128
Participants
Start Date
October 4, 2018
Primary Completion Date
December 31, 2025
Study Completion Date
January 31, 2026
Continuous thoracic epidural analgesia
"Needle/catheter: 17 Ga. × 80 mm Tuohy epidural needle (Perican®, B. Braun Medical Inc., Bethlehem, PA, USA); Arrow FlexTip Plus® 19 Ga. epidural catheter (Arrow International Inc., Reading, PA, USA)~Level of insertion and patient positioning: T6-T8, upright sitting position for insertion of needle and catheter (to 5 cm beyond loss-of-resistance point) and for injection of test dose (3 mL 2% lidocaine with epinephrine 1:200,000); supine for injection of bolus dose~Confirmation of correct placement: Loss of resistance to air or saline; negative aspiration of the epidural catheter; negative test dose; and ease of injection of an initial bolus dose"
Spinal anesthesia with intrathecal morphine
"Needle/catheter: 25 Ga. × 90 mm high-flow Whitacre spinal needle (Becton-Dickinson, Franklin Lakes, NJ, USA)~Level of insertion and patient positioning: L2-L3, lateral decubitus position during injection; immediately post-injection, patient is placed supine in \<5% degree of Trendelenburg~Confirmation of correct placement: Aspiration of cerebrospinal fluid"
Bupivacaine 0.75% in Dextrose Inj 8.25%
0.25 mg⋅kg-¹ hyperbaric bupivacaine 0.75%
Morphine
3 mcg⋅kg-¹ intrathecal morphine (preservative-free)
Bupivacaine 0.25% Preservative-Free Injectable Solution
0.25 mg⋅kg-¹ bupivacaine 0.25%
Bupicavaine 0.125% epidural solution
Epidural solution, bupivacaine 0.125% with hydromorphone 10 mcg·mL-¹, infusion range 0.075-0.125 mL⋅kg-¹⋅h-¹
Hydromorphone 10 mcg/mL epidural solution
Epidural solution, bupivacaine 0.125% with hydromorphone 10 mcg·mL-¹, infusion range 0.075-0.125 mL⋅kg-¹⋅h-¹
RECRUITING
University of Manitoba, Winnipeg
University of Manitoba
OTHER