oncology, P.A. - Bedford ( Site 8005), Bedford

79031

Lviv State Oncology Regional Treatment and Diagnostic Center ( Site 2170), Lviv

80131

A.O.U. Federico II di Napoli ( Site 1107), Napoli

82100

Sacro Cuore di Gesu Fatebenefratelli ( Site 1112), Benevento

85719

University of Arizona Cancer Center ( Site 0074), Tucson

88000

Central City Clinical Hospital ( Site 2150), Uzhhorod

91505

Disney Family Cancer Center ( Site 0042), Burbank

94115

Kaiser Permanente Oncology Clinical Trial - San Francisco ( Site 0078), San Francisco

94589

Kaiser Permanente N. CA Regional Oncology Clinical Trials ( Site 0008), Vallejo

94596

Kaiser Permanente Oncology Clinical Trial - Walnut Creek ( Site 0080), Walnut Creek

94611

Kaiser Permanente Oncology Clinical Trial -Oakland ( Site 0077), Oakland

94800

Institut Gustave Roussy ( Site 0600), Villejuif

95051

Kaiser Permanente Oncology Clinical Trial - Santa Clara ( Site 0079), Santa Clara

95126

Ospedale Cannizzaro ( Site 1110), Catania

95661

Kaiser Permanente Oncology Clinical Trials-Roseville ( Site 0084), Roseville

95814

Kaiser Permanente Oncology Clinical Trials-Sacramento ( Site 0083), Sacramento

110321

Instituto Nacional de Cancerologia E.S.E ( Site 2910), Bogotá

111321

Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 2912), Bogotá

115478

FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 1500), Moscow

115682

FSCC of Special Types of Med. Care and Technologies ( Site 1503), Moscow

125367

Medical Rehabilitation Center ( Site 1502), Moscow

163045

Arkhangelsk Clinical Oncological Dispensary ( Site 1508), Arkhangelsk

197758

National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 1504), Saint Petersburg

198255

City Clinical Oncology Center ( Site 1505), Saint Petersburg

200001

Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 2913), Valledupar

230002

Oncomedica S.A. ( Site 2911), Montería

249036

A. Tsyb Medical Radiological Research Center ( Site 1513), Obninsk

420029

Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1509), Kazan'

450054

Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1507), Ufa

760042

Centro Medico Imbanaco de Cali S.A ( Site 2909), Santiago de Cali

Hemato Oncologos S.A. ( Site 2906), Santiago de Cali

1240000

Centro Oncologico Antofagasta ( Site 2804), Antofagasta

2520598

Oncocentro ( Site 2801), Viña del Mar

3436212

Carmel Medical Center ( Site 1007), Haifa

3525408

Rambam Medical Center ( Site 1002), Haifa

3810101

Hillel Yaffe Medical Center ( Site 1011), Hadera

4780000

Centro Investigación del Cáncer James Lind ( Site 2810), Temuco

4810218

Centro de Investigacion y desarrollo Oncologico SpA - CIDO SpA ( Site 2808), Temuco

4941492

Rabin Medical Center ( Site 1004), Petah Tikva

5262000

Chaim Sheba Medical Center ( Site 1000), Ramat Gan

5822012

Edith Wolfson Medical Center ( Site 1003), Holon

6423906

Sourasky Medical Center ( Site 1001), Tel Aviv

7500922

Fundacion Arturo Lopez Perez FALP ( Site 2800), Santiago

7510032

Sociedad Oncovida S.A. ( Site 2807), Santiago

7630370

Iram Cancer Research ( Site 2809), Santiago

8330032

Pontificia Universidad Catolica de Chile ( Site 2805), Santiago

8410101

Soroka Medical Center ( Site 1006), Beersheba

9103102

Shaare Zedek Medical Center ( Site 1005), Jerusalem

06511

Smilow Cancer Center at Yale-New Haven ( Site 0057), New Haven

03756

Dartmouth Hitchcock Medical Center ( Site 0024), Lebanon

08103

MD Anderson Cancer Center at Cooper ( Site 0067), Camden

07666

Holy Name Medical Center ( Site 0037), Teaneck

02905

Women and Infants Hospital [Providence, RI] ( Site 0039), Providence

60430-230

Instituto do Cancer do Ceara ( Site 2707), Fortaleza

74605-070

Hospital Araujo Jorge Associacao de Combate ao Cancer de Goias ( Site 2708), Goiânia

82520-060

Hospital Erasto Gaertner ( Site 2716), Curitiba

98700-000

Hospital de Caridade de Ijui ( Site 2712), Ijuí

95900-000

Hospital Bruno Born ( Site 2704), Lajeado

91350-200

Hospital Nossa Senhora Da Conceicao ( Site 2703), Porto Alegre

20220-410

Instituto Nacional de Cancer Hospital do Cancer II ( Site 2700), Rio de Janeiro

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 2714), São Paulo

01317-000

Clinica de Pesquisas e Ctro de Estudos Onc. Ginecol. e Mamaria Ltda ( Site 2706), São Paulo

