NCT03697681View on ClinicalTrials.gov

Protective Effect of Tranexamic Acid on Shedding of the Endothelial Glycocalyx in Patients Undergoing Spinal Fusion Surgery

NACompletedINTERVENTIONAL
Enrollment

128

Participants

Timeline

Start Date

October 16, 2018

Primary Completion Date

August 12, 2020

Study Completion Date

August 12, 2020

Conditions
Posterior Lumbar Spinal Fusion Surgery
Interventions
DRUG

Tranexamic acid

Intravenous infusion of Tranexamic acid(mixed with normal saline) at the dose of 10mg/kg(body weight) for 20 min after induction of anesthesia and then administration another 1mg/kg/hr(body weight) of Tranexamic acid(mixed with normal saline) until the end of the operation.

DRUG

0.9% NaCl (normal saline)

The same amount of normal saline solution without the addition of tranexamic acid is administered in the same manner as the experimental group(Tranexamic acid intervention group).

Trial Locations (1)

03722

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul

All Listed Sponsors
lead

Yonsei University

OTHER

NCT03697681 - Protective Effect of Tranexamic Acid on Shedding of the Endothelial Glycocalyx in Patients Undergoing Spinal Fusion Surgery | Biotech Hunter | Biotech Hunter