Induced Suppression of Platelets Activity in Aneurysmal SAH Management (iSPASM)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

January 24, 2019

Primary Completion Date

July 1, 2020

Study Completion Date

July 1, 2021

Conditions
Subarachnoid Hemorrhage, Aneurysmal
Interventions
DRUG

tirofiban hydrochloride (AGGRASTAT®)

Participants will have intravenous Aggrastat administered continuously over the course of 7 days in the setting of subarachnoid hemorrhage at least 12 hours post clinically indicated Endovascular Coil Embolization procedure.

DIAGNOSTIC_TEST

MRI

Participants will undergo 2 MRIs administered within 24 hours post Coil Embolization procedure and prior to discharge to monitor for ischemic changes.

DIAGNOSTIC_TEST

Neurological Exam

Neurological exams will be done at screening, randomization, days 2-7, discharge, 6 week, 6 month, and one year follow up visits.

BEHAVIORAL

Questionnaires

Quality of Life in Brain Injury - Overall Scale (QOLIBRI-OS) and the Lawton Instrumental Activities of Daily Living (IADL) will be administered at 6 month and 1 year follow up visits.

DIAGNOSTIC_TEST

Vital Signs

Vital signs which include temperature, respiration rate, blood pressure and O2 stats will be done at screening, randomization, days 2-7, discharge, 6 week, 6 month, and one year follow up visits.

OTHER

Standard of Care Treatment

Participants will receive standard of care treatment and will not receive study drug.

Trial Locations (1)

52242

University of Iowa, Iowa City

All Listed Sponsors
lead

David Hasan

OTHER

NCT03691727 - Induced Suppression of Platelets Activity in Aneurysmal SAH Management (iSPASM) | Biotech Hunter | Biotech Hunter