NCT03719183View on ClinicalTrials.gov

Comparison of Diagnostic Yield Among M-FISH, FISH Probe Panel and Conventional Cytogenetic Analysis in AML

CompletedOBSERVATIONAL
Enrollment

120

Participants

Timeline

Start Date

January 1, 2019

Primary Completion Date

December 31, 2021

Study Completion Date

December 31, 2021

Conditions
Acute Myeloid Leukemia
Interventions
DIAGNOSTIC_TEST

Conventional Cytogenetics Studies

Metaphase cytogenetic studies will be performed in all cases according to standard methods. Chromosome preparations will be G-banded using trypsin and Giemsa, and karyotypes will be described according to the International System for Human Cytogenetic Nomenclature (ISCN) 2016.

DIAGNOSTIC_TEST

Fluorescent in Situ Hybridization (FISH) Panels

"AML Panel includes:~* t(8;21) (RUNX1-RUNX1T1).~* inv(16), t(16;16) (CBFB-MYH11).~* t(9;22) (BCR-ABL).~* 11q23 KMT2A rearrangements.~* inv(3) MECOM rearrangements.~* DEK-NUP214 rearrangements.~* Del(5q) Deletion~* Del(7q) Deletion~Acute Promyelocytic Leukemia panel includes:~* t(15;17) (PML-RARA).~* 17q RARA rearrangements"

DIAGNOSTIC_TEST

Multiplex FISH (M-FISH)

24-color karyotyping

Trial Locations (1)

71515

South Egypt Cancer Institute, Asyut

All Listed Sponsors
collaborator

South Egypt Cancer Institute

OTHER

lead

Assiut University

OTHER

NCT03719183 - Comparison of Diagnostic Yield Among M-FISH, FISH Probe Panel and Conventional Cytogenetic Analysis in AML | Biotech Hunter | Biotech Hunter