557
Participants
Start Date
December 27, 2018
Primary Completion Date
January 11, 2022
Study Completion Date
August 1, 2026
Trastuzumab deruxtecan (DS-8201a)
DS-8201a is a lyophilized powder reconstituted into a sterile aqueous solution (100 mg/5 mL) to be administered intravenously
Capecitabine
Administered according to label, as one option for Physician's Choice (determined before randomization)
Eribulin
Administered according to label, as one option for Physician's Choice (determined before randomization)
Gemcitabine
Administered according to label, as one option for Physician's Choice (determined before randomization)
Paclitaxel
Administered according to label, as one option for Physician's Choice (determined before randomization)
Nab-paclitaxel
Administered according to label, as one option for Physician's Choice (determined before randomization)
National Taiwan University Hospital, Taipei
National Cheng Kung University Hospital, Tainan City
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City
Institut Jules Bordet, Brussels
Centre Hospitalier Universitaire Vaudois, Lausanne
AKH - Medizinische Universität Wien (4305), Vienna
Universitair Ziekenhuis Brussel, Brussels
Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet, Budapest
Orszagos Onkologiai Intezet, Budapest
Cliniques Universitaires Saint-Luc, Brussels
UZ Leuven, Leuven
Kepler Universitätsklinikum, Linz
Universitaetsspital Basel, Basel
Debreceni Egyetem, Debrecen
SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz, Nyíregyháza
Klinikum Wels-Grieskirchen GmbH, Wels
CHU UCL Namur, Namur
Hirslanden Medical Center, Aarau
Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet, Szolnok
LKH - Universitätsklinikum der PMU Salzburg, Salzburg
Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza, Gyula
Medizinische Universität Innsbruck, Innsbruck
Grand Hôpital de Charleroi, Loverval
Kantonsspital Graubuenden, Chur
Centre Hospitalier Wallonie picarde - Site IMC, Tournai
Universitaetsspital Zuerich, Zurich
Kantonsspital Winterthur, Winterthur
Kantonsspital St. Gallen, Sankt Gallen
New York University Medical Center, New York
Memorial Sloan Kettering Hospital, New York
Weill Cornell Medicine Breast Center, New York
National Cancer Center, Goyang-si
"General Hospital of Athens Alexandra", Athens
Institut Paoli Calmettes, Marseille
Ziv Medical Center, Safed
Seoul National University Bundang Hospital, Seongnam-si
Centre François Baclesse, Caen
"General Oncology Hospital of Kifissia Agioi Anargyroi", Athens
Complejo Hospitalario Universitario A Coruña, A Coruña
Athens Medical Center, Athens
Allegheny General Hospital, Pittsburgh
University of Pittsburgh Medical Center Health System, Pittsburgh
Ajou University Hospital, Suwon
Karolinska universitetssjukhuset - Solna, Solna
Christiana Care Health Services, Inc., Newark
Hospital Universitario Donostia, San Sebastián
Fudan University Shanghai Cancer Center, Shanghai
Istituto Clinico Humanitas, Rozzano
IEO Istituto Europeo di Oncologia, Milan
Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo), Monza
Virginia Cancer Specialists, Fairfax
CARIO - Centre Armoricain de Radiothérapie, Imagerie médicale et Oncologie, Plérin
Inha University Hospital, Incheon
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili), Brescia
MD Anderson Cancer Centre, Madrid
Hospital Ruber Internacional, Madrid
Hospital Universitario Ramon y Cajal, Madrid
Hospital Universitario Clinico San Carlos, Madrid
