794
Participants
Start Date
December 31, 2018
Primary Completion Date
June 21, 2022
Study Completion Date
September 24, 2024
lenvatinib
Administered orally once a day
pembrolizumab
Administered as an IV infusion on Day 1 Q3W
saline placebo
Administered as an IV infusion on Day 1 Q3W
National Taiwan University Hospital ( Site 0523), Taipei
Taipei Veterans General Hospital ( Site 0524), Taipei
Chang Gung Medical Foundation. Linkou ( Site 0525), Taoyuan District
China Medical University Hospital ( Site 0527), Taichung
Taichung Veterans General Hospital ( Site 0526), Taichung
Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 0529), Kaoshiung
Auckland City Hospital ( Site 0376), Auckland
Royal Prince Alfred Hospital ( Site 0001), Camperdown
Liverpool Hospital. ( Site 0002), Liverpool
St Vincents Hospital Melbourne ( Site 0003), Fitzroy
Monash Health-Monash Medical Centre ( Site 0004), Clayton
Princess Alexandra Hospital ( Site 0007), Wooloongabba
Christchurch Hospital ( Site 0377), Christchurch
Icahn School of Medicine at Mount Sinai ( Site 0611), New York
Siriraj Hospital. Mahidol Univerisity ( Site 0213), Bangkok Noi
Stony Brook University Medical Center - Cancer Center ( Site 0612), Stony Brook
Hopital Saint Joseph ( Site 0166), Marseille
Seoul National University Bundang Hospital ( Site 0464), Seongnam-si
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 0363), Mexico City
University of Rochester ( Site 0613), Rochester
Complejo Hospitalario Universitario de Santiago ( Site 0506), Santiago de Compostela
Eastern Regional Medical Center, Inc. ( Site 0626), Philadelphia
Georgetown University ( Site 0594), Washington D.C.
Centro de Investigacion Medica Aguascalientes ( Site 0355), Aguascalientes
Universitaetsklinikum Hamburg-Eppendorf ( Site 0184), Hamburg
Trakya Universitesi Tip Fakultesi ( Site 0544), Edirne
Erzurum Ataturk University Faculty of Medicine ( Site 0546), Erzurum
Fondazione Salvatore Maugeri IRCCS. ( Site 0290), Pavia
Hospital General Universitario Gregorio Maranon ( Site 0504), Madrid
Hospital Universitario Ramon y Cajal ( Site 0514), Madrid
Hospital Universitario La Paz ( Site 0510), Madrid
Hospital Universitario Puerta de Hierro ( Site 0513), Majadahonda
Emory University Winship Cancer Institute ( Site 0639), Atlanta
Advent Health ( Site 0595), Orlando
Centro di Riferimento Oncologico de Aviano Istituto Nazionale Tumori ( Site 0292), Aviano
University of Miami, Sylvester Comprehensive Cancer Center ( Site 0596), Miami
Tampa General Medical Group ( Site 0629), Tampa
Bezmi Alem Universitesi Tıp Fakultesi ( Site 0547), Istanbul
Centre Eugene Marquis ( Site 0158), Rennes
Istituto Oncologico Veneto ( Site 0287), Padua
Ospedale Sacro Cuore - Don Calabria ( Site 0289), Negrar
Otto-Von-Guericke-Universitaet Magdeburg ( Site 0182), Magdeburg
Policlinico S. Orsola-Malpighi ( Site 0286), Bologna
Hospital Universitario Virgen del Rocio ( Site 0509), Seville
Necmettin Erbakan Universitesi Meram Tip Fakultesi ( Site 0550), Konya
Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0365), Guadalajara
Inonu Universitesi Medical Fakultesi ( Site 0545), Malatya
Centre Hospitalier Regional du Orleans ( Site 0169), Orléans
Universitaetsklinikum Essen ( Site 0188), Essen
Hospital Universitario y Politecnico La Fe de Valencia ( Site 0505), Valencia
Chiang Mai University Maharaj Nakorn Chiang Mai Hospital ( Site 0211), Chiang Mai
Universitaetsklinik Koeln ( Site 0189), Cologne
