442
Participants
Start Date
June 28, 2016
Primary Completion Date
May 31, 2026
Study Completion Date
May 31, 2026
Synovial Alpha-defensin assay
One of the synovial fluid (joint fluid) tests that will be performed by the outside lab, CD Diagnostics.
Synovial Neutrophil elastase assay
One of the synovial fluid (joint fluid) tests that will be performed by the outside lab, CD Diagnostics.
Synovial lactate assay
Synovial Fluid (joint fluid) will be sent out to CD Diagnostics for this test.
Synovial C-reactive Protein (CRP)
One of the synovial fluid (joint fluid) tests that will be performed by the outside lab, CD Diagnostics.
Synovial Staphylococcus spp antigen panel
One of the synovial fluid (joint fluid) tests that will be performed by the outside lab, CD Diagnostics.
Synovial Candida spp antigen panel
One of the synovial fluid (joint fluid) tests that will be performed by the outside lab, CD Diagnostics.
Synovial Enterococcus faecalis assay
One of the synovial fluid (joint fluid) tests that will be performed by the outside lab, CD Diagnostics.
Synovial bacterial culture by BacT/Alert
The synovial fluid (joint fluid) sent to CD Diagnostics for testing will also be cultured to see if any organisms grow.
Synovial Cell count + differential (CBC)
One of the synovial fluid (joint fluid) tests that will be performed by the outside lab, CD Diagnostics.
Synovial Gram Stain
This will be performed by CD Diagnostics if any organisms are present in the synovial fluid.
Synovial Leukocyte Esterase Test Strips
These test strips will be tested at the hospital where the patient is being seen, a few drops of synovial fluid will be used on the strip.
Synovial PCR for Kingella kingae
In participants \< 8 years old, a sample of synovial fluid will be tested for Kingella kingae using PCR.
Serum Cell count + differential (CBC)
A blood test performed at the hospital.
Serum erythrocyte sedimentation rate (ESR)
A blood test performed at the hospital.
Serum C-reactive Protein (CRP)
A blood test performed at the hospital.
Serum D-dimer
A blood test performed at the hospital.
Serum Procalcitonin
A blood test performed at the hospital.
Blood Cultures
Blood will be cultured at the hospital to see if any organisms grow.
Optional blood testing per standard of care (ASO, anti-strep, ANA, anti-DS-DNA, HLA-B27, RF, Lyme and other inflammatory/ rheumatologic markers )
In patients with suspected inflammation/infection, there are other blood tests which may be standard of care and used for diagnosis.
RECRUITING
Hospital for Special Surgery, New York
RECRUITING
Children's Healthcare of Atlanta, Atlanta
NOT_YET_RECRUITING
Campbell Clinic, Collierville
Collaborators (2)
Pediatric Orthopaedic Society of North America
OTHER
Children's Healthcare of Atlanta
OTHER
Campbell Clinic
OTHER
CD Diagnostics
INDUSTRY
Hospital for Special Surgery, New York
OTHER