Hospital Clinico Universitario Virgen de la Victoria, Málaga
St Francis Hospital, Greenville
CHU Brest - Hôpital Morvan, Brest
Cancer Treatment Centers of America-Georgia, Newnan
Orlando Health, Inc., Orlando
Memorial Healthcare System MRH Cancer Center, Hollywood
Institut Bergonié, Bordeaux
Moffitt Cancer Center -Tampa, Tampa
Sylvester Comprehensive Cancer Center - Deerfield Beach, Boca Raton
Florida Cancer Specialists (South Region), Fort Myers
Clinique Clementville, Montpellier
Institut Régional du Cancer de Montpellier, Montpellier
CRLCC Eugene Marquis, Rennes
Ospedale Sacro Cuore Don Calabria, Negrar
Tennessee Oncology - Skyline Satellite, Nashville
Brig Center for Cancer Care and Survivorship, Knoxville
Baptist Cancer Center, Memphis
Hospital Universitario de Canarias, San Cristóbal de La Laguna
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi, Bologna
Hospital Universitario Virgen Macarena, Seville
Hospital Universitario Virgen del Rocio, Seville
University General Hospital of Larissa, Larissa
Kyungpook National University Chilgok Hospital, Daegu
Centre Hospitalier Emile Roux, Le Puy-en-Velay
The Cleveland Clinic Foundation, Cleveland
ICO - Site René Gauducheau, Saint-Herblain
Instituto Valenciano de Oncologia IVO, Valencia
Hospital General Universitario de Valencia, Valencia
Ospedale degli Infermi, Rimini
Hospital de Basurto, Bilbao
Henry Ford Hospital, Detroit
ICO - Site Paul Papin, Angers
Rabin Medical Center-Beilinson Campus, Petah Tikva
Chaim Sheba Medical Center, Ramat Gan
Bioclinic Thessaloniki, Thessaloniki
Euromedica General Clinic Thessaloniki, Thessaloniki
General Hospital Papageorgiou, Thessaloniki
Interbalkan Hospital of Thessaloniki, Thessaloniki
Centre Hospitalier Valenciennes, Valenciennes
Cancer Treatment Centers of America, Zion
University of Chicago Medical Center, Chicago
Saint Luke's Hospital of Kansas City, Kansas City
Cancer Center of Kansas, Wichita
Universitaetsklinikum Heidelberg, Heidelberg
Touro Infirmary, New Orleans
University General Hospital of Heraklion, Heraklion
Clinique Victor Hugo - Centre Jean Bernard, Le Mans
Azienda Ospedaliera Card. G. Panico, Tricase
Institut Curie - site de Paris, Paris
Hopital Tenon, Paris
Akademiska Sjukhuset, Uppsala
BloomTrials Clinical Research, LLC, Dallas
Hôpital Saint-Louis - Paris, Paris
The Methodist Hospital Research Institute, Houston
University of Texas M. D. Anderson Cancer Center - Investigational Cancer Therapeutics, Houston
Istituto Nazionale Tumori Fondazione G. Pascale, Napoli
Klinikum der Universitaet Muenchen - Campus Grosshardern, Munich
Institut Sainte Catherine, Avignon
Länssjukhuset Sundsvall-Härnösand, Sundsvall
Ironwood Cancer & Research Centers - Chandler II, Chandler
Banner MD Anderson Cancer Center, Gilbert
Cancer Treatment Centers of America at Western Regional Medical Center, Goodyear
Azienda Ospedaliero Universitaria Mater Domini-Campus Universitario, Catanzaro
UCLA School of Medicine, Los Angeles
Cancer Care Associates Medical Group, Inc. TORI, Redondo Beach
University of California at San Francisco (PARENT), San Francisco
Hôpital d'Instruction des Armees Begin*, Saint-Mandé
Stanford Cancer Institute, Palo Alto
Institut Gustave Roussy, Villejuif
Azienda Ospedaliera Univ. Policlinico Gaspare Rodolico, Catania
Oregon Health & Science University, Portland
Cancer Hospital Chinese Academy of Medical Sciences, Beijing
Chinese PLA General Hospital, Beijing
Liaoning Cancer Hospital & Institute, Shenyang
