128
Participants
Start Date
May 24, 2019
Primary Completion Date
August 26, 2024
Study Completion Date
October 18, 2025
Palbociclib
Phase 1: Administered (oral) at 55 mg/m2, 75 mg/m2, or 40 mg/m2, or 95 mg/m2 or 115 mg/m2 on days 1-14 of a 21-day cycle Phase 1 Tumor specific cohort-Neuroblastoma and Phase 2 : Administered (oral) at 75 mg/m2 on days 1-14 of a 21-day cycle
Temozolomide
Phase 1 and Phase 2: Administered at 100 mg/m2 (oral or intravenous), on days 1-5 of a 21-day cycle
Irinotecan
Phase 1 and Phase 2: Administered at 50 mg/m2 (intravenous), on days 1-5 of a 21-day cycle
Topotecan
Phase 1 only : Administered at 0.75 mg/m2 (intravenous), on days 1-5 of a 21-day cycle
Cyclophosphamide
Phase 1 only: Administered at 250 mg/m2 (intravenous), on days 1-5 of a 21-day cycle
Morgan Stanley Children's Hospital of New York-Presbyetrian Hospital, New York
National Cancer Center, Goyang-si
Montefiore Medical Center, The Bronx
Cohen Children's Medical Center, New Hyde Park
Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone, Marseille
John R. Oishei Childrens Hospital, Buffalo
Roswell Park Cancer Institute, Buffalo
UPMC Children's Hospital of Pittsburgh, Pittsburgh
Penn State Children's Hospital and Penn State Health Milton S. Hershey Medical Center, Hershey
Buerger Center for Advanced Pediatric Care, Philadelphia
Children's Hospital of Philadelphia, Philadelphia
Children's National Hospital, Washington D.C.
Johns Hopkins University, Baltimore
Children's Hospital of Richmond at VCU, Richmond
Children's Hospital of The King's Daughters, Norfolk
Hospital Infantil Universitario Niño Jesús, Madrid
Children's Healthcare of Atlanta at Egleston, Atlanta
Children's Healthcare of Atlanta at Scottish Rite, Atlanta
Children's Healthcare of Atlanta, Medical Office Building, Atlanta
UF Health Shands Hospital, Gainesville
University of Florida College of Medicine, Gainesville
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux
Johns Hopkins All Children's Hospital, Tampa
Johns Hopkins All Children's Hospital, St. Petersburg
Johns Hopkins All Children's Outpatient Care Center, St. Petersburg
Ege Universitesi Hastanesi, Izmir
University of Alabama at Birmingham/Children's of Alabama, Birmingham
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
Novak Center for Children's Health, Louisville
Nationwide Children's Hospital, Columbus
University Hospitals Cleveland Medical Center, Cleveland
Cincinnati Children's Liberty Campus, Liberty Township
Universitätsklinikum Essen, Essen
Cincinnati Children's Hospital Medical Center, Cincinnati
Indiana University, Indianapolis
University of Michigan Health System, Ann Arbor
Children's Wisconsin, Milwaukee
Medical College of Wisconsin, Milwaukee
University of Minnesota Masonic Children's Hospital, Minneapolis
University of Minnesota Medical Center, Fairview, Minneapolis
University of Minnesota/Masonic Cancer Center, Minneapolis
University of Minnesota, Minneapolis
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
Washington University School of Medicine, St Louis
Children's Mercy Hospital, Kansas City
Centre Leon Berard, Lyon
University of Oklahoma Health Sciences Center, Oklahoma City
Children's Medical Center Plano, Plano
Children's Medical Center Dallas, Dallas
Cook Children's H/O Infusion Center, Grapevine
Cook Children's Medical Center, Fort Worth
Texas Children's Hospital, Houston
Children's Blood and Cancer Center, Austin
Dell Children's Medical Center, Austin
Children's Hospital Colorado, Aurora
Narodny ustav detskych chorob, Bratislava
Intermountain - Primary Children's Hospital, Salt Lake City
Primary Children's Hospital Outpatient Services, Salt Lake City
Phoenix Children's Hospital, Phoenix
Children's Hospital Los Angeles, Los Angeles
MemorialCare Health System - Long Beach Medical Center, Long Beach
Children's Hospital of Orange County, Orange
UCSF Medical Center, San Francisco
University of California San Francisco,, San Francisco
Lucile Packard Children's Hospital, Palo Alto
Children's Hospital and Research Center at Oakland, Oakland
Gustave Roussy, Villejuif
Oregon Health & Science University, Portland
Seattle Children's Hospital, Seattle
All India Institute of Medical Sciences, New Delhi
Rajiv Gandhi Cancer Institute And Research Centre, New Delhi
Artemis hospital, Gurugram
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos
Hospital de Clinicas de Porto Alegre, Porto Alegre
Robert Wood Johnson University Hospital, New Brunswick
Rutgers Cancer Institute of New Jersey, New Brunswick
Hospital Pequeno Principe / A ssociacao Hospitalar de Protecao a Infancia, Curitiba
Hospital Pequeno Príncipe, Curitiba
Hospital de Clinicas de Porto Alegre, Porto Alegre
Instituto Nacional de Câncer - INCA, Rio de Janeiro
Hospital Santa Marcelina, São Paulo
Alberta Children's Hospital, Calgary
Stollery Children's Hospital, Edmonton
The Hospital for Sick Children, Toronto
CHU Sainte-Justine, Montreal
Detska nemocnice FN Brno, Brno
Fakultni nemocnice v Motole, Prague
Centre Leon Berard, Lyon
Instytut Matki i Dziecka, Warsaw
Detska fakultna nemocnica s poliklinikou Banska Bystrica, Banská Bystrica
Seoul National University Hospital, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Hospital Universitari Vall d'Hebron, Barcelona
Sahlgrenska Universitetssjukhuset Östra, Gothenburg
Hacettepe Universite Hastaneleri, Ankara
Royal Victoria Infirmary, Newcastle upon Tyne
Royal Hospital for Children, Glasgow
Leeds General Infirmary, Leeds
University College London Hospital, NHS Foundation Trust, London
Lead Sponsor
Children's Oncology Group
NETWORK
Pfizer
INDUSTRY