A Study to Compare Safety and Efficacy of Upadacitinib to Dupilumab in Adult Participants With Moderate to Severe Atopic Dermatitis

PHASE3CompletedINTERVENTIONAL
Enrollment

673

Participants

Timeline

Start Date

February 21, 2019

Primary Completion Date

August 27, 2020

Study Completion Date

December 9, 2020

Conditions
Atopic Dermatitis
Interventions
BIOLOGICAL

Upadacitinib

Extended release tablet

BIOLOGICAL

Dupilumab

Dupilumab is administered as a subcutaneous (SC) injection

DRUG

Placebo to dupilumab

Placebo administered as a subcutaneous injection

DRUG

Placebo to upadacitinib

Tablet

Trial Locations (159)

100

National Taiwan University Hospital /ID# 208309, Taipei City

116

Taipei Municipal Wan Fang Hospital /ID# 209987, Taipei

1010

Optimal Clinical Trials Ltd /ID# 209475, Auckland

1135

Uno Medical Trials Kft /ID# 211177, Budapest XIII

2010

Holdsworth House Medical Practice /ID# 214565, Darlinghurst

The Skin Hospital /ID# 214401, Darlinghurst

3002

Sinclair Dermatology /ID# 209395, East Melbourne

3206

Clinical Trials NZ /ID# 215590, Hamilton

4032

Debreceni Egyetem Klinikai Kozpont /ID# 210893, Debrecen

4102

Veracity Clinical Research /ID# 211134, Woolloongabba

5900

Oroshazi Korhaz /ID# 210150, Orosháza

6021

Wellington Hospital (Capital and Coast District Health Board) /ID# 215001, Wellington

6100

Burswood Dermatology /ID# 214875, Victoria Park

7006

St. Olavs Hospital HF /ID# 209137, Trondheim

7400

Somogy Megyei Kaposi Mor Oktat /ID# 210149, Kaposvár

7624

Pecsi Tudomanyegyetem Klinikai l.sz. Belgyogyaszati Klinika /ID# 210892, Pécs

9019

Universitetssykehuset N-Norge, Tromso /ID# 209103, Tromsø

9124

Ospedale San Giovanni di Dio /ID# 209109, Cagliari

9406

Universitetssykehuset N-Norge, Harstad /ID# 209105, Harstad

10000

DermaPlus - Poliklinika za dermatologiju i venerologiju /ID# 209935, Zagreb

Djecja bolnica Srebrnjak /ID# 209939, Zagreb

Klinicki bolnicki centar Zagreb /ID# 209976, Zagreb

10310

Naftalan - Specijalna bolnica za medicinsku rehabilitaciju /ID# 209937, Ivanić-Grad

10450

Hospital Pulau Pinang /ID# 210212, George Town

10467

Montefiore Medical Center /ID# 209647, The Bronx

11415

Forest Hills Dermatology Group /ID# 209249, Kew Gardens

13385

Hopital de la Timone /ID# 211245, Marseille

15831

Gemeinschaftspraxis /ID# 211174, Blankenfeld-mahlow

20089

IBD Center - IRCCS Istituto Clinico Humanitas /ID# 215726, Rozzano

20100

Pihlajalinna Turku /ID# 209599, Turku

20122

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 210632, Milan

25123

A.O.U. di Brescia /ID# 209115, Brescia

25309

West Virginia Research Inst /ID# 212730, South Charleston

27157

Wake Forest Univ HS /ID# 208892, Winston-Salem

29425

Medical University of South Carolina /ID# 211054, Charleston

30625

Medizinische Hochschule Hannover /ID# 210939, Hanover

31059

Hopital Larrey - CHU de Toulouse /ID# 208976, Toulouse

32127

Progressive Medical Research /ID# 211994, Port Orange

33028

"ME Rivne Regional Dermatology and Venereology Dispensary of RRC /ID# 210434", Rivne

