10
Participants
Start Date
October 30, 2018
Primary Completion Date
February 24, 2020
Study Completion Date
February 24, 2020
Pulmonary Function Testing
Subjects will undergo spirometry, Plethysmography, and diffusion capacity.
Electrocardiogram
Subjects will undergo an electrocardiogram to ensure sinus rhythm
Cardiac Magnetic Resonance Imaging
Subjects will undergo positron magnetic resonance imaging to detect images of the heart
Metoprolol
Subjects will receive intravenous metoprolol. Dose titrated 1-5 mg every 2 minutes to achieve goal heart rate of 55-65 beats per minute, or for subjects with a resting heart rate already at goal, titrated to achieve a 10-15% reduction in heart rate.
Sildenafil
Subjects will receive a 50 milligram tablet of sildenafil (to be taken orally)
University of Wisconsin-Madison School of Medicine and Public Health, Madison
National Center for Advancing Translational Sciences (NCATS)
NIH
University of Wisconsin, Madison
OTHER