Ramucirumab and Atezolizumab After Progression on Any Immune Checkpoint Blocker in NSCLC

PHASE2CompletedINTERVENTIONAL
Enrollment

21

Participants

Timeline

Start Date

June 5, 2019

Primary Completion Date

July 16, 2021

Study Completion Date

April 22, 2024

Conditions
Non-small Cell Lung CancerNon Small Cell Lung CancerNSCLC
Interventions
DRUG

Ramucirumab

Ramucirumab is an investigational agent for this trial and will be supplied by Lilly Oncology, free of charge to the patient.

DRUG

Atezolizumab

The initial dose will be administered over 60 minutes (+/- 15 minutes). If the first infusion is tolerated without infusion-associated events, the second infusion may be delivered over 30 minutes (+/- 10 minutes).

PROCEDURE

Peripheral blood draw

-Baseline and Cycle 2 Day 1

PROCEDURE

Biopsy

"* If archival biopsy tissue not available, participant will undergo biopsy at baseline~* When feasible, a repeated tumor biopsy will be obtained between Cycles 2 and 3 after the scheduled CT scan."

Trial Locations (1)

63110

Washington University School of Medicine, St Louis

All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

lead

Washington University School of Medicine

OTHER

NCT03689855 - Ramucirumab and Atezolizumab After Progression on Any Immune Checkpoint Blocker in NSCLC | Biotech Hunter | Biotech Hunter