Denosumab and Nivolumab Combination As 2d-line Therapy in Stage IV NSC Lung Cancer with Bone Metastases (DENIVOS)

PHASE2CompletedINTERVENTIONAL
Enrollment

82

Participants

Timeline

Start Date

November 6, 2018

Primary Completion Date

October 19, 2023

Study Completion Date

October 19, 2023

Conditions
Carcinoma, Non-Small-Cell LungBone Metastases
Interventions
DRUG

Denosumab-nivolumab combination

"* Denosumab: 120 mg every 4 weeks subcutaneously~* Nivolumab: 240mg intravenously on day 1 every 2 weeks"

Trial Locations (27)

13003

Hopital Européen, Marseille

13616

CH du Pays d'Aix, Aix-en-Provence

13915

Hopital Nord APHM, Marseille

29609

CHU Morvan - Institut de Cancérologie et d'Hématologie, Brest

33505

Hôpital Robert Boulin, Libourne

35033

CHU Hôpital Pontchailloux, Rennes

42271

Institut de Cancérologie de la Loire, Saint-Priest-en-Jarez

49033

Chu Angers, Angers

60021

Centre Hospitalier de Beauvais, Beauvais

65013

Centre Hospitalier de Bigorre, Tarbes

66000

Centre Catalan d'Oncologie, Perpignan

67000

CLCC Paul Strauss, Strasbourg

69655

CH Villefranche sur Saone, Villefranche-sur-Saône

74374

CH Annecy-Genevois, Pringy

76031

CHU Rouen, Rouen

76503

Ch Intercommunal Elbeuf Louvier Val de Reuil, Elbeuf

77108

CH Meaux, Meaux

77600

CH Marne La Vallée, Marne La Vallée

78157

Hôpital André Mignot Centre Hospitalier de Versailles, Versailles

83041

Hôpital d'Instruction des Armées Saint-Anne, Toulon

83056

CHITS Toulon Sainte-Musse, Toulon

87042

Chu Dupuytren, Limoges

94010

CH Intercommunal, Créteil

97410

Groupe Hospitalier Sud Réunion - CHU de la Réunion, Saint-Pierre

97411

CHU La Réunion - Site de Bellepierre, Saint-Denis

01012

Centre Hospitalier Fleyriat, Bourg-en-Bresse

05000

CH Intercommunal des Alpes du Sud, Gap

All Listed Sponsors
collaborator

French Lung Cancer Group

UNKNOWN

lead

Centre Hospitalier Annecy Genevois

OTHER

NCT03669523 - Denosumab and Nivolumab Combination As 2d-line Therapy in Stage IV NSC Lung Cancer with Bone Metastases (DENIVOS) | Biotech Hunter | Biotech Hunter