IMMUNOtherapy and Stereotactic ABlative Radiotherapy (IMMUNOSABR) a Phase II Study

PHASE2TerminatedINTERVENTIONAL
Enrollment

88

Participants

Timeline

Start Date

April 4, 2019

Primary Completion Date

January 6, 2025

Study Completion Date

January 6, 2025

Conditions
NSCLC Stage IVMetastatic Disease
Interventions
DRUG

Darleukin

The product name refers to the molecule structure, in fact, L19-IL2 is a recombinant fusion protein composed of two moieties: L19, a human monoclonal antibody fragment in the single chain Fv (scFv) format, bound via a flexible linker to IL2, the human cytokine Interleukin-2.

RADIATION

Radiation

Radiotherapy

Trial Locations (15)

Unknown

UCL St. Luc, Brussels

UZ Gent, Ghent

UZ Leuven, Leuven

GZA Ziekenhuizen campus Sint-Augustinus, Wilrijk

Centre Oscar Lambret Lille, Lille

INSTITUT régional du CANCER MONTPELLIER - ICM - VAL d'AURELLE, Montpellier

University Hospital Carl Gustav Carus, Dresden

Klinikum der Universität Heidelberg, Heidelberg

University Hospital Tübingen, Tübingen

Fondazione Policlinico Universitario Agostino Gemelli IRCCS Università Cattolica del Sacro Cuore, Rome

AVL-NKI, Amsterdam

Radboud UMC Nijmegen, Nijmegen

Erasmus MC, Rotterdam

University College London Hospital, London

6229HX

Academisch Ziekenhuis Maastricht (Leading Centre), Maastricht

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Academisch Ziekenhuis Maastricht

OTHER

collaborator

The Netherlands Cancer Institute

OTHER

collaborator

University Medical Center Nijmegen

OTHER

collaborator

Erasmus Medical Center

OTHER

collaborator

University Ghent

OTHER

collaborator

KU Leuven

OTHER

collaborator

Centre Oscar Lambret

OTHER

collaborator

Gasthuis Zusters Antwerpen

OTHER

collaborator

University College, London

OTHER

collaborator

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

OTHER

collaborator

University Hospital Dresden

OTHER

collaborator

University Hospital Tuebingen

OTHER

collaborator

Heidelberg University

OTHER

collaborator

Catholic University of the Sacred Heart

OTHER

collaborator

Institut du Cancer de Montpellier - Val d'Aurelle

OTHER

lead

Maastricht University Medical Center

OTHER

NCT03705403 - IMMUNOtherapy and Stereotactic ABlative Radiotherapy (IMMUNOSABR) a Phase II Study | Biotech Hunter | Biotech Hunter