Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,407

Participants

Timeline

Start Date

January 4, 2019

Primary Completion Date

March 28, 2025

Study Completion Date

March 30, 2028

Conditions
Advanced Ovarian Cancer
Interventions
DRUG

Bevacizumab

Bevacizumab by intravenous infusion. In tBRCAm cohort bevacizumab is optional according to local practice.

DRUG

Durvalumab

Durvalumab by intravenous infusion

DRUG

Olaparib

Olaparib tablets

DRUG

Placebo olaparib

Placebo tablets to match olaparib

DRUG

Durvalumab placebo

Matching placebo for intravenous infusion

DRUG

Carboplatin+Paclitaxel

Standard of care chemotherapy

Trial Locations (214)

27

Research Site, San Isidro

1062

Research Site, Budapest

1090

Research Site, Vienna

1122

Research Site, Budapest

1260

Research Site, Adana

1307

Research Site, Dresden

1330

Research Site, Sofia

3000

Research Site, Leuven

4000

Research Site, Roskilde

4004

Research Site, Plovdiv

4020

Research Site, Linz

4032

Research Site, Debrecen

5000

Research Site, Namur

Research Site, Odense

6020

Research Site, Innsbruck

6725

Research Site, Szeged

7100

Research Site, Vejle

7400

Research Site, Kaposvár

8000

Research Site, Burgas

8036

Research Site, Graz

8200

Research Site, Aarhus N

8400

Research Site, Ostend

8900

Research Site, Zalaegerszeg

9000

Research Site, Varna

Research Site, Aalborg

9024

Research Site, Győr

9100

Research Site, Sint-Niklaas

9300

Research Site, Aalst

10065

Research Site, New York

10117

Research Site, Berlin

10126

Research Site, Torino

10128

Research Site, Torino

10408

Research Site, Goyang-si

11553

Research Site, Uniondale

12208

Research Site, Albany

13013

Research Site, La Libertad

13273

Research Site, Marseille

13620

Research Site, Seongnam-si

14004

Research Site, Córdoba

14770

Research Site, Brandenburg

15224

Research Site, Pittsburgh

16499

Research Site, Suwon

17475

Research Site, Greifswald

17601

Research Site, Lancaster

18057

Research Site, Rostock

19104

Research Site, Philadelphia

20132

Research Site, Milan

20141

Research Site, Milan

20246

Research Site, Hamburg

20357

Research Site, Hamburg

20521

Research Site, Turku

21204

Research Site, Towson

22457

Research Site, Hamburg

23538

Research Site, Lübeck

23900

Research Site, Lecco

24105

Research Site, Kiel

25000

Research Site, Besançon

25123

Research Site, Brescia

26133

Research Site, Oldenburg

27710

Research Site, Durham

28033

Research Site, Madrid

28034

Research Site, Madrid

28040

Research Site, Madrid

28041

Research Site, Madrid

30035

Research Site, Mirano

30177

Research Site, Hanover

30625

Research Site, Hanover

30912

Research Site, Augusta

33076

Research Site, Bordeaux

33332

Research Site, Gütersloh

33604

Research Site, Bielefeld

33612

Research Site, Tampa

34093

Research Site, Istanbul

34125

Research Site, Kassel

34384

Research Site, Istanbul

35100

Research Site, Izmir

36312

Research Site, Vigo

40489

Research Site, Düsseldorf

42100

Research Site, Reggio Emilia

43026

Research Site, Hilliard

44195

Research Site, Cleveland

44202

Research Site, Nantes

44805

Research Site, Saint-Herblain

45136

Research Site, Essen

45147

Research Site, Essen

45429

Research Site, Dayton

46202

Research Site, Indianapolis

48202

Research Site, Detroit

50935

Research Site, Cologne

53105

Research Site, Bonn

54519

Research Site, Vandœuvre-lès-Nancy

55131

Research Site, Mainz

60521

Research Site, Hinsdale

60590

Research Site, Frankfurt

61352

Research Site, Bad Homburg

63069

Research Site, Offenbach

65807

Research Site, Springfield

67550

Research Site, Worms

68167

Research Site, Mannheim

69373

Research Site, Lyon

70210

Research Site, Kuopio

71640

Research Site, Ludwigsburg

72016

Research Site, Tübingen

73100

Research Site, Lecce

