A Study to Investigate the Safety and Efficacy of ABBV-105 Alone or in Combination With Upadacitinib (ABBV-599 Combination) in Participants With Active Rheumatoid Arthritis

PHASE2CompletedINTERVENTIONAL
Enrollment

242

Participants

Timeline

Start Date

October 8, 2018

Primary Completion Date

March 26, 2020

Study Completion Date

March 26, 2020

Conditions
Rheumatoid Arthritis (RA)
Interventions
DRUG

Elsubrutinib

Elsubrutinib capsule will be administered orally.

DRUG

Upadacitinib

Upadacitinib tablet will be administered orally.

DRUG

Placebo for elsubrutinib

Placebo capsule for elsubrutinib will be administered orally.

DRUG

Placebo for upadacitinib

Placebo tablet for upadacitinib will be administered orally.

Trial Locations (115)

1027

Revita Reumatologiai Rendelo /ID# 202438, Budapest

1070

CUB Hospital Erasme /ID# 201965, Brussels

1200

Cliniques Universitaires Saint Luc /ID# 201756, Woluwe-Saint-Lambert

3000

UZ Leuven /ID# 201927, Leuven

3529

CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 202439, Miskolc

4400

Szabolcs-Szatmar-Bereg Megyei Korhazak & Egyetemi Oktatokorhaz /ID# 202441, Nyíregyháza