Klinikum der Universitaet Aachen - RWTH ( Site 0185), Aachen
CHU de Nancy Hopital Brabois Adultes ( Site 0164), Vandœuvre-lès-Nancy
Azienda Ospedaliero-Univers. Pisana Ospedale S. Chiara ( Site 0291), Pisa
CHRU de Lille - Hopital Claude Huriez ( Site 0159), Lille
Universitaetsklinikum Frankfurt ( Site 0180), Frankfurt am Main
University of Kansas Cancer Center ( Site 0600), Westwood
Oaxaca Site Management Organization S.C. ( Site 0366), Oaxaca City
Hopital de la Croix Rousse ( Site 0157), Lyon
National Cheng Kung University Hospital ( Site 0528), Tainan City
Universitaetsklinikum Tuebingen ( Site 0179), Tübingen
Unidad Medica Oncologica ( Site 0369), Puebla City
University of Oklahoma Health Science Center ( Site 0625), Oklahoma City
Central Texas Veterans Healthcare System ( Site 0617), Temple
Institut Sainte Catherine ( Site 0167), Avignon
The University of Arizona Cancer Center - North Campus ( Site 0621), Tucson
Songklanagarind Hospital ( Site 0214), Hat Yai
Az Osp Univ Policlin Paolo Giaccone ( Site 0284), Palermo
UCLA ( Site 0589), Santa Monica
City of Hope Comprehensive Cancer Center ( Site 0587), Duarte
Scripps Health ( Site 0644), La Jolla
Hopital Beaujon ( Site 0160), Clichy
CHU Henri Mondor ( Site 0162), Créteil
Pacific Hematology Oncology Associates ( Site 0588), San Francisco
Medical Care and Research S.A. de C.V. ( Site 0359), Mérida
Universitaetsklinikum Wuerzburg ( Site 0186), Würzburg
Oregon Health & Science University ( Site 0645), Portland
Cancer Care Northwest ( Site 0636), Spokane
Cancer Hospital Chinese Academy of Medical Sciences ( Site 0100), Beijing
Beijing Cancer Hospital ( Site 0088), Beijing
Administradora Country SA - Clinica del Country ( Site 0146), Bogotá
Instituto Nacional de Cancerologia E.S.E ( Site 0142), Bogotá
N.N. Blokhin NMRCO ( Site 0439), Moscow
First Moscow State Medical University n.a. I.M.Sechenov ( Site 0453), Moscow
Railway Hospital of OJSC ( Site 0447), Saint Petersburg
City Clinical Oncology Center ( Site 0446), Saint Petersburg
Fudan University Shanghai Cancer Center ( Site 0086), Shanghai
Zhongshan Hospital Fudan University ( Site 0096), Shanghai
The 81st Hospital of PLA ( Site 0085), Nanjing
First Affiliated Hospital of Anhui Medical University ( Site 0095), Hefei
The First Affiliated Hospital of Zhejiang University ( Site 0097), Hangzhou
Sir Run Run Shaw Hospital ( Site 0110), Hangzhou
Zhejiang Cancer Hospital ( Site 0101), Hangzhou
900 Hospital of the Joint ( Site 0091), Fuzhou
Pyatigorsk Oncology Dispensary ( Site 0441), Pyatigorsk
Hunan Cancer Hospital ( Site 0094), Changsha
The Third Xiangya Hospital of Central South University ( Site 0093), Changsha
Wuhan Union hospital Cancer Center ( Site 0105), Wuhan
Hospital General de Medellin Luz Castro de Gutierrez ( Site 0137), Medellín
Guangdong General Hospital ( Site 0092), Guangzhou
Southern Medical University Nanfang Hospital ( Site 0102), Guangzhou
Harbin Medical University Cancer Hospital ( Site 0089), Harbin
West China Hospital of Sichuan University ( Site 0087), Chengdu
Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0450), Krasnoyarsk
The First Affiliated Hospital of Xi an Jiaotong University ( Site 0090), Xi’an
Fundacion Valle del Lili ( Site 0140), Santiago de Cali
Centro Medico Imbanaco de Cali S.A ( Site 0139), Santiago de Cali
Affiliated Tumor Hospital of Xinjiang Medical University ( Site 0109), Ürümqi
Clinica Universidad Catolica del Maule ( Site 0065), Talca
Instituto Clinico Oncologico del Sur ( Site 0067), Temuco
