A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia

PHASE3CompletedINTERVENTIONAL
Enrollment

652

Participants

Timeline

Start Date

November 1, 2018

Primary Completion Date

August 8, 2022

Study Completion Date

February 28, 2024

Conditions
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Interventions
DRUG

Zanubrutinib

160 mg orally twice daily

DRUG

Ibrutinib

Ibrutinib 420 mg orally once daily

Trial Locations (115)

2025

Middlemore Clinical Trials, Auckland

2298

Calvary Mater Newcastle, Waratah

2610

Gasthuiszusters Antwerpen Sint Augustinus, Wilrijk

3112

Tauranga Hospital, Tauranga

3128

Box Hill Hospital, Box Hill

3168

Monash Health, Clayton

3199

Peninsula Private Hospital, Frankston

3204

Waikato Hospital, Hamilton

4101

Icon Cancer Foundation, South Brisbane

4102

Princess Alexandra Hospital, Brisbane

6000

Royal Perth Hospital, Perth

6021

Wellington Regional Hospital (Ccdhb), Wellington

8011

Christchurch Hospital (Canterbury Health Laboratories), Christchurch

10032

Columbia University Medical Center, New York

10126

Azienda Ospedaliera Citta Della Salute E Della Scienza Di Torino, Torino

11590

Clinical Research Alliance, Inc, Westbury

15748

Interhem Opieka Szpitalna, Bialystok

17007

Ico Girona, Girona

20132

Ospedale San Raffaele, Milan

20162

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan

24014

Blue Ridge Cancer Care (Oncology and Hematology Associates of Southwest Virginia), Roanoke

27705

Duke University Hospital, Durham

28034

Hospital Universitario Ramon Y Cajal, Madrid

28046

Hospital Universitario La Paz, Madrid

28222

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda

30912

Augusta University, Augusta

33705

Scri Florida Cancer Specialists North, St. Petersburg

33901

Scri Florida Cancer Specialists South, Fort Myers

35510

Hopital Prive Sevigne, Cesson-Sévigné

37000

Chu Tours Hopital Bretonneau Service Pneumologie, Tours

37203

Sarah Cannon Cancer Center, Nashville

37404

Scri Tennessee Oncology Chattanooga, Chattanooga

39008

Hospital Universitario Marques de Valdecilla, Santander

39401

Forrest General Hospital Cancer Center, Hattiesburg

40207

Norton Cancer Institute Pavilion, Louisville

45004

Hospital Virgen de La Salud, Toledo

50005

Fakultni Nemocnice Hradec Kralove, Hradec Králové

50937

Uniklinik Koln (Aor), Cologne

59063

Evangelisches Krankenhaus Hamm, Hamm

59100

Namik Kemal University, Tekirdağ

62500

Fakultni Nemocnice Brno, Brno

64132

Scri Hca Midwest Health, Kansas City

68198

Nebraska Medical Center, Omaha

69495

Chu Hopital Lyon Sud, PierreBenite

72037

Centre Hospitalier Le Mans, Le Mans

72205

Carti Cancer Center, Little Rock

75702

Texas Oncology Tyler Longview, Tyler

77900

Fakultni Nemocnice Olomouc, Olomouc

78240

Texas Oncology San Antonio Medical Center Usor, San Antonio

79410

Joe Arrington Cancer Research and Treatment Center, Lubbock

80303

Rocky Mountain Cancer Centers Boulder, Boulder

85925

Centre Hospitalier Departemental de Vendee, La Roche-sur-Yon

86000

Centre Hospitalier Universitaire de Poitier Hopital de La Miletrie Hopital Jean Bernard, Poitiers

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

90095

David Geffen School of Medicine At UCLA, Los Angeles

97239

Oregon Health and Science University, Portland

97477

Willamette Valley Cancer Center, Springfield

98108

Va Puget Sound Health Care System, Seattle

98109

Fred Hutchinson Cancer Research Center, Seattle

99208

Medical Oncology Associates, Spokane

100000

Peking University Third Hospital, Beijing

100050

Beijing Friendship Hospital, Capital Medical University, Beijing

100730

Peking Union Medical College Hospital, Beijing

110004

Shengjing Hospital of China Medical University, Shenyang

130021

The First Hospital of Jilin University, Changchun

200032

Affiliated Zhongshan Hospital of Fudan University, Shanghai

200092

Tongji Hospital of Tongji University, Shanghai

210029

Jiangsu Province Hospital, Nanjing

300020

Institute of Hematology and Hospital of Blood Disease, Tianjin

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310003

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

325000

The First Provincial Wenzhou Hospital of Zhejiang, Wenzhou

350001

Fujian Medical University Union Hospital, Fuzhou

362000

Quanzhou First Affliated Hospital of Fujian Medical University, Quanzhou

430022

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan

450000

Henan Cancer Hospital, Zhengzhou

510080

Guangdong Provincial Peoples Hospital, Guangzhou

510515

Nanfang Hospital of Southern Medical University, Guangzhou

610041

West China Hospital, Sichuan University, Chengdu

02215

Dana Farber Cancer Institute, Boston

07960

Atlantic Health System, Morristown

Morristown Medical Center, Morristown

76104-2150

Texas Oncology Fort Worth Cancer Center, Fort Worth

77030-4009

The University of Texas Md Anderson Cancer Center, Houston

708 00

Fakultni Nemocnice Ostrava, Ostrava

00168

Fondazione Policlinico Universitario Agostino Gemelli, Roma

7334 DZ

Gelre Ziekenhuizen, Apeldoorn

6525 GA

Albert Schweitzer Ziekenhuis, Nijmegen

0622

North Shore Hospital, Takapuna

36-200

Szpital Specjalist W Brzozowie,Podkarpacki Osrodek Onkologiczny, Brzozów

41-500

Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich, Chorzów

80-219

Copernicus Podmiot Leczniczy Sp Z Oo Wojewodzkie Centrum Onkologii, Gdansk

80-952

Uniwersyteckie Centrum Kliniczne, Gdansk

30-510

Malopolskie Centrum Medyczne Sc, Krakow

59-220

Wojewodzki Szpital Specjalistyczny W Legnicy, Legnica

93-510

Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz

60-569

Examen Sp Z Oo, Poznan

08916

Hospital Universitari Germans Trias I Pujol, Badalona

08025

Hospital de La Santa Creu I Sant Pau, Barcelona

08035

Hospital Universitario Vall Dhebron, Barcelona

08036

Hospital Clinic I Provincial, Barcelona

221 85

Skanes Universitetssjukhus I Lund, Lund

171 76

Karolinska Universitetssjukhuset Solna, Stockholm

AB25 2ZN

Nhs Grampian Ppds, Aberdeen

B9 5SS

Birmingham Heartlands Hospital, Birmingham

BH7 7DW

The Royal Bournemouth and Christchurch Hospitals Nhs Foundation, Bournemouth

CT1 3NG

Kent and Canterbury Hospital, Canterbury

LS9 7LP

St Jamess Institute of Oncology, Leeds

EC1A 7BE

Barts Health Nhs Trust, London

NR4 7UY

Norfolk and Norwich University Hospitals Nhs Foundation Trust, Norwich

NG51PB

Nottingham University Hospitals Nhs Trust, Nottingham

PL6 8DH

Derriford Hospital, Plymouth

SO16 6YD

Southampton General Hospital, Southampton

SR4 7TP

Sunderland Royal Hospital, Sunderland

PO7 7XX

Genesiscare Oxford, Waterlooville

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY

NCT03734016 - A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia | Biotech Hunter | Biotech Hunter