Safety and Efficacy of Tipifarnib in Head and Neck Cancer With HRAS Mutations and Impact of HRAS on Response to Therapy

PHASE2CompletedINTERVENTIONAL
Enrollment

296

Participants

Timeline

Start Date

March 15, 2019

Primary Completion Date

May 2, 2023

Study Completion Date

May 2, 2023

Conditions
HRAS Gene MutationHNSCC
Interventions
DRUG

Tipifarnib

Tablet for oral administration

DEVICE

HRAS Detection Assay

In Vitro Assay to detect HRAS mutations

Trial Locations (102)

100

National Taiwan University Hospital, Taipei

407

Taichung Veterans General Hospital, Taichung

500

Changhua Christian Hospital, Changhua

1090

Allgemeines Krankenhaus der Stadt Wien, Vienna

1140

Hanusch Krankenhaus Wiener Gebietskrankenkasse, Vienna

1200

Cliniques Universitaires Saint-Luc, Brussels

1521

Haukeland Universitetssjukehus, Bergen

2020

Ziekenhuis Netwerk Antwerpen Middelheim, Antwerp

2065

Royal North Shore Hospital, Saint Leonards

2100

Rigshospitalet, Copenhagen

2650

Universitair Ziekenhuis Antwerpen, Edegem

2730

Herlev Hospital, Herlev

3000

Peter MacCallum Cancer Centre, Melbourne

Universitair Ziekenhuis Leuven, Leuven

5530

Centre Hospitalier Universitaire Universite Catholique de Louvain Site Godinne, Yvoir

10016

New York University Langone Medical Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10099

Mackay Memorial Hospital, Taipei

10330

King Chulalongkorn Memorial Hospital, Bangkok

10408

National Cancer Center, Goyang-si

12100

Azienda Ospedaliera S. Croce e Carle Cuneo, Cuneo

12203

Charité Universitätsmedizin Berlin, Berlin

12462

University General Hospital of Athens Attikon, Chaïdári

15707

Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela

16247

The Catholic University of Korea St. Vincent's Hospital, Suwon

19111

Fox Chase Cancer Center, Philadelphia

20133

Fondazione IRCCS - Istituto Nazionale dei Tumori - Milano, Milan

20442

Chang Gung Medical Foundation Keelung Chang Gung Memorial Hospital, Keelung

21204

Greater Baltimore Medical Center, Baltimore

21287

Marlene and Stewart Greenebaum Cancer Center, Baltimore

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28050

HM Centro Integral Oncológico Clara Campal, Madrid

28204

Levine Cancer Institute, Charlotte

29010

Hospital Universitario Virgen de la Victoria, Málaga

29603

Hospital Costa Del Sol, Marbella

30322

Winship Cancer Institute, Atlanta

31008

Complejo Hospitalario de Navarra, Pamplona

33176

Miami Cancer Institute, Miami

33305

Chang Gung Memorial Hospital, Taoyuan District

33612

University of South Florida H. Lee Moffitt Cancer Center and Research Institute, Tampa

37045

Ospedale Mater Salutis di Legnago, Legnago

37232

Vanderbilt University Medical Center-Vanderbilt Ingram Cancer Center, Nashville

40138

Azienda Ospedaliero Universitaria di Bologna Policlinico Sant'Orsola-Malpighi, Bologna

40202

Norton Cancer Institute, Louisville

40447

China Medical University Hospital, Taichung

40536

University of Kentucky Markey Cancer Center, Lexington

41013

Hospital Universitario Virgen del Rocio, Seville

41110

University General Hospital of Larissa, Larissa

43210

The Ohio State University, Columbus

46026

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

47014

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

48201

Barbara Ann Karmanos Cancer Institute, Detroit

50009

Hospital Universitario Miguel Servet, Zaragoza

50200

Maharaj Nakorn Chiang Mai Hospital, Chiang Mai

53100

Azienda Ospedaliera Universitaria Senese-L'ospedale Santa Maria alle Scotte, Siena

53705

University of Wisconsin, Madison

54622

Bioclinic - Thessaloniki, Thessaloniki

54907

Chonbuk National University Hospital, Jeonju

55905

Mayo Clinic, Rochester

59100

University Malaya Medical Centre, Kuala Lumpur

60637

University of Chicago, Chicago

62250

Institut Kanser Negara, Putrajaya

63129

Siteman Cancer Center - Washington University Medical Campus, St Louis

66205

University Of Kansas Medical Center, Westwood

68167

Universitätsmedizin Mannheim, Mannheim

70403

National Cheng Kung University Hospital, Tainan City

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

The University of Texas MD Anderson Cancer Center, Houston

78229

University of Texas Health San Antonio - Mays Cancer Center, San Antonio

78234

San Antonio Military Medical Center, Fort Sam Houston

80131

Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli

83301

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

90033

University of Southern California Norris Comprehensive Cancer Center, Los Angeles

90095

UCLA - Jonsson Comprehensive Cancer Center, Los Angeles

90110

Songklanagarind Hospital, Hat Yai

90603

The Oncology Institute of Hope and Innovation - Anaheim, Whittier

94158

UCSF - Helen Diller Family Comprehensive Cancer Center, San Francisco

97080

Universitätsklinikum Würzburg, Würzburg

98109

Seattle Cancer Care Alliance, Seattle

02115

Dana Farber Cancer Institute, Boston

04103

Universitätsklinikum Leipzig, Leipzig

9713 GZ

Universitair Medisch Centrum Groningen, Groningen

6229 HX

Maastricht University Medical Centre, Maastricht

3584 CX

Universitair Medisch Centrum Utrecht, Utrecht

0379

Radiumhospitalet, Oslo

02841

Korea University Anam Hospital, Seoul

03722

Yonsei University Health System Severance Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea - Seoul St. Mary's Hospital, Seoul

08003

Hospital del Mar - Parc de Salut Mar, Barcelona

08025

Hospital de la Santa Creu i de Sant Pau, Barcelona

08035

Hospital Universitari Vall d'Hebrón, Barcelona

08036

Hospital Clinic i Provincial de Barcelona, Barcelona

08908

Hospital Duran i Reynals, Barcelona

SE1 9RT

Guy's and Saint Thomas' NHS Foundation Trust, London

G12 0XH

NHS Greater Glasgow and Clyde, Glasgow

NW1 2BU

University College London Hospitals NHS Foundation Trust, London

SW3 6JJ

The Royal Marsden NHS Foundation Trust, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

SM2 5PT

The Royal Marsden NHS Foundation Trust, Sutton

Sponsors
All Listed Sponsors
lead

Kura Oncology, Inc.

INDUSTRY

NCT03719690 - Safety and Efficacy of Tipifarnib in Head and Neck Cancer With HRAS Mutations and Impact of HRAS on Response to Therapy | Biotech Hunter | Biotech Hunter