"FSBSI Russian Oncological Scientific Center n.a. N.N. Blokhin", Moscow
The First Hospital of Jilin University, Changchun
Jilin Cancer Hospital, Changchun
"SBIH of Moscow City Moscow City Oncology Hospital №62 of Moscow Healthcare Departement", Moscow
"SBIH of Yaroslavl Region Regional Clinical Oncological Hospital", Yaroslavl
Harbin Medical University Cancer Hospital, Harbin
Shanghai General Hospital, Shanghai
The Affiliated Drum Tower Hospital of Nanjing University, Nanjing
Anhui Provincial Hospital, Hefei
Linyi Cancer Hospital, Linyi
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Fuzhou
Hubei Cancer Hospital, Wuhan
Sun Yat-sen Memorial hospital, Sun Yat-sen University, Guangzhou
West China Hospital, Sichuan University, Chengdu
General Hospital of Ningxia Medical University, Yinchuan
Rambam Health Care Center, Haifa
Tel Aviv Sourasky Medical Center, Tel Aviv
Kaplan Medical Center, Rehovot
Shaare Zedek Medical Center, Jerusalem
Hadassah University Hospital - Ein Kerem, Jerusalem
Eastern Connecticut Hematology/Oncology Assoc., Norwich
Dana-Farber Cancer Institute, Boston
Saint Barnabas Medical Center, Livingston
Tom Baker Cancer Center, Calgary
Toronto Sunnybrook Hospital, Toronto
McGill University - Dept. Oncology Clinical Research Program, Montreal
Azienda Ospedaliera Universitaria Policlinico Tor Vergata, Roma
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma
Aichi Cancer Center Hospital, Nagoya
National Cancer Center Hospital East, Kashiwa-shi
NHO Shikoku Cancer Center, Matsuyama
NHO Kyushu Cancer Center, Fukuoka
Fukushima Medical University Hospital, Fukushima
Hiroshima City Hiroshima Citizens Hospital, Hiroshima
NHO Hokkaido Cancer Center, Sapporo
Hyogo College of Medicine Hospital, Nishinomiya-shi
Hakuaikai Sagara Hospital, Kagoshima
Tokai University Hospital, Isehara
Kanagawa Cancer Center, Yokohama
NHO Osaka National Hospital, Osaka
Kindai University Hospital, Onohigashi
Saitama Cancer Center, Kitaadachi-gun
Shizuoka Cancer Center, Sunto-gun
Cancer Institute Hospital of JFCR, Kōtoku
Toranomon Hospital, Minatoku
Showa University Hospital, Shinagawa-Ku
Hospital de Braga, Braga
Centro Hospitalar do Alto do Ave, EPE, Guimarães
Fundação Champalimaud, Lisbon
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisbon
Unidade Local de Saúde de Matosinhos, EPE (Hospital Pedro Hispano), Matosinhos Municipality
Centro Hospitalar do Porto, E.P.E. - Hospital de Santo António, Porto
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto
Centro Hospitalar de Entre o Douro e Vouga, E.P.E - Hospital de São Sebastião, Santa Maria da Feira
Centro Hospitalar Vila Nova de Gaia/Espinho, E.P.E, Vila Nova de Gaia
Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE, Vila Real
Chungbuk National University Hospital, Cheongju-si
Seoul National University Hospital, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
ICO l'Hospitalet - Hospital Duran i Reynals, L'Hospitalet de Llobregat
Hospital del Mar, Barcelona
Hospital Quironsalud Barcelona, Barcelona
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clinic de Barcelona, Barcelona
Royal Cornwall Hospital, Truro
Queen Mary University of London, London
University College London Hospitals, London
Royal Free Hospital, London
Western General Hospital, Edinburgh
Nottingham University Hospitals City Campus, Nottingham
Royal Surrey County Hospital, Guildford
Lead Sponsor
Collaborators (2)
Daiichi Sankyo Co., Ltd.
INDUSTRY
AstraZeneca
INDUSTRY
Daiichi Sankyo
INDUSTRY