681
Participants
Start Date
November 21, 2018
Primary Completion Date
September 9, 2019
Study Completion Date
August 18, 2020
ZMapp
Three doses of 50 mg/kg of body weight administered intravenously every third day beginning on Day 1
Remdesivir
Administered intravenously with a loading dose on Day 1 (200 mg for adults and pediatric patients with body weight \>= 40 kg and for pediatric patients weighing \< 40 kg one loading dose of remdesivir 5 mg/kg) followed by 9 to 13 days of once-daily maintenance dosing starting on Day 2 and extending through Day 10 to 14 (100 mg for adults and pediatric patients with body weight \>= 40 kg and for pediatric patients weighing \< 40 kg remdesivir 2.5 mg/kg)
MAb114
50 mg/kg of body weight administered intravenously on Day 1 as a single infusion
REGN-EB3
150 mg/kg of body weight administered intravenously on Day 1 as a single infusion
National Institutes of Health Clinical Center, Bethesda
Ebola Treatment Centers throughout the DRC, Kinshasa Gombe
National Institute of Allergy and Infectious Diseases (NIAID)
NIH