33173

Florida International Rsrch cr /ID# 211562, Miami

33607

Clinical Research Trials of Florida, Inc. /ID# 210751, Tampa

33705

GCP Research /ID# 216020, St. Petersburg

35010

Hospital Universitario Dr. Negrin /ID# 208969, Las Palmas de Gran Canaria

36071

Complejo Hospitalario Universitario de Pontevedra /ID# 207139, Pontevedra

40138

A.O. Policlinico Sant'Orsola Malpighi /ID# 209111, Bologna

40201

Chung Shan Medical University /ID# 208311, Taichung

40447

China Medical University Hosp /ID# 209770, Taichung

41100

AO Univ di Modena /ID# 209110, Modena

44093

CHU de Nantes - Hotel Dieu /ID# 208974, Nantes

44106

Univ Hosp Cleveland /ID# 208852, Cleveland

46015

Hospital Universitario Arnau Vilanova /ID# 207065, Valencia

46026

Hospital Universitario y Politecnico La Fe /ID# 207064, Valencia

46256

Dawes Fretzin, LLC /ID# 209187, Indianapolis

46940

Hospital de Manises /ID# 207062, Manises

48149

Universitatsklinikum Munster /ID# 210935, Munster

48202

Henry Ford Health System /ID# 208741, Detroit

48346

Clarkston Skin Research /ID# 208739, Clarkston

50100

Mikkeli Central Hospital /ID# 210125, Mikkeli

51100

Polyclinique Courlancy /ID# 208975, Reims

56000

UKM Medical Centre /ID# 209178, Kuala Lumpur

59045

CHRU Lille - Hopital Claude Huriez /ID# 209317, Lille

59100

University Malaya Med Ctr /ID# 208861, Kuala Lumpur

60590

Universitaetsklinikum Frankfurt /ID# 210934, Frankfurt

61761

Sneeze, Wheeze, & Itch Associates, LLC /ID# 212058, Normal

62250

Hospital Putrajaya /ID# 209177, Putrajaya

64239

Ichilov Medical Center /ID# 210014, Tel Aviv

64283

Hautklinik Klinikum Darmstadt /ID# 210938, Darmstadt

67200

Keski-pohjanmaa Central Hospital /ID# 209534, Kokkola

68144

Skin Specialists, PC /ID# 208843, Omaha

69063

Military Hospital of Military-Medical Clinical Center of Southern Region /ID# 210435, Zaporizhzhya