Fundacion Arturo Lopez Perez ( Site 0064), Santiago
Pontificia Universidad Catolica de Chile ( Site 0070), Santiago
Massachusetts General Hospital ( Site 0603), Boston
Beth Israel Deaconess Medical Center ( Site 0716), Boston
BC Cancer-Vancouver Center ( Site 0056), Vancouver
London Health Sciences Centre ( Site 0053), London
Sunnybrook Research Institute ( Site 0055), Toronto
Princess Margaret Cancer Centre ( Site 0050), Toronto
McGill University Health Centre ( Site 0052), Montreal
Fundacion Centro de Investigacion Clinica CIC ( Site 0141), Medellín
Hospital Pablo Tobon Uribe ( Site 0144), Medellín
Biomelab S A S ( Site 0145), Barranquilla
Universitaetsklinikum Carl Gustav Carus der TU Dresden ( Site 0178), Dresden
Universitaetsklinikum Leipzig ( Site 0187), Leipzig
St Vincents University Hospital ( Site 0242), Dublin
Mater Misericordiae University Hospital ( Site 0241), Dublin
Policlinico Universitario Campus Biomedico ( Site 0288), Roma
Aichi Cancer Center Hospital ( Site 0316), Nagoya
National Cancer Center Hospital East ( Site 0306), Kashiwa
Kurume University Hospital ( Site 0322), Kurume
Hokkaido P.W.F.A.C Sapporo-Kosei General Hospital ( Site 0304), Sapporo
Kanazawa University Hospital ( Site 0315), Kanazawa
Kagawa University Hospital ( Site 0324), Kita-gun
Kagawa Prefectural Central Hospital ( Site 0325), Takamatsu
Toranomon Hospital Kajigaya ( Site 0312), Kawasaki
Yokohama City University Medical Center ( Site 0313), Yokohama
Kanagawa Cancer Center ( Site 0314), Yokohama
Kindai University Hospital ( Site 0319), Sayama
Kyorin University Hospital ( Site 0309), Mitaka
Musashino Red Cross Hospital ( Site 0310), Musashino
Chiba University Hospital ( Site 0305), Chiba
National Hospital Organization Kyushu Medical Center ( Site 0321), Fukuoka
Hiroshima University Hospital ( Site 0320), Hiroshima
Osaka Red Cross Hospital ( Site 0317), Osaka
Saga-Ken Medical Centre Koseikan ( Site 0323), Saga
National Cancer Center Hospital ( Site 0307), Tokyo
Toranomon Hospital ( Site 0311), Tokyo
The University of Tokyo Hospital ( Site 0308), Tokyo
Wakayama Medical University Hospital ( Site 0318), Wakayama
CRYPTEX Investigacion Clinica S.A. de C.V. ( Site 0362), Mexico City
Hacettepe Uni. Tip Fakultesi ( Site 0553), Ankara
Wojewodzki Szpital Specjalistyczny nr 4 w Bytomiu ( Site 0419), Bytom
Szpital Wojewodzki w Koszalinie im. Mikolaja Kopernika ( Site 0421), Koszalin
ID Clinic ( Site 0431), Mysłowice
Ars Medical Sp. z o.o. ( Site 0433), Piła
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0418), Warsaw
MTZ Clinical Research Sp. z o. o. ( Site 0427), Warsaw
Seoul National University Hospital ( Site 0462), Seoul
Yonsei University Severance Hospital ( Site 0463), Seoul
Asan Medical Center ( Site 0460), Seoul
Samsung Medical Center ( Site 0461), Seoul
Hospital Universitari Vall d Hebron ( Site 0508), Barcelona
Adana Sehir Hastanesi ( Site 0549), Adana
Abdurrahman Yurtaslan Onkoloji Hastanesi ( Site 0551), Ankara
Akdeniz Universitesi Tip Fakultesi ( Site 0548), Antalya
Royal Free London NHS Foundation Trust ( Site 0567), London
Kings College Hospital NHS Foundation Trust ( Site 0565), London
The Clatterbridge Cancer Centre NHS Foundation Trust ( Site 0573), Birkenhead
The Beatson West of Scotland Cancer Centre ( Site 0566), Glasgow
The Christie NHS Foundation Trust ( Site 0575), Manchester
Nottingham University Hospitals NHS Trust ( Site 0569), Nottingham
Eisai Inc.
INDUSTRY
Merck Sharp & Dohme LLC
INDUSTRY