454
Participants
Start Date
January 11, 2019
Primary Completion Date
February 5, 2021
Study Completion Date
August 24, 2023
Atezolizumab
Atezolizumab will be administered as per the schedule specified in the respective arm.
Placebo
Placebo matched to atezolizumab will be administered as per the schedule specified in the respective arm.
Doxorubicin
Doxorubicin will be administered as per the schedule specified in the respective arm.
Cyclophosphamide
Cyclophosphamide will be administered as per the schedule specified in the respective arm.
Paclitaxel
Paclitaxel will be administered as per the schedule specified in the respective arm.
Trastuzumab
Trastuzumab will be administered as per the schedule specified in the respective arm.
Pertuzumab
Pertuzumab will be administered as per the schedule specified in the respective arm.
Trastuzumab Emtansine
Participants without pCR have the option of receiving adjuvant atezolizumab/placebo combined with Trastuzumab Emtansine 3.6 mg/kg IV Q3W.
Mackay Memorial Hospital; Dept of Surgery, Taipei
Chang Gung Medical Foundation - Linkou; Dept of Surgery, Taoyuan District
China Medical University Hospital; Surgery, Taichung
New York University Medical Center PRIME; NYU Langone Medical Center, New York
Fondazione Del Piemonte Per L'oncologia Ircc Di Candiolo; Dipartimento Oncologico, Candiolo
Koo Foundation Sun Yat-Sen Cancer Center; Hemato-Oncology, Taipei
Hospital Clinico de Granada; Servicio de Oncologia, Granada
Istituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia, Rozzano
Kooperatives Mammazentrum Hamburg Krankenhaus Jerusalem, Hamburg
ASST DI MONZA; Oncologia Medica, Monza
Gachon University Gil Medical Center, Incheon
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia, Jaén
ASST DEGLI SPEDALI CIVILI DI BRESCIA; Oncologia Medica, Brescia
Hospital Universitari Arnau de Vilanova de Lleida; Servicio de Oncologia, Lleida
Clinica Universidad de Navarra Madrid; Servicio de Oncología, Madrid
Centro Integral Oncologico Clara Campal; Servicio de Oncología, Madrid
Hospital Universitario Virgen de La Arrixaca; Servicio De Oncologia, El Palmar
Clinica Universitaria de Navarra; Servicio de Oncologia, Pamplona
Irccs Centro Di Riferimento Oncologico (CRO); Dipartimento Di Oncologia Medica, Aviano
St. Vincenz-Krankenhaus Paderborn; Haus 3 Frauenklinik, Paderborn
IOV - Istituto Oncologico Veneto - IRCCS; Oncologia Medica II, Padua
Tennessee Oncology - Nashville, Nashville
Hospital Universitario Virgen Macarena; Servicio de Oncologia, Seville
Hospital Universitario Virgen del Rocio; Servicio de Oncologia, Seville
Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH; Klinik für Senologie / Brustzentrum, Essen
Universitätsklinikum Münster; Klinik für Frauenheilkunde und Geburtshilfe, Münster
HCA Midwest Division, Kansas City
Praxis für Interdisziplinäre Onkologie und Hämatologie GbR, Freiburg im Breisgau
Istituto Nazionale Tumori Irccs Fondazione g. PASCALE;U.O.C. Oncologia Medica Senologica, Napoli
Università degli Studi Federico II; Clinica di Oncologia Medica, Napoli
Rotkreuzklinikum München; Frauenklinik, München
Universitätsfrauenklinik Ulm; Abteilung Gynäkologie, Ulm
"SBIH Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM", Moskva
Blokhin Cancer Research Center; Combined Treatment, Moskva
City Clinical Oncology Hospital, Moscow
Petrov Research Inst. of Oncology, Saint Petersburg
FSBI National Medical Research Radiological Center; A. TSYB MEDICAL RADIOLOGICAL RESEARCH CENTER, Obninsk
Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic, Kazan'
Hospital Sao Rafael - HSR, Salvador
Hospital Araujo Jorge; Departamento de Ginecologia E Mama, Goiânia
Hospital Nossa Senhora da Conceicao, Porto Alegre
Hospital Sao Lucas - PUCRS, Porto Alegre
Hospital Perola Byington, São Paulo
Tom Baker Cancer Centre-Calgary, Calgary
BCCA-Vancouver Cancer Centre, Vancouver
Jewish General Hospital, Montreal
Hopital du Saint Sacrement, Québec
Masarykuv onkologicky ustav, Brno
Fakultni nemocnice Olomouc; Onkologicka klinika, Olomouc
Sankt Elisabeth Krankenhaus; Gynaekology, Leipzig
Policlinico Universitario Agostino Gemelli, Rome
National Hospital Organization Shikoku Cancer Center, Ehime
Hiroshima City Hiroshima Citizens Hospital, Hiroshima
Hiroshima University Hospital, Hiroshima
National Hospital Organization Hokkaido Cancer Center, Hokkaido
Hyogo Cancer Center, Hyōgo
Kanagawa Cancer Center, Kanagawa
Tokai University Hospital, Kanagawa
Kumamoto Shinto General Hospital, Kumamoto
Fukushima Medical University Hospital, Miyagi
Niigata Cancer Center Hospital, Niigata
Saitama Medical University International Medical Center, Saitama
Toranomon Hospital, Tokyo
Showa University Hospital, Tokyo
"Instytut Centrum Zdrowia Matki Polki; Klinika Onkologii", ?ód?
Narodowy Inst.Onkol.im.Sklodowskiej-Curie Panstw.Inst.Bad Gliwice; Centr.Diagn.i Lecz.Chor.Piersi, Gliwice
Regionalny Szpital Specjalistyczny im. W. Bieganskiego; Oddzial Onkologii Klinicznej, Grudzi?dz
Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii, Krakow
Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad; Klinika Nowtw.Piersi i Chir.Rekonstr, Warsaw
Korea University Anam Hospital, Seoul
Seoul National University Hospital, Seoul
Samsung Medical Centre; Oncology, Seoul
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia, Badalona
Hospital Univ Vall d'Hebron; Servicio de Oncologia, Sant Andreu de la Barca
Hospital Clínic i Provincial; Servicio de Hematología y Oncología, Barcelona
Complejo Asistencial Universitario De Burgos; Servicio de Oncologia, Burgos
Collaborators (1)
Chugai Pharmaceutical
INDUSTRY
Hoffmann-La Roche
INDUSTRY