NCT03667157 - Liver Function After Intravenous Methylprednisolone Administration | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

January 1, 2012

Primary Completion Date

October 30, 2016

Study Completion Date

October 30, 2016

Conditions

Graves DiseaseGraves OphthalmopathyLiver DiseasesLiver FailureLiver InjuryLiver DysfunctionLiver InsufficiencyAcute Liver FailureAcute Liver InjuryAcute Liver Injury, Drug InducedMethylprednisolone Adverse ReactionGlucocorticoids ToxicityDysthyroid OrbitopathyDysthyroid Ophthalmopathy

Interventions

DRUG

every week IVMP therapy

12 pulses of intravenous methylprednisolone (IVMP) in every week schedule (for the first 6 weeks 0.5g IVMP per week, for the next 6 weeks 0.25g IVMP per week; cumulative dose 4.5g) according to EUGOGO recommendations

DRUG

very high doses IVMP therapy

3 pulses of intravenous methylprednisolone (IVMP) (1.0g/day for 3 consecutive days; cumulative dose 3.0g) according to EUGOGO recommendations

All Listed Sponsors

lead

Medical University of Warsaw

OTHER