8000

CMED Rehabilitacios es Diagnosztikai Kozpont /ID# 205804, Székesfehérvár

8200

Vital Medical Center Orvosi-es Fogaszati Kozpont /ID# 202437, Veszprém

9000

UZ Ghent /ID# 201757, Ghent

15006

Hospital Universitario A Coruña - CHUAC /ID# 202140, A Coruña

18014

Hospital Universitario Virgen de las Nieves /ID# 209705, Granada

19610

Clinical Research Ctr Reading /ID# 170708, Wyomissing

19958

Rheumatology Consultants of De /ID# 208238, Lewes

25801

Rheumatology and Pulmonary cli /ID# 170863, Beckley

27704

EmergeOrtho, P.A. /ID# 209154, Durham

28040

Hospital Clinico Universitario San Carlos /ID# 202135, Madrid

28451

Cape Fear Arthritis Care /ID# 167413, Leland

29010

Hospital Regional de Malaga /ID# 202137, Málaga

32132

Riverside Clinical Research /ID# 167982, Edgewater

32174

International Medical Research - Ormond /ID# 170864, Ormond Beach

Millennium Research /ID# 167453, Ormond Beach

32806

Rheum Assoc of Central FL /ID# 170858, Orlando

32819

HMD Research LLC /ID# 208381, Orlando

33014

Lakes Research, LLC /ID# 170660, Miami

33324

Integral Rheumatology & Immunology Specialists /ID# 206724, Plantation

33511

Bay Area Arthritis and Osteo /ID# 208111, Brandon

33542

Florida Medical Clinic /ID# 206279, Zephyrhills

33705

BayCare Medical Group /ID# 170860, St. Petersburg

St. Anthony Comprehensive Rese /ID# 170668, St. Petersburg

33765

Clinical Res of West FL, Inc. /ID# 167462, Clearwater

34102

Medallion Clinical Research Institute, LLC /ID# 201710, Naples

34684

Arthritis Center, Inc. /ID# 170695, Palm Harbor

35801

Rheum Assoc of North Alabama /ID# 167382, Huntsville

37203

Nashville Arthritis and Rheumatology /ID# 206699, Nashville

38305

West Tennessee Research Inst /ID# 167366, Jackson

38801

North Mississippi Med Clinics /ID# 167377, Tupelo

39008

Hospital Unversitario Marques de Valdecilla /ID# 202133, Santander

39402

Arthritis Associates /ID# 209075, Hattiesburg

46026

Hospital Universitario y Politecnico La Fe /ID# 202139, Valencia

48013

Hospital Universitario Basurto /ID# 206462, Bilbao

48910

June DO, PC /ID# 170670, Lansing

48917

Beals Instititute /ID# 170658, Lansing

53132

Aurora Rheumatology and Immunotherapy Center /ID# 167385, Franklin

60061

Deerbrook Medical Associates /ID# 207098, Vernon Hills

60076

Clinical Investigation Specialists - Skokie /ID# 167468, Skokie

60640

Great Lakes Clinical Trials /ID# 167471, Chicago

67205

PRN of Kansas /ID# 167985, Wichita

68516

Physician Research Collaboration, LLC /ID# 200480, Lincoln

71203

The Arthritis & Diabetes Clinic, Inc. /ID# 170682, Monroe

75007

Trinity Universal Res Assoc /ID# 209252, Carrollton

75150

SW Rheumatology Res. LLC /ID# 167383, Mesquite

75231

Metroplex Clinical Research /ID# 167458, Dallas

76710

Arthritis & Osteoporosis Clinic /ID# 167407, Waco

77004

Rheumatic Disease Clin Res Ctr /ID# 167474, Houston

77065

Rheumatology Clinic of Houston /ID# 203689, Houston

77089

Accurate Clinical Research /ID# 207059, Houston

77375

DM Clinical Research /ID# 167444, Tomball

77845

Arth and Osteo Clin Brazo Valley /ID# 209401, College Station

78215

Sun Research Institute /ID# 170667, San Antonio

78229

Accurate Clinical Management /ID# 200481, San Antonio

78745

Tekton Research, Inc. /ID# 167475, Austin

79124

Amarillo Ctr for Clin Research /ID# 200484, Amarillo

83404

Institute of Arthritis Researc /ID# 170694, Idaho Falls

85032

AZ Arthritis and Rheum Researc /ID# 167448, Phoenix

85210

AZ Arthritis & Rheum Research /ID# 167446, Mesa

85381

SunValley Arthritis Center, Lt /ID# 213073, Peoria

88011

Arthritis and Osteo Assoc /ID# 167443, Las Cruces

90606

Medvin Clinical Research /ID# 205731, Whittier

90720

Valerius Medical Group /ID# 168123, Los Alamitos

91786

Inland Rheum Clin Trials Inc. /ID# 167459, Upland

91942

Purushotham, Akther & Roshan K /ID# 168121, La Mesa

92835

St. Joseph Heritage Healthcare /ID# 167379, Fullerton

95661

Sierra Rheumatology /ID# 167976, Roseville

98021

Western Washington Arthritis C /ID# 205821, Bothell

99204

Arthritis Northwest, PLLC /ID# 200479, Spokane

92128-2549

Rheumatology Center of San Diego /ID# 170690, San Diego

95382-2007

Iraj Sabahi Research, Inc /ID# 201923, Turlock

32713-2260

Omega Research Maitland, LLC /ID# 167376, DeBary

33185-5948

Kendall South Medical Center, Inc. /ID# 206857, Miami

33606-1246

Clinical Research of West Florida, Inc /ID# 169099, Tampa

33613-1244

ForCare Clinical Research /ID# 206280, Tampa

02048

Mansfield Health Center /ID# 167372, Mansfield

01605

Advanced Clinical Care /ID# 167367, Worcester

63119-3845

Clayton Medical Associates dba Saint Louis Rheumatology /ID# 170650, St Louis

03756

Dhmc /Id# 167476, Lebanon

08755

Ocean Rheumatology /ID# 170673, Toms River

28210-8508

DJL Clinical Research, PLLC /ID# 167374, Charlotte

45242-3763

New Horizons Clinical Research /ID# 170862, Blue Ash

45750-1635

Marietta Memorial Hospital /ID# 210968, Marietta

45377-9464

STAT Research, Inc. /ID# 200485, Vandalia

73103-2400

Health Research of Oklahoma /ID# 167370, Oklahoma City

79410-1198

West Texas Clinical Research /ID# 205732, Lubbock

75024-5283

Trinity Universal Research Association /ID# 209253, Plano

23606-4434

Tidewater Physicians Medical Center /ID# 210884, Newport News

T5M 0H4

Rheumatology Research Assoc /ID# 207299, Edmonton

R3A 1M3

Manitoba Clinic /ID# 202126, Winnipeg

R3N 0K6

CIADS Research Co Ltd /ID# 202125, Winnipeg

L5M 2V8

Credit Valley Rheumatology /ID# 202124, Mississauga

M5G 1X5

Mount Sinai Hosp.-Toronto /ID# 202652, Toronto

S7K 3H3

Dr. Latha Naik /ID# 212972, Saskatoon

586 01

Revmatolog s.r.o. /ID# 202610, Jihlava

128 00

Revmatologicky ustav Praha /ID# 202142, Prague

702 00

Revmatologie MUDr. Klara Sirova /ID# 205185, Ostrava

530 02

CCR Czech a.s /ID# 202144, Pardubice

30-149

Malopolskie Centrum Kliniczne /ID# 206473, Krakow

05-825

McBk Sc /Id# 212575, Grodzisk Mazowiecki

00-465

NBR Polska /ID# 206476, Warsaw

15-879

ClinicMed Daniluk, Nowak Sp.j. /ID# 212576, Bialystok

02-691

Reumatika - Centrum Reumatologii NZOZ /ID# 206472, Warsaw

00909

GCM Medical Group, PSC /ID# 167983, San Juan

08036

Hospital Clinic /ID# 206575, Barcelona

08041

Hospital Santa Creu i Sant Pau /ID# 206535, Barcelona

NE1 4LP

The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 201976, Newcastle upon Tyne

OX3 7LF

University of Oxford /ID# 201974, Oxford

WA5 1LZ

Warrington and Halton Teaching Hosp NHS Foundation Trust /ID# 206002, Warrington

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AbbVie

INDUSTRY