Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery

CompletedOBSERVATIONAL
Enrollment

40

Participants

Timeline

Start Date

July 1, 2016

Primary Completion Date

July 1, 2021

Study Completion Date

July 1, 2021

Conditions
Esophageal CancerNutrition DisordersAppetite DisordersDumping SyndromeDelayed Gastric EmptyingSurgery
Interventions
DRUG

Octreotide Acetate

50mcg octreotide acetate by subcutaneous injection 10 minutes prior to a 400kcal mixed meal challenge

DRUG

Saline Solution

Equivalent volume of 0.9% saline by subcutaneous injection 10 minutes prior to a 400kcal mixed meal challenge

DRUG

Paracetamol

Paracetamol 1g by mouth consumed with a 400kcal mixed meal challenge

DRUG

Sulfasalazine

1g sulfasalazine by mouth consumed with a 400kcal mixed meal challenge

DIAGNOSTIC_TEST

Duodenal biopsy

Biopsy from the second part of the duodenum taken at routine endoscopic surveillance, undertaken for another clinical indication.

Trial Locations (2)

D4

Department of Surgery, St. James's Hospital, Dublin

D8

Wellcome Trust-Health Research Board Clinical Research Facility, St. James's Hospital, Dublin

All Listed Sponsors
lead

St. James's Hospital, Ireland

OTHER

NCT03734627 - Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery | Biotech Hunter | Biotech Hunter