Spinal Anesthesia For Enhanced Recovery After Liver Surgery

NARecruitingINTERVENTIONAL
Enrollment

128

Participants

Timeline

Start Date

October 4, 2018

Primary Completion Date

December 31, 2025

Study Completion Date

January 31, 2026

Conditions
HepatectomyPain, PostoperativeLiver Neoplasms
Interventions
PROCEDURE

Continuous thoracic epidural analgesia

"Needle/catheter: 17 Ga. × 80 mm Tuohy epidural needle (Perican®, B. Braun Medical Inc., Bethlehem, PA, USA); Arrow FlexTip Plus® 19 Ga. epidural catheter (Arrow International Inc., Reading, PA, USA)~Level of insertion and patient positioning: T6-T8, upright sitting position for insertion of needle and catheter (to 5 cm beyond loss-of-resistance point) and for injection of test dose (3 mL 2% lidocaine with epinephrine 1:200,000); supine for injection of bolus dose~Confirmation of correct placement: Loss of resistance to air or saline; negative aspiration of the epidural catheter; negative test dose; and ease of injection of an initial bolus dose"

PROCEDURE

Spinal anesthesia with intrathecal morphine

"Needle/catheter: 25 Ga. × 90 mm high-flow Whitacre spinal needle (Becton-Dickinson, Franklin Lakes, NJ, USA)~Level of insertion and patient positioning: L2-L3, lateral decubitus position during injection; immediately post-injection, patient is placed supine in \<5% degree of Trendelenburg~Confirmation of correct placement: Aspiration of cerebrospinal fluid"

DRUG

Bupivacaine 0.75% in Dextrose Inj 8.25%

0.25 mg⋅kg-¹ hyperbaric bupivacaine 0.75%

DRUG

Morphine

3 mcg⋅kg-¹ intrathecal morphine (preservative-free)

DRUG

Bupivacaine 0.25% Preservative-Free Injectable Solution

0.25 mg⋅kg-¹ bupivacaine 0.25%

DRUG

Bupicavaine 0.125% epidural solution

Epidural solution, bupivacaine 0.125% with hydromorphone 10 mcg·mL-¹, infusion range 0.075-0.125 mL⋅kg-¹⋅h-¹

DRUG

Hydromorphone 10 mcg/mL epidural solution

Epidural solution, bupivacaine 0.125% with hydromorphone 10 mcg·mL-¹, infusion range 0.075-0.125 mL⋅kg-¹⋅h-¹

Trial Locations (1)

R3E 0Z2

RECRUITING

University of Manitoba, Winnipeg

All Listed Sponsors
lead

University of Manitoba

OTHER