26
Participants
Start Date
January 3, 2019
Primary Completion Date
September 1, 2019
Study Completion Date
December 12, 2019
Botulinum toxin type A
"Botulinum toxin type A will be injected in all patients at both sides into the Yonsei point, (3Units) the point that would target 3 muscles responsible for upper lip elevation during smiling, including the LLSAN, in a single injection. This landmark was identified as the center of a triangle formed by the convergence of the LLSAN, the LLS, and the Zminor muscles and is located 1 cm lateral to the ala horizontally and 3 cm above the lip line vertically in both men and women (Hwang et al. 2009) and (Nasr et al. 2015)."
Zinc supplementation
zinc supplementation will be given to patients in the intervention arm 4 days prior to Botulinum toxin type A injection
Faculty of Dentistry, Cairo University, Cairo
Cairo University
OTHER