24
Participants
Start Date
October 1, 2018
Primary Completion Date
February 1, 2020
Study Completion Date
February 1, 2020
Control (Phenylephrine)
This intervention is aimed at assessing the vascular responsiveness to phenylephrine, an alpha 1-agonist, in white and black men and women across a series of ascending dose concentrations.
Phenylephrine + Apocynin
This intervention is meant to assess the impact of NADPH oxidase-derived superoxide on vasoconstrictor responses by inhibiting the enzyme NADPH oxidase.
Phenylephrine + Allopurinol
This intervention is meant to assess the impact of xanthine oxidase-derived superoxide on vasoconstrictor responses by inhibiting the enzyme xanthine oxidase.
Phenylephrine + Tempol
This intervention is meant to assess the impact of superoxide on vasoconstrictor responses by scavenging available superoxide.
Science and Engineering Research and Innovation Building, Arlington
The University of Texas at Arlington
OTHER