ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

NAActive, not recruitingINTERVENTIONAL
Enrollment

1,948

Participants

Timeline

Start Date

June 10, 2019

Primary Completion Date

June 14, 2024

Study Completion Date

September 30, 2034

Conditions
Aortic Stenosis
Interventions
DEVICE

ACURATE neo2™ Transfemoral TAVR System

ACURATE neo2™ Transfemoral TAVR system: Support frame made of nitinol, supra-annular processed tri-leaflet porcine pericardial valve and an outer skirt to limit paravalvular regurgitation (manufactured by Boston Scientific Corporation, Marlborough, MA, USA).

DEVICE

Medtronic CoreValve TAVR System

Medtronic CoreValve Evolut R or Evolut PRO Transcatheter Aortic Valve Replacement (TAVR) System (or any future Corevalve iterations): The support frame is manufactured from nitinol, which has multilevel, self-expanding properties and is radiopaque. The bioprosthesis is manufactured by suturing valve leaflets and a skirt from porcine pericardium into a tri-leaflet configuration (manufactured by Medtronic CoreValve LLC, Santa Ana, USA).

DEVICE

Edwards SAPIEN 3 TAVR System

Edwards SAPIEN 3 TAVR system (or any future SAPIEN iterations): balloon-expandable transcatheter aortic bioprosthesis, support frame made of cobalt-chromium, three leaflets constructed of processed bovine pericardial tissue and an outer polyethylene terephthalate (PET) sealing cuff to mitigate paravalvular regurgitation (manufactured by Edwards Lifesciences, Inc., Irvine, California, USA)

DEVICE

ACURATE Prime™ Transfemoral TAVR System XL

ACURATE Prime™ Transfemoral TAVR system: Support frame made of nitinol, supra-annular processed tri-leaflet porcine pericardial valve and an outer skirt to limit paravalvular regurgitation (manufactured by Boston Scientific Corporation, Marlborough, MA, USA).

Trial Locations (75)

10029

Mount Sinai Medical Center, New York

10032

Columbia University Medical Center/NYPH, New York

10065

Cornell Presbyterian - New York, New York

10461

Montefiore-Jack D. Weiler Hospital, The Bronx

12208

Albany Medical Center, Albany

14203

Kaleida Health, Buffalo

15213

UPMC Pittsburgh, Pittsburgh

17101

UPMC - Pinnacle, Harrisburg

17403

WellSpan York Hospital, York

19086

Lankenau, Wynnewood

20010

MedStar Washington Hospital Center, Washington D.C.

21218

Union Memorial Hospital, Baltimore

22908

University of Virginia Health System, Charlottesville

23507

Sentara Norfolk General Hospital, Norfolk

27157

Wake Forest University School of Medicine, Winston-Salem

27514

University of North Carolina, Chapel Hill

28203

Carolinas Medical Center, Charlotte

29169

Lexington Medical Center, West Columbia

29425

Medical University of South Carolina, Charleston

30309

Piedmont Hospital, Atlanta

32806

Orlando Regional Medical Center, Orlando

33756

Morton Plant Hospital, Clearwater

35294

University of Alabama at Birmingham, Birmingham

37205

St Thomas Ascension, Nashville

43214

OhioHealth Research and Innovation Institute, Columbus

44106

University Hospitals of Cleveland, Cleveland

44195

Cleveland Clinic, Cleveland

45219

Lindner Center for Research and Education at Christ Hospital, Cincinnati

46290

St. Vincent's Hospital, Indianapolis

48109

University of Michigan, Ann Arbor

48202

Henry Ford Hospital, Detroit

52242

University of Iowa, Iowa City

53024

Aurora Research Institute, Milwaukee

53226

Medical College of Wisconsin - Froedtert Hospital, Milwaukee

54301

Bellin Health, Green Bay

55102

St. Joseph's Hospital-St. Paul, Saint Paul

55407

Abbott Northwestern Hospital, Minneapolis

56303

CentraCare Heart and Vascular Center, Saint Cloud

60201

NorthShore University Health Study Coordinator, Evanston

60453

Advocate Christ Medical Center, Oak Lawn

62769

St. John's Hospital (Prairie), Springfield

72205

Baptist Health Medical Center, Little Rock

73112

Integris Baptist Medical Center, Oklahoma City

75093

Baylor Regional Medical Center at Plano, Plano

75226

Baylor Heart and Vascular Hospital, Dallas

75231

Presbyterian Hospital of Dallas, Dallas

77030

The Methodist Hospital Research Institute, Houston

The University of Texas Health Science Center at Houston, Houston

78229

Methodist Healthcare System of San Antonio dba Methodist Hospital, San Antonio

78705

Austin Heart, Austin

85006

Banner Good Samaritan, Phoenix

85260

HonorHealth Scottsdale Healthcare, Scottsdale

85712

TMC HealthCare, Tucson

90027

Kaiser Permanente Los Angeles, Los Angeles

90048

Cedars-Sinai Heart Institute, Los Angeles

92037

Scripps Clinic, La Jolla

94115

Kaiser Permanente - San Francisco, San Francisco

94305

Stanford University Medical Center, Stanford

95817

University of California, Davis Medical Center, Sacramento

97225

Providence Heart Institute, Portland

97477

Sacred Heart Medical Center - Riverbend, Springfield

98201

Providence Regional Medical Center, Everett

02114

Massachusetts General Hospital, Boston

02115

Brigham and Women's Hospital, Boston

01655

University of Massachusetts, Worcester

08015

Deborah Heart and Lung Center, Browns Mills

07631

Englewood Health, Englewood

08901

Robert Wood Johnson Medical Center, New Brunswick

05401

The University of Vermont Medical Center, Burlington

V3L 3W5

Royal Columbian Hospital, New Westminster

V6Z 1Y6

Providence Health - St. Paul's Hospital, Vancouver

N6A 5A5

London Health Sciences, London

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

H2X 3E4

Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal

G1V 4G5

Institut Universitaire de Cardiologie et de Pneumologie de Quebec (IUCPQ), Québec

Sponsors
All Listed Sponsors
lead

Boston Scientific Corporation

INDUSTRY