A Phase III Study to Evaluate the Port Delivery System With Ranibizumab Compared With Monthly Ranibizumab Injections in Participants With Wet Age-Related Macular Degeneration

PHASE3CompletedINTERVENTIONAL
Enrollment

415

Participants

Timeline

Start Date

September 12, 2018

Primary Completion Date

May 22, 2020

Study Completion Date

June 9, 2021

Conditions
Neovascular Age-Related Macular Degeneration
Interventions
DRUG

PDS Implant filled with 100 mg/mL Ranibizumab

Will be administered as per the schedule described in individual arm.

DRUG

Intravitreal Injections of 10 mg/mL Ranibizumab

Will be administered as per the schedule described in individual arm.

Trial Locations (77)

10022

Vitreous-Retina-Macula, New York

11021

Long Is. Vitreoretinal Consult, Great Neck

11570

Ophthalmic Consultants of Long Island, Rockville Centre

13088

Retina Vit Surgeons/Central NY, Liverpool

20815

Retina Group of Washington, Chevy Chase

21204

Retina Specialists, Towson

21209

The Retina Care Center, Baltimore

21287

Johns Hopkins Med; Wilmer Eye Inst, Baltimore

23235

Retina Institute of Virginia, Richmond

23502

Wagner Macula & Retina Center, Norfolk

28210

Char Eye Ear &Throat Assoc, Charlotte

29501

Palmetto Retina Center, Florence

30060

Georgia Retina PC, Marietta

30909

Southeast Retina Center, Augusta

32308

Southern Vitreoretinal Assoc, Tallahassee

32503

Retina Specialty Institute, Pensacola

32901

Florida Eye Associates, Melbourne

33324

Fort Lauderdale Eye Institute, Plantation

33410

Retina Care Specialists, Palm Beach Gardens

33609

Retina Associates of Florida, LLC, Tampa

33711

Retina Vitreous Assoc of FL, St. Petersburg

33912

National Ophthalmic Research Institute, Fort Myers

37203

Tennessee Retina PC, Nashville

38119

Charles Retina Institute, Memphis

40509

Retina Associates of Kentucky, Lexington

42001

Paducah Retinal Center, Paducah

43212

OSU Eye Physicians & Surgeons, Columbus

44195

The Cleveland Clinic Foundation, Cleveland

45242

Cincinnati Eye Institute, Cincinnati

49546

Associated Retinal Consultants, Grand Rapids

Foundation for Vision Research, Grand Rapids

50266

Wolfe Eye Clinic, West Des Moines

55435

VitreoRetinal Surgery, PLLC.; DBA Retina Consultants of Minnesota, Edina

60435

Illinois Retina Associates, Joliet

60439

University Retina and Macula Associates, PC, Lemont

63017

Midwest Vision Research Foundation, Chesterfield

The Retina Institute - Chesterfield, Chesterfield

66215

Retina Associates, Lenexa

73013

Retina Vitreous Center, Edmond

76012

Texas Retina Associates, Arlington

76104

Texas Retina Associates, Fort Worth

77401

Retina Consultants of Texas, Bellaire

78240

Med Center Ophthalmology Assoc, San Antonio

78705

Austin Retina Associates, Austin

78750

Austin Clinical Research LLC, Austin

80228

Colorado Retina Associates, PC, Lakewood

80528

Eye Center of Northern CO, Fort Collins

81303

Southwest Retina Consultants, Durango

84107

Retina Associates of Utah, Salt Lake City

Rocky Mountain Retina, Salt Lake City

85020

Associated Retina Consultants, Phoenix

85021

Arizona Retina and Vitreous Consultants, Phoenix

85053

Retinal Consultants of Arizona, Phoenix

85206

Barnet Dulaney Perkins Eye Center, Mesa

89502

Sierra Eye Associates, Reno

90211

Retina-Vitreous Associates Medical Group, Beverly Hills

91436

The Retina Partners, Encino

92064

Retina Consultants, San Diego, Poway

92705

Orange County Retina Med Group, Santa Ana

93103

California Retina Consultants, Santa Barbara

93309

California Retina Consultants, Bakersfield

94040

N CA Retina Vitreous Assoc, Mountain View

94109

West Coast Retina Medical Group, San Francisco

94143

UCSF; Ophthalmology, San Francisco

94598

Bay Area Retina Associates, Walnut Creek

95825

Retinal Consultants Med Group, Sacramento

97221

Retina Northwest, Portland

98383

Retina Center Northwest, Silverdale

99204

Spokane Eye Clinical Research, Spokane

90095-7000

Jules Stein Eye Institute/ UCLA, Los Angeles

06385

Retina Group of New England, Waterford

04101

Maine Eye Center, Portland

02114

Ophthalmic Consultants of Boston, Boston

01605

Vitreo-Retinal Associates, PC, Worcester

07003

Envision Ocular, LLC, Bloomfield

08034

Mid Atlantic Retina - Wills Eye Hospital, Cherry Hill

08755

NJ Retina Teaneck Clinic, Toms River

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT03677934 - A Phase III Study to Evaluate the Port Delivery System With Ranibizumab Compared With Monthly Ranibizumab Injections in Participants With Wet Age-Related Macular Degeneration | Biotech Hunter | Biotech Hunter