Evaluation of Anti-biofilm Effects of Ferumoxytol (Feraheme) Using an in Situ Biofilm Demineralization Model

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

June 7, 2018

Primary Completion Date

August 16, 2018

Study Completion Date

August 16, 2018

Conditions
Dental Caries
Interventions
DRUG

Ferumoxytol/Hydrogen peroxide

1.5% Ferumoxytol / 3% Hydrogen Peroxide (H2O2) 1:1 ratio. Each subject will use this product during one of three treatment periods in the crossover study design.

DRUG

Hydrogen Peroxide

Sham Solution / 3% Hydrogen Peroxide (H2O2) 1:1 ratio. Each subject will use this product during one of three treatment periods in the crossover study design.

DRUG

Water

Sham solution (water; negative control). Each subject will use this product during one of three treatment periods in the crossover study design.

Trial Locations (2)

19104

University of Pennsylvania, School of dental medicine, Philadelphia

46202

Oral Health Research Institute, Indianapolis

All Listed Sponsors
collaborator

Indiana University

OTHER

lead

University of Pennsylvania

OTHER

NCT03678012 - Evaluation of Anti-biofilm Effects of Ferumoxytol (Feraheme) Using an in Situ Biofilm Demineralization Model | Biotech Hunter | Biotech Hunter