A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

187

Participants

Timeline

Start Date

October 5, 2018

Primary Completion Date

August 19, 2020

Study Completion Date

July 31, 2026

Conditions
Differentiated Thyroid Cancer
Interventions
DRUG

Cabozantinib

Tablets containing 60-mg or 20-mg cabozantinib once daily orally.

DRUG

Placebo

Tablets containing placebo equivalent of 60-mg or 20-mg cabozantinib once daily orally.

Trial Locations (164)

704

Exelixis Clinical Site #136, Tainan City

1070

Exelixis Clinical Site #90, Anderlecht

1090

Exelixis Clinical Site #119, Vienna

1122

Exelixis Clinical Site #46, Budapest

1200

Exelixis Clinical Site #31, Brussels

2065

Exelixis Clinical Site #17, St Leonards

2298

Exelixis Clinical Site #25, Waratah

2650

Exelixis Clinical Site #26, Edegem

Exelixis Clinical Site #74, Edegem

3004

Exelixis Clinical Site #24, Melbourne

4029

Exelixis Clinical Site #12, Herston

4933

Exelixis Clinical Site #45, Angers

5000

Exelixis Clinical Site #27, Namur

5020

Exelixis Clinical Site #62, Salzburg

5042

Exelixis Clinical Site #86, Bedford Park

7624

Exelixis Clinical Site #37, Pécs

9000

Exelixis Clinical Site #100, Ghent

10000

Exelixis Clinical Site #137, Zagreb

Exelixis Clinical Site #138, Zagreb

10002

Exelixis Clinical Site #77, Taipei

10126

Exelixis Clinical Site #120, Torino

10330

Exelixis Clinical Site #122, Pathum Wan

10400

Exelixis Clinical Site #141, Ratchathewi

10408

Exelixis Clinical Site #79, Gyeonggi-do

10700

Exelixis Clinical Site #126, Bangkok Noi

11490

Exelixis Clinical Site #101, Taipei

13915

Exelixis Clinical Site #72, Marseille

15232

Exelixis Clinical Site #75, Pittsburgh

16132

Exelixis Clinical Site #144, Genova

18015

Exelixis Clinical Site #5, Bethlehem

19104

Exelixis Clinical Site #1, Philadelphia

20010

Exelixis Clinical Site #4, Washington D.C.