01321-001

Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 2710), São Paulo

T2N 4N2

Tom Baker Cancer Centre ( Site 0200), Calgary

K7L 2V7

Kingston Health Sciences Centre ( Site 0207), Kingston

L5M 2N1

The Credit Valley Hospital ( Site 0206), Mississauga

M5G 2M9

Princess Margaret Hospital.. ( Site 0202), Toronto

G7H 5H6

CIUSSS du Saguenay-Lac-St-Jean ( Site 0218), Chicoutimi

H1T 2M4

CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0219), Montreal

H2X 0A9

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0208), Montreal

H4A 3J1

Royal Victoria Hospital McGill University Health Centre ( Site 0211), Montreal

080002

Biomelab S A S ( Site 2900), Barranquilla

602 00

Fakultni nemocnice Brno ( Site 0404), Brno

708 52

Fakultni nemocnice Ostrava ( Site 0403), Ostrava-Poruba

120 00

Vseobecna fakultni nemocnice v Praze ( Site 0400), Prague

180 81

Nemocnice Na Bulovce ( Site 0401), Prague

779 00

Fakultni nemocnice Olomouc ( Site 0402), Olomouc

09116

Klinikum Chemnitz gGmbH ( Site 0711), Chemnitz

00161

Azienda Ospedaliera Policlinico Umberto I ( Site 1111), Roma

00168

Policlinico Universitario Gemelli ( Site 1105), Roma

277-8577

National Cancer Center Hospital East ( Site 2602), Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center ( Site 2601), Matsuyama

791-0295

Ehime University Hospital ( Site 2600), Tōon

373-8550

Gunma Prefectural Cancer Center ( Site 2609), Ōta

060-8648

Hokkaido University Hospital ( Site 2607), Sapporo

028-3695

Iwate Medical University Hospital ( Site 2606), Shiwa-gun

216-8511

St. Marianna University School of Medicine Hospital ( Site 2613), Kawasaki

903-0215

University of the Ryukyus Hospital ( Site 2616), Nakagami-gun

350-1298

Saitama Medical University International Medical Center ( Site 2604), Hidaka

362-0806

Saitama Cancer Center ( Site 2614), Kitaadachi-gun

359-8513

National Defense Medical College Hospital ( Site 2608), Tokorozawa

181-8611

Kyorin University Hospital ( Site 2610), Mitaka

890-8760

Kagoshima City Hospital ( Site 2612), Kagoshima

951-8566

Niigata Cancer Center Hospital ( Site 2618), Niigata

541-8567

Osaka International Cancer Institute ( Site 2617), Osaka

104-0045

National Cancer Center Hospital ( Site 2605), Tokyo

61-848

Szpital Kliniczny im. Przemienienia Panskiego Uniwersytetu Medycznego im. K. Marcinkowskiego w Pozna, Poznan

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (, Warsaw

15-027

Bialostockie Centrum Onkologii ( Site 1412), Bialystok

81-519

Szpitale Pomorskie Sp. z o.o. ( Site 1407), Gdynia

44-102

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1406), Gliwice

25-734

Swietokrzyskie Centrum Onkologii SPZOZ ( Site 1410), Kielce

0002

Department of Medical Oncology ( Site 1703), Pretoria

0031

Curo Oncology ( Site 1710), Pretoria

0081

Wilgers Oncology Centre ( Site 1705), Pretoria

0181

Little Company of Mary Hospital ( Site 1700), Pretoria

03080

Seoul National University Hospital ( Site 2403), Seoul

03722

Severance Hospital Yonsei University Health System ( Site 2400), Seoul

05505

Asan Medical Center ( Site 2402), Seoul

06351

Samsung Medical Center ( Site 2401), Seoul

08909

Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 1603), L'Hospitalet de Llobregat

08243

Xarxa Assistencial Universitaria Manresa ( Site 1605), Manresa

08227

Hospital de Terrassa ( Site 1606), Terrassa

06050

Etlik Zubeyde Hanim Kadin Hastaliklari Egitim ve Arastirma Hastanesi ( Site 1903), Ankara

06590

Ankara UTF Cebeci Arastırma ve Uygulama Hastanesi ( Site 1905), Ankara

07070

Akdeniz Universitesi Tıp Fakultesi ( Site 1901), Antalya

03115

Kyiv City Clinical Oncological Center ( Site 2140), Kyiv

All Listed Sponsors
collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

collaborator

Gynecologic Oncology Group

NETWORK

lead

Merck Sharp & Dohme LLC

INDUSTRY