Panitumumab-IRDye800 and 89Zr-Panitumumab in Identifying Metastatic Lymph Nodes in Patients With Squamous Cell Head and Neck Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

14

Participants

Timeline

Start Date

January 7, 2019

Primary Completion Date

December 11, 2020

Study Completion Date

August 9, 2021

Conditions
Squamous Cell Carcinoma of the Head and NeckCarcinoma of the Head and Neck
Interventions
DRUG

Panitumumab-IRDye800

30 mg administered intravenously (IV)

DRUG

89-Zirconium (Zr-89) Panitumumab

0.8 to 1.2 mCi (29 to 45 Mbq) administered intravenously (IV)

DEVICE

Pinpoint IR IR9000 fluorescence imaging system (FIS)

Handheld fluorescence-imaging endoscope manufactured by Novadaq

DEVICE

SPY-PHI IR9000 fluorescence imaging system (FIS)

Handheld fluorescence-imaging endoscope manufactured by Novadaq

DEVICE

Explorer Air camera

Fluorescence camera manufactured by SurgVision

DEVICE

PDE-NEO II camera

Medical infrared camera manufactured by Hamamatsu Photonics KK

DEVICE

FIS-00 fluorescence imaging system (FIS)

Fluorescence-imaging system (FIS) manufactured by Hamamatsu Photonics KK

DEVICE

Da Vinci Firefly Imaging System

Fluorescence-imaging endoscope, mounted or stand-alone, manufactured by Intuitive Surgical Inc

DEVICE

IGP-ELVIS-v4 Macroscopic Specimen Imager

Macroscopic specimen imager manufactured by LI-COR Biosciences

DEVICE

Vevo 3100 LAZR-X

Photoacoustic ultrasound imaging system manufactured by VisualSonics

DEVICE

Pearl Triology Imaging System

Near-infrared fluorescent and bioluminescent imaging system manufactured by LI-COR Biosciences

DEVICE

Odyssey CLx Imaging System

Infrared fluorescent-imaging system manufactured by LI-COR Biosciences

DEVICE

Leica fluorescence microscope

Fluorescence microscope manufactured by Leica

Trial Locations (1)

94304

Stanford Cancer Institute Palo Alto, Palo Alto

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

collaborator

National Cancer Institute (NCI)

NIH

lead

Andrei Iagaru

OTHER

NCT03733210 - Panitumumab-IRDye800 and 89Zr-Panitumumab in Identifying Metastatic Lymph Nodes in Patients With Squamous Cell Head and Neck Cancer | Biotech Hunter | Biotech Hunter