73730

Research Site, Esslingen am Neckar

74134

Research Site, Tulsa

75012

Research Site, Paris

75015

Research Site, Paris

75674

Research Site, Paris

76133

Research Site, Karlsruhe

76135

Research Site, Karlsruhe

79106

Research Site, Freiburg im Breisgau

80131

Research Site, Napoli

81377

Research Site, München

83022

Research Site, Rosenheim

84112

Research Site, Salt Lake City

87042

Research Site, Limoges

89075

Research Site, Ulm

89100

Research Site, Reggio Calabria

90029

Research Site, Oulu

90095

Research Site, Los Angeles

90766

Research Site, Fürth

92610

Research Site, Foothill Ranch

94158

Research Site, San Francisco

97422

Research Site, Schweinfurt

100026

Research Site, Beijing

116001

Research Site, Dalian

130021

Research Site, Changchun

150081

Research Site, Harbin

200011

Research Site, Shanghai

200032

Research Site, Shanghai

226361

Research Site, Nantong

230031

Research Site, Hefei

233060

Research Site, Bengbu

310009

Research Site, Hangzhou

310022

Research Site, Hangzhou

321099

Research Site, Jinhua

400030

Research Site, Chongqing

407280

Research Site, Floreşti

410008

Research Site, Changsha

430030

Research Site, Wuhan

430033

Research Site, Changsha

430060

Research Site, Wuhan

450002

Research Site, Zhengzhou

450008

Research Site, Zhengzhou

510060

Research Site, Guangzhou

510080

Research Site, Guangzhou

519099

Research Site, Zhuhai

530021

Research Site, Nanning

610041

Research Site, Chengdu

637000

Research Site, Nanchong

646099

Research Site, Luzhou

650118

Research Site, Kunming

710061

Research Site, Xi'an

730030

Research Site, Lanzhou

2100008

Research Site, Nanjing

92868-3298

Research Site, Orange

07748

Research Site, Middletown

07645

Research Site, Montvale

19107-5097

Research Site, Philadelphia

14784-400

Research Site, Barretos

88034-000

Research Site, Florianópolis

60810-180

Research Site, Fortaleza

86015-520

Research Site, Londrina

90020-090

Research Site, Porto Alegre

90110-270

Research Site, Porto Alegre

20220-410

Research Site, Rio de Janeiro

01317-000

Research Site, São Paulo

04014-002

Research Site, São Paulo

T2N 5G2

Research Site, Calgary

L4M 6M2

Research Site, Barrie

P3E 5J1

Research Site, Greater Sudbury

M5G 2M9

Research Site, Toronto

H2X 3E4

Research Site, Montreal

H3T 1E2

Research Site, Montreal

H4A 3J1

Research Site, Montreal

G1J 1Z4

Research Site, Québec

G5L 5T1

Research Site, Rimouski

CN-100730

Research Site, Beijing

07747

Research Site, Jena

04103

Research Site, Leipzig

07318

Research Site, Saalfeld

00168

Research Site, Roma

811-1395

Research Site, Fukuoka

277-8567

Research Site, Kashiwa-shi

650-0047

Research Site, Kobe

135-8550

Research Site, Kōtoku

830-0011

Research Site, Kurume-shi

606-8507

Research Site, Kyoto

105-8471

Research Site, Minatoku

464-8681

Research Site, Nagoya

951-8520

Research Site, Niigata

700-8558

Research Site, Okayama

003-0804

Research Site, Sapporo

980-8574

Research Site, Sendai

160-8582

Research Site, Shinjuku-ku

411-8777

Research Site, Sunto-gun

470-1192

Research Site, Toyoake-shi

CALLAO 2

Research Site, Bellavista

LIMA 31

Research Site, Lima

Lima 32

Research Site, Lima

LIMA 34

Research Site, Lima

LIMA 41

Research Site, Lima

81-519

Research Site, Gdynia

93-513

Research Site, Lodz

70-111

Research Site, Szczecin

02-781

Research Site, Warsaw

04-141

Research Site, Warsaw

03080

Research Site, Seoul

03722

Research Site, Seoul

06351

Research Site, Seoul

08221

Research Site, Terrassa(Barcelona)

06230

Research Site, Ankara

06490

Research Site, Ankara

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

collaborator

GOG Foundation, Inc. (GOG Foundation)

UNKNOWN

collaborator

Myriad Genetic Laboratories, Inc.

INDUSTRY

lead

AstraZeneca

INDUSTRY