Investigational Therapeutics for the Treatment of People With Ebola Virus Disease

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

681

Participants

Timeline

Start Date

November 21, 2018

Primary Completion Date

September 9, 2019

Study Completion Date

August 18, 2020

Conditions
Ebola Virus
Interventions
DRUG

ZMapp

Three doses of 50 mg/kg of body weight administered intravenously every third day beginning on Day 1

DRUG

Remdesivir

Administered intravenously with a loading dose on Day 1 (200 mg for adults and pediatric patients with body weight \>= 40 kg and for pediatric patients weighing \< 40 kg one loading dose of remdesivir 5 mg/kg) followed by 9 to 13 days of once-daily maintenance dosing starting on Day 2 and extending through Day 10 to 14 (100 mg for adults and pediatric patients with body weight \>= 40 kg and for pediatric patients weighing \< 40 kg remdesivir 2.5 mg/kg)

DRUG

MAb114

50 mg/kg of body weight administered intravenously on Day 1 as a single infusion

DRUG

REGN-EB3

150 mg/kg of body weight administered intravenously on Day 1 as a single infusion

Trial Locations (2)

20892

National Institutes of Health Clinical Center, Bethesda

Unknown

Ebola Treatment Centers throughout the DRC, Kinshasa Gombe

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT03719586 - Investigational Therapeutics for the Treatment of People With Ebola Virus Disease | Biotech Hunter | Biotech Hunter