514
Participants
Start Date
October 15, 2019
Primary Completion Date
December 1, 2023
Study Completion Date
October 31, 2024
Argatroban
Direct Thrombin Inhibitor - Argatroban is a derivative of arginine that competitively binds to the active site of thrombin thereby preventing fibrin deposition. With a half-life of 30 minutes, argatroban has an immediate anticoagulant effect after IV administration which is rapidly reversed with discontinuation of the drug.
Eptifibatide
GP 2b/3a Receptor Inhibitor - The final step of platelet aggregation is mediated via the GP2b/3a receptor. Eptifibatide was specifically developed to ensure rapid inhibition of platelet aggregation (within 15 minutes), a short half-life (\~2 hours) and rapid dissociation from platelets with 50% restoration of platelet function within 2-4 hours of discontinuation.
Placebo
IV placebo solution
Mount Sinai Beth Israel, New York
North Shore University Hospital, Manhasset
SUNY Upstate University Hospital, Syracuse
UPMC Presbyterian Hospital, Pittsburgh
UPMC Mercy Hospital, Pittsburgh
Abington Memorial Hospital, Abington
Hospital of the University of Pennsylvania, Philadelphia
Temple University Hospital, Philadelphia
UVA Medical Center, Charlottesville
Forsyth Medical Center, Winston-Salem
Wake Forest Baptist Medical Center, Winston-Salem
Medical University of South Carolina, Charleston
Prisma Health Greenville Memorial Hospital, Greenville
Grady Memorial Hospital, Atlanta
Baptist Medical Center Jacksonville, Jacksonville
Mayo Clinic Hospital, Jacksonville
Jackson Memorial Hospital, Miami
Tampa General Hospital, Tampa
Sarasota Memorial Hospital, Sarasota
University of Alabama Hospital, Birmingham
Vanderbilt University Hospital, Nashville
University of Kentucky Hospital, Lexington
OSU Wexner Medical Center, Columbus
Cleveland Clinic Akron General, Akron
Mercy Health West Hospital, Cincinnati
University of Cincinnati Medical Center, Cincinnati
The Jewish Hospital, Cincinnati
University of Michigan University Hospital, Ann Arbor
Henry Ford Hospital, Detroit
McLaren Flint, Flint
Trinity Health Saint Mary's, Grand Rapids
Regions Hospital, Saint Paul
Fairview Southdale Hospital, Edina
University of Minnesota Medical Center Hospital, Minneapolis
Loyola University Medical Center, Maywood
Central DuPage Hospital, Winfield
University of Chicago Medical Center, Chicago
Javon Bea Hospital - Riverside, Rockford
St. Louis University Hospital, St Louis
Barnes Jewish Hospital, St Louis
Saint Luke's Hospital, Kansas City
University of Kansas Hospital, Kansas City
St. John Medical Center, Tulsa
Houston Methodist Hospital, Houston
Memorial Hermann-Texas Medical Center, Houston
South Texas Health System McAllen, McAllen
University of Utah Healthcare, Salt Lake City
University of New Mexico Hospital, Albuquerque
Kaiser Permanente Los Angeles Medical Center, Los Angeles
Cedars-Sinai Medical Center, Los Angeles
UCSD Health La Jolla, La Jolla
UCSD Medical Center - Hillcrest Hospital, San Diego
St. Jude Medical Center, Fullerton
UC Irvine Medical Center, Orange
Santa Barbara Cottage Hospital, Santa Barbara
San Francisco General Hospital, San Francisco
UCSF Medical Center, San Francisco
Yale New Haven Hospital, New Haven
Massachusetts General Hospital, Boston
Beth Israel Deaconess Medical Center, Boston
UMASS Memorial Medical Center, Worcester
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Washington University School of Medicine
OTHER