16
Participants
Start Date
January 8, 2018
Primary Completion Date
May 5, 2018
Study Completion Date
May 5, 2018
Control: Lacated Ringers
This site will serve as the control site
Apocynin
This site will be used to inhibit NADPH oxidase and subsequent production of superoxide.
Allopurinol
This site will be use to inhibit xanthine oxidase and subsequent production of superoxide.
BH4
This site will be use to locally supplement BH4.
NG Nitro L Arginine Methyl Ester
L-Name is a NOS inhibitor that is administered to each site to allow for the quantification of NO contribution to vasodilation. The infusion rate will be 2 µl/min
Sodium Nitroprusside
SNP will be perfused through each site to induce maximal vasodilation. The infusion rate will be 2 µl/min
Acetyl-ß-methylcholine chloride
Mch is an acetylcholine analog that causes endothelial dependent vasodilation primarily through stimulation of NO production.
Engineering Research Building, Arlington
The University of Texas at Arlington
OTHER