40
Participants
Start Date
October 23, 2018
Primary Completion Date
June 15, 2022
Study Completion Date
June 15, 2022
Phenylephrine
blood pressure will be increased or decreased by using one of six interventions: phenylephrine (alpha-1 agonist), dexmedetomidine (alpha-2 agonist), clevidipine (Ca channel blocker, CaCl, tetanic stimulus and increase in venous pressure
Dexmedetomidine
blood pressure will be increased or decreased by using one of six interventions: phenylephrine (alpha-1 agonist), dexmedetomidine (alpha-2 agonist), clevidipine (Ca
Clevidipine
blood pressure will be increased or decreased by using one of six interventions: phenylephrine (alpha-1 agonist), dexmedetomidine (alpha-2 agonist), clevidipine (Ca
tetanic stimulus
A 5 second 70 mA tetanic stimulus will be applied to elicit peripheral vasoconstriction (stress response)
Increased venous pressure
A 5 minute inflation of a noninvasive blood pressure cuff to 30 mmHg to increase venous pressure in the arm with the pulse oximeter probes.
Calcium Chloride
CaCl will be administered to increase blood pressure and plasma calcium concentration
University of California San Francisco, San Francisco
University of California, San Francisco
OTHER