10,498
Participants
Start Date
February 5, 2018
Primary Completion Date
March 10, 2020
Study Completion Date
March 10, 2020
SANDWICH protocol
A protocol based intervention incorporating co-ordinated care with greater nursing involvement; patient-relevant sedation plans linked to regular assessment using the COMFORT scale; regular assessment of ventilation parameters with a higher than usual trigger for undertaking an extubation readiness test; a spontaneous breathing trial (SBT) on low levels of respiratory support to test extubation readiness
Usual care
Usual sedation and weaning management that is not protocol based
Belfast Health and Social Care Trust, Belfast
Alder Hey Children's NHS Foundation Trust, Liverpool
University Hospitals of North Midlands NHS Trust, Stoke
Birmingham Women and Children's NHS Foundation Trust, Birmingham
University Hospital Bristol NHS Foundation Trust, Bristol
Cambridge University Hospitals NHS Foundation Trust, Cambridge
Cardiff and Vale University Health Board, Cardiff
Leeds Teaching Hospitals Trust, Leeds
Kings College Hospital NHS Foundation Trust, London
St George's University Hospitals NHS Foundation Trust, London
Royal Brompton and Harefield NHS Foundation Trust, London
Imperial College Healthcare NHS Trust, London
Great Ormond Street Hospital NHS Foundation Trust, London
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle
Oxford University Hospital NHS Foundation Trust, Oxford
Sheffield Children's NHS Foundation Trust, Sheffield
University Hospital Southampton Foundation NHS Trust, Southampton
Collaborators (1)
Birmingham Women's and Children's NHS Foundation Trust
OTHER
Royal Brompton & Harefield NHS Foundation Trust
OTHER
University College, London
OTHER
University of Birmingham
OTHER
University of Leeds
OTHER
Northern Ireland Clinical Trials Unit
OTHER
University of the West of England
OTHER
University of Edinburgh
OTHER
Queen's University, Belfast
OTHER