1,397
Participants
Start Date
June 1, 2018
Primary Completion Date
June 1, 2018
Study Completion Date
September 26, 2018
Fractional flow reserve, coronary flow reserve, and index of microcirculatory resistance
The pressure sensor was positioned at the distal segment of a target vessel, and intracoronary nitrate was administered before each physiologic measurement. To derive resting mean transit time (Tmn), a thermodilution curve was obtained by using 3 injections (3-4 mL each) of room-temperature saline. Hyperemic proximal aortic pressure (Pa), distal arterial pressure (Pd), and hyperemic Tmn were measured during sustained hyperemia. CFR was calculated as resting Tmn/hyperemic Tmn. FFR was calculated as the lowest average of 3 consecutive beats during hyperemia. The uncorrected IMR was calculated by Pd × Tmn during hyperaemia. All IMR values were corrected by Yong's formula (Pa × Tmn × (\[1.35 × Pd/Pa\] - 0.32).
Tokyo Medical and Dental University, Tokyo
Samsung Medical Center, Seoul
Seoul National University Hospital, Seoul
Hospital Clinico San Carlos, Madrid, Spain, Madrid
Samsung Medical Center
OTHER
Tsuchiura Kyodo General Hospital
OTHER
Hospital San Carlos, Madrid
OTHER
Imperial College Healthcare NHS Trust
OTHER
Tokyo Medical and Dental University
OTHER
Sungkyunkwan University
OTHER
Inje University
OTHER
Keimyung University Dongsan Medical Center
OTHER
Ulsan University Hospital
OTHER
Seoul National University Hospital
OTHER