The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial

PHASE4CompletedINTERVENTIONAL
Enrollment

1,554

Participants

Timeline

Start Date

November 27, 2018

Primary Completion Date

February 14, 2022

Study Completion Date

November 16, 2022

Conditions
Septic Shock
Interventions
DRUG

Isotonic crystalloids

"Types of fluid to be used in both intervention groups:~* IV fluids given for circulatory impairment: Only isotonic crystalloids are to be used as per the Scandinavian guideline for fluid resuscitation~* Fluids given to substitute overt loss: Isotonic crystalloids are to be used. If large amounts of ascites are tapped, then human albumin may be used~* Fluids used for dehydration: Water or isotonic glucose should be used~* Fluids used for electrolyte disturbances: Fluids should be chosen to substitute the specific deficiency, including water in the case of severe hypernatremia~* Blood products are only to be used on specific indications including severe bleeding, severe anaemia and prophylactic in case of severe coagulopathy"

Trial Locations (31)

2100

Dept of Intensive Care,Copenhagen University Hospital Rigshospitalet, Copenhagen

3400

Dept. of Intensive Care, Hillerød Hospital, Hillerød

Unknown

University Hospital Brussels (UZB), Brussels

Medical Intensive Care Unit, Fakultni Nemocnice, Pilsen

Dept. of Anaesthesia and Intensive Care, Aalborg University Hospital, Denmark., Aalborg

Dept. of Anaesthesia and Intensive Care, Bispebjerg Hospital, Copenhagen

Dept. of Anaesthesia and Intensive Care, Herning Hospital, Herning

Dept. of Anaesthesia and Intensive Care, Holbæk Hospital, Holbæk

Dept. of Anaesthesia and Intensive Care, Lillebaelt Hospital, Kolding

Dept. of Anaesthesia and Intensive Care, Zealand University Hospital Køge, Køge

Dept. of Anaesthesia and Intensive Care, Randers Hospital, Randers

Dept. of Anaesthesia and Intensive Care, Zealand University Hospital Roskilde, Roskilde

Dept. of Anaesthesia and Intensive Care, Viborg Hospital, Viborg

Humanitas research hospital Bergamo, Bergamo

Dept. of Intensive Care, Humanitas Research Hospital Castelanza, Castellanza

Dept. of Intensive Care, Ancona Hospital, Ancona

Dept. of Intensive Care, Humanitas Research Hospital, Milan

Dept. of intensive care, Østfold, Kalnes, Grålum

Dept. of intensive Care, Innlandet Hamar, Hamar

Dept. of Intensive Care Medicine, Stavanger, Stavanger

Dept. of Intensive Care Medicine, St Göran, Gothenburg

Dept. of intensive care, Huddinge, Huddinge

MIMA Medicinsk intermediärvårdsavdelning, Huddinge

Dept. of Intensive Care, Solna, Solna

Medical ICU, Karolinska, Södersjukhuset, Stockholm

Södersjukhuset, Stockholm

Dept. of Intensive Care Medicine Sundsvall Hospital, Sundsvall

Dept. of intensive care, Basel, Basel

Dept. of Intensive Care, University Hospital Bern, Bern

Dept. of Intensive Care Unit, Guy's and St. Thomas' Hospital, London

0450

Dept. of Intensive Care, Oslo University Hospital, Oslo

All Listed Sponsors
collaborator

Rigshospitalet, Denmark

OTHER

collaborator

Centre for Research in Intensive Care (CRIC)

OTHER

collaborator

Scandinavian Critical Care Trials Group

OTHER

lead

Anders Perner, MD, PhD

OTHER

NCT03668236 - The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial | Biotech Hunter | Biotech Hunter