774
Participants
Start Date
February 25, 2021
Primary Completion Date
February 28, 2026
Study Completion Date
February 28, 2026
Trazodone
Trazodone is approved by the Food and Drug Administration (FDA) for treating major depression in adults but not for PTSD. Although trazodone has not been approved by the FDA to treat insomnia or PTSD, some doctors have tried it for these purposes. The doses in this study will be lower than the doses used to treat depression.
Eszopiclone
Eszopiclone is approved by the FDA for treating insomnia, but it's unknown if eszopiclone can help treat insomnia when it's related to PTSD. Some doctors have tried it for this purpose. The doses in this study will be the same as the doses used to treat insomnia. A small study found it to be helpful for treating patients with PTSD.
Placebo
The active study medications listed above will be compared with a placebo, which is a pill that looks like a study medication but has no medication in it.
RECRUITING
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh
RECRUITING
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia
RECRUITING
Salem VA Medical Center, Salem, VA, Salem
ACTIVE_NOT_RECRUITING
Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC, Salisbury
RECRUITING
Asheville VA Medical Center, Asheville, NC, Asheville
RECRUITING
Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur
RECRUITING
Birmingham VA Medical Center, Birmingham, AL, Birmingham
RECRUITING
Tuscaloosa VA Medical Center, Tuscaloosa, AL, Tuscaloosa
RECRUITING
Louis Stokes VA Medical Center, Cleveland, OH, Cleveland
RECRUITING
William S. Middleton Memorial Veterans Hospital, Madison, WI, Madison
RECRUITING
Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis
RECRUITING
Overton Brooks VA Medical Center, Shreveport, LA, Shreveport
RECRUITING
South Texas Health Care System, San Antonio, TX, San Antonio
RECRUITING
VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City
RECRUITING
Phoenix VA Health Care System, Phoenix, AZ, Phoenix
RECRUITING
VA Long Beach Healthcare System, Long Beach, CA, Long Beach
RECRUITING
VA San Diego Healthcare System, San Diego, CA, San Diego
RECRUITING
VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle
TERMINATED
VA Loma Linda Healthcare System, Loma Linda, CA, Loma Linda
TERMINATED
VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto
TERMINATED
San Francisco VA Medical Center, San Francisco, CA, San Francisco
RECRUITING
VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven
RECRUITING
CERC (VISN1, West Haven, CT), West Haven
TERMINATED
Bay Pines VA Healthcare System, Pay Pines, FL, Bay Pines
TERMINATED
Edward Hines Jr. VA Hospital, Hines, IL, Hines
TERMINATED
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston
RECRUITING
New Mexico VA Health Care System, Albuquerque, NM, Albuquerque
TERMINATED
Durham VA Medical Center, Durham, NC, Durham
TERMINATED
Cincinnati VA Medical Center, Cincinnati, OH, Cincinnati
RECRUITING
Providence VA Medical Center, Providence, RI, Providence
RECRUITING
Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston
TERMINATED
VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas
ACTIVE_NOT_RECRUITING
Michael E. DeBakey VA Medical Center, Houston, TX, Houston
RECRUITING
White River Junction VA Medical Center, White River Junction, VT, White River Junction
TERMINATED
Clement J. Zablocki VA Medical Center, Milwaukee, WI, Milwaukee
VA Office of Research and Development
FED