20089

Exelixis Clinical Site #143, Rozzano

20133

Exelixis Clinical Site #103, Milan

20141

Exelixis Clinical Site #110, Milan

20149

Exelixis Clinical Site #115, Milan

20246

Exelixis Clinical Site #159, Hamburg

21079

Exelixis Clinical Site #32, Dijon

25030

Exelixis Clinical Site #102, Besançon

27710

Exelixis Clinical Site #19, Durham

28027

Exelixis Clinical Site #114, Madrid

28033

Exelixis Clinical Site #30, Madrid

28034

Exelixis Clinical Site #13, Madrid

28040

Exelixis Clinical Site #16, Madrid

28041

Exelixis Clinical Site #33, Madrid

28046

Exelixis Clinical Site #73, Madrid

28050

Exelixis Clinical Site #23, Madrid

28204

Exelixis Clinical Site #76, Charlotte

29010

Exelixis Clinical Site #81, Málaga

29038

Exelixis Clinical Site #158, Tuxtla Gutiérrez

29425

Exelixis Clinical Site #134, Charleston

30625

Exelixis Clinical Site #163, Hanover

31000

Exelixis Clinical Site #145, Osijek

32804

Exelixis Clinical Site #93, Orlando

33075

Exelixis Clinical Site #67, Bordeaux

33136

Exelixis Clinical Site #94, Miami

33612

Exelixis Clinical Site #6, Tampa

35043

Exelixis Clinical Site #125, Marburg

35128

Exelixis Clinical Site #123, Padua

37232

Exelixis Clinical Site #68, Nashville

39120

Exelixis Clinical Site #124, Magdeburg

40536

Exelixis Clinical Site #54, Lexington

45147

Exelixis Clinical Site #154, Essen

45219

Exelixis Clinical Site #7, Cincinnati

47017

Exelixis Clinical Site #132, Meldola

48109

Exelixis Clinical Site #80, Ann Arbor

48201

Exelixis Clinical Site #78, Detroit

48202

Exelixis Clinical Site #22, Detroit

49267

Exelixis Clinical Site #70, Busan

52074

Exelixis Clinical Site #155, Aachen

53100

Exelixis Clinical Site #111, Siena

53127

Exelixis Clinical Site #131, Bonn

56124

Exelixis Clinical Site #29, Pisa

60637

Exelixis Clinical Site #164, Chicago

63110

Exelixis Clinical Site #42, St Louis

65212

Exelixis Clinical Site #63, Columbia

67065

Exelixis Clinical Site #95, Strasbourg

68114

Exelixis Clinical Site #11, Omaha

69373

Exelixis Clinical Site #91, Lyon

71004

Exelixis Clinical Site #112, Tainan City

72076

Exelixis Clinical Site #121, Tübingen

75013

Exelixis Clinical Site #152, Paris

77030

Exelixis Clinical Site #8, Houston

78200

Exelixis Clinical Site #161, San Luis Potosí City

79106

Exelixis Clinical Site #160, Freiburg im Breisgau

80045

Exelixis Clinical Site #9, Aurora

80131

Exelixis Clinical Site #108, Napoli

Exelixis Clinical Site #56, Napoli

81377

Exelixis Clinical Site #139, München

90110

Exelixis Clinical Site #130, Hat Yai

90502

Exelixis Clinical Site #3, Torrance

92658

Exelixis Clinical Site #2, Newport Beach

94115

Exelixis Clinical Site #69, San Francisco

94305

Exelixis Clinical Site #10, Stanford

94805

Exelixis Clinical Site #44, Villejuif

95029

Exelixis Clinical Site #109, Viagrande

95122

Exelixis Clinical Site #135, Catania

95817

Exelixis Clinical Site #98, Sacramento

97080

Exelixis Clinical Site #156, Würzburg

98109

Exelixis Clinical Site #113, Seattle

117036

Exelixis Clinical Site #49, Moscow

121309

Exelixis Clinical Site #53, Moscow

125284

Exelixis Clinical Site #84, Moscow

150054

Exelixis Clinical Site #66, Yaroslavl

155478

Exelixis Clinical Site #85, Moscow

198255

Exelixis Clinical Site #89, Saint Petersburg

200385

Exelixis Clinical Site #150, Craiova

249036

Exelixis Clinical Site #48, Obninsk

300166

Exelixis Clinical Site #142, Timișoara

305524

Exelixis Clinical Site #55, Kislino

400015

Exelixis Clinical Site #149, Cluj-Napoca

443031

Exelixis Clinical Site #52, Samara

625041

Exelixis Clinical Site #157, Tyumen

644013

Exelixis Clinical Site #106, Omsk

3109601

Exelixis Clinical Site #43, Haifa

4941492

Exelixis Clinical Site #58, Petah Tikva

9112001

Exelixis Clinical Site #41, Jerusalem

06510

Exelixis Clinical Site #21, New Haven

02114

Exelixis Clinical Site #153, Boston

07962

Exelixis Clinical Site #118, Morristown

B2700CPM

Exelixis Clinical Site #96, Pergamino

C1012AAR

Exelixis Clinical Site #97, Caba

X5000AVE

Exelixis Clinical Site #129, Córdoba

85806-300

Exelixis Clinical Site #35, Cascavel

90035-903

Exelixis Clinical Site #39, Porto Alegre

90050-170

Exelixis Clinical Site #140, Porto Alegre

90110-270

Exelixis Clinical Site #38, Porto Alegre

14051-140

Exelixis Clinical Site #116, Ribeirão Preto

15090-000

Exelixis Clinical Site #40, São José do Rio Preto

20231-050

Exelixis Clinical Site #92, Rio de Janeiro

01246-000

Exelixis Clinical Site #47, São Paulo

T2N 4N2

Exelixis Clinical Site #20, Calgary

T6G 1Z2

Exelixis Clinical Site #18, Edmonton

N6A 5W9

Exelixis Clinical Site #107, London

M5G 2M9

Exelixis Clinical Site #83, Toronto

656 53

Exelixis Clinical Site #105, Brno

779 00

Exelixis Clinical Site #104, Olomouc

06189

Exelixis Clinical Site #82, Nice

01307

Exelixis Clinical Site #151, Dresden

Unknown

Exelixis Clinical Site #28, Hong Kong

00144

Exelixis Clinical Site #87, Roma

00161

Exelixis Clinical Site #127, Roma

06100

Exelixis Clinical Site #133, Ciudad de Mèxico

03100

Exelixis Clinical Site #147, Mexico City

06700

Exelixis Clinical Site #148, Mexico City

1081 HV

Exelixis Clinical Site #128, Amsterdam

2333 ZA

Exelixis Clinical Site #117, Leiden

60-355

Exelixis Clinical Site #59, Poznan

02-781

Exelixis Clinical Site #15, Warsaw

44-101

Exelixis Clinical Site #61, Gliwice

011863

Exelixis Clinical Site #146, Bucharest

03080

Exelixis Clinical Site #36, Seoul

05505

Exelixis Clinical Site #34, Seoul

08035

Exelixis Clinical Site #14, Barcelona

08036

Exelixis Clinical Site #99, Barcelona

B15 2TH

Exelixis Clinical Site #88, Birmingham

BS2 8ED

Exelixis Clinical Site #71, Bristol

SW3 6JJ

Exelixis Clinical Site #162, London

OX3 7LE

Exelixis Clinical Site #51, Oxford

AB25 2ZN

Exelixis Clinical Site #64, Aberdeen

G12 0YN

Exelixis Clinical Site #50, Glasgow

CF14 2TL

Exelixis Clinical Site #60, Cardiff

M20 4BX

Exelixis Clinical Site #65, Manchester

S10 2SJ

Exelixis Clinical Site #57, Sheffield

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Ipsen

INDUSTRY

lead

Exelixis

INDUSTRY