72205

University of Arkansas for Medical Sciences /ID# 211688, Little Rock

74132

Southside Dermatology /ID# 212004, Tulsa

76031

Charles Nicolle CHU Rouen /ID# 208973, Rouen

77802

DiscoveResearch, Inc. /ID# 213171, Bryan

78249

Stephen Miller, MD PA /ID# 210071, San Antonio

80802

TU Uniklinik Munchen /ID# 210937, Munich

81100

Hospital Sultan Ismail /ID# 211037, Johor Bahru

84000

Hospital Pakar Sultanah Fatimah /ID# 210185, Muar town

90045

Dermatology Research Associates /ID# 209097, Los Angeles

90056

Los Angelos Cataract Center /ID# 208524, Los Angeles

90220

Oulu University Hospital /ID# 208961, Oulu

92103

Ucsd /Id# 208990, San Diego

95816

UC Davis Health /ID# 209285, Sacramento

97223

Oregon Medical Res Center PC /ID# 208807, Portland

97239

Oregon Health and Science University /ID# 208809, Portland

99202

Premier Clinical Research /ID# 212142, Spokane

119074

National University Hospital /ID# 208774, Singapore

169608

Singapore General Hospital /ID# 208776, Singapore

308205

National Skin Centre /ID# 208775, Singapore

1834111

HaEmek Medical Center /ID# 210153, Afula

4941492

Rabin Medical Center /ID# 210012, Petah Tikva

5239424

Sheba Medical Center /ID# 210013, Ramat Gan

35209-6802

Clinical Research Center AL /ID# 210277, Birmingham

92708-3701

Tien Q Nguyen MD, Inc /ID# 208934, Fountain Valley

93701-2302

UCSF Fresno /ID# 213253, Fresno

90025-4749

Jonathan Corren, MD. INC /ID# 208987, Los Angeles

90025-7014

California Allergy and Asthma Medical Group /ID# 213680, Los Angeles

92660-7853

Dermatology Clinical Trials /ID# 214622, Newport Beach

90404-2102

Clinical Science Institute /ID# 211022, Santa Monica

33016-1897

The Community Research of South Florida /ID# 211145, Hialeah

33173-3570

Miami Dermatology and Laser Institute /ID# 212938, Miami

33406-6063

Integrated Clinical Research LLC /ID# 208831, West Palm Beach

31707-1282

Georgia Pollens Clinical Research Centers, Inc /ID# 211092, Albany

31406-2632

Meridian Clinical Research Dermatology /ID# 213251, Savannah

60611-2927

Northwestern University Feinberg School of Medicine /ID# 208680, Chicago

60654-6903

Medical Dermatology Associates of Chicago /ID# 210265, Chicago

02169

Beacon Clinical Research, LLC /ID# 209280, Quincy

55402-2606

Clinical Research Institute, Inc /ID# 210852, Minneapolis

68505-2343

Allergy, Asthma & Immunology Associates, PC /ID# 213481, Lincoln

03756

Dartmouth-Hitchcock Medical Center /ID# 213727, Lebanon

43210-1257

The Ohio State University /ID# 209254, Columbus

38305-2163

Clinical Research Solutions, LLC /ID# 212542, Jackson

78759-4100

Orion Clinical Research /ID# 208765, Austin

76244-6548

Epiphany Dermatology - Fort Worth /ID# 211187, Fort Worth

78028-9640

Sante Clinical Research /ID# 212970, Kerrville

77479-3153

Sugar Land Allergy, Asthma, and Immunology Center /ID# 211153, Sugar Land

84112-5500

University of Utah /ID# 209001, Salt Lake City

23220-4459

Clinical Research Partners, LLC /ID# 212262, Richmond

T2G 1B1

Kirk Barber Research, CA /ID# 209504, Calgary

T2J 7E1

Dermatology Research Institute Inc. /ID# 210942, Calgary

V3R 6A7

Dr. Chih-ho Hong Medical Inc. /ID# 211032, Surrey

V3V 0C6

Enverus Medical Research /ID# 209503, Surrey

N6H 5L5

Dr. Wei Jing Loo Medicine Prof /ID# 211400, London

L3P 1X2

Lynderm Research Inc. /ID# 209505, Markham

L5H 1G9

DermEdge Research Inc. /ID# 211122, Mississauga

M2M 4J5

Niakosari Medicine Professional Corporation /ID# 211401, Toronto

N2J 1C4

K. Papp Clinical Research /ID# 209509, Waterloo

J7Z 7E2

Dre Angelique Gagne-Henley M.D. inc. /ID# 209498, Saint-Jérôme

625 00

Fakultni Nemocnice Brno /ID# 212968, Brno

500 05

FN Hradec Kralove /ID# 209116, Hradec Králové

586 01

Nemocnice Jihlava, prispevkova organizace /ID# 209131, Jihlava

708 52

Fakultni nemocnice Ostrava /ID# 209117, Ostrava

150 06

Fakultni Nemocnice v Motole /ID# 209209, Prague

06202

Centre Hospitalier Universitaire de Nice - Hopital l'Archet 2 /ID# 213374, Nice

D04 T6F4

St Vincent's University Hosp /ID# 208441, Dublin

X91 ER8E

University Hospital Waterford /ID# 208442, Waterford

00133

Policlinico Univ Tor Vergata /ID# 209112, Rome

4624 VT

Bravis Ziekenhuis /ID# 208584, Bergen op Zoom

1105 AZ

Academisch Medisch Centrum /ID# 208578, Amsterdam

1817 MS

Centrum Oosterwal /ID# 209641, Alkmaar

9713 GZ

Universitair Medisch Centrum Groningen /ID# 208583, Groningen

3015 GD

Erasmus Medisch Centrum /ID# 208582, Rotterdam

3584 CX

Universitair Medisch Centrum Utrecht /ID# 208579, Utrecht

85-094

Szpital Uniwersytecki nr 1 im. dr. A. Jurasza w Bydgoszczy /ID# 211103, Bydgoszcz

30-510

Pratia MCM Krakow /ID# 207444, Krakow

02-758

Klinika Ambroziak Sp. z o.o. /ID# 207443, Warsaw

02-962

Royalderm Agnieszka Nawrocka /ID# 211015, Warsaw

15-879

ClinicMed Daniluk, Nowak Sp.j. /ID# 211112, Bialystok

90-436

Dermoklinika Medical Center /ID# 211026, Lodz

08907

Hospital Universitario de Bellvitge /ID# 207063, L'Hospitalet de Llobregat

214 28

Skanes Universitetssjukhus /ID# 206783, Malmo

SE-17176

Karolinska University Hospital /ID# 207909, Stockholm

04209

Kyiv City Clinical Skin and Venereal Hospital /ID# 210755, Kyiv

BN2 5BE

Royal Alex Childrens County Hospital /ID# 209709, Brighton

KY2 5AH

Victoria Hospital /ID# 209853, Kirkcaldy

G51 4TF

Royal Hospital for Children /ID# 210451, Glasgow

NW3 2QG

The Royal Free Hospital /ID# 208659, London

SE1 9RT

Guy's and St Thomas' NHS Found /ID# 208881, London

CF14 4XN

Cardiff & Vale University Health Board /ID# 209745, Cardiff

Sponsors

Lead Sponsor

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INDUSTRY