Biomarkers of Response to Pembrolizumab Combined With Chemotherapy in Non-Small Cell Lung Cancer (KEYNOTE-782, MK-3475-782)

PHASE2CompletedINTERVENTIONAL
Enrollment

118

Participants

Timeline

Start Date

October 30, 2018

Primary Completion Date

November 5, 2021

Study Completion Date

November 5, 2021

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Pembrolizumab

Pembrolizumab, 200 mg, Day 1 of each 21-day cycle (Q3W), intravenous infusion (IV), standard of care in most countries

DRUG

Pemetrexed

Pemetrexed, 500 mg/m\^2 infusion, standard of care, Q3W, IV

DRUG

Carboplatin

Carboplatin AUC 5 mg/mL/min, IV infusion, Day 1 of each 21-day cycle for 4 cycles (Cycles 1 - 4). Investigator's choice of either cisplatin or carboplatin.

DRUG

Cisplatin

Cisplatin, 75 mg/m\^2, IV infusion, Day 1 of each 21-day cycle for 4 cycles (Cycles 1 - 4). Investigator's choice of either cisplatin or carboplatin.

Trial Locations (15)

1121

Orszagos Koranyi TBC es Pulmonologiai Intezet ( Site 0400), Budapest

5000

Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 0401), Szolnok

9024

Petz Aladar Megyei Oktato Korhaz ( Site 0402), Győr

21237

Harry & Jeanette Weinberg Cancer Institute ( Site 0901), Baltimore

28041

Hospital General Universitario 12 de Octubre ( Site 0703), Madrid

28222

Hospital Puerta de Hierro ( Site 0702), Majadahonda

33011

Hospital Universitario Central de Asturias ( Site 0704), Oviedo

35001

Hospital Universitario Insular de Gran Canaria ( Site 0700), Las Palmas de Gran Canaria

48202

Henry Ford Health System ( Site 0903), Detroit

80045

University Of Colorado ( Site 0908), Aurora

4428164

Meir Medical Center ( Site 0501), Kfar Saba

5262000

Chaim Sheba Medical Center ( Site 0500), Ramat Gan

K7L 2V7

Kingston General Hospital ( Site 0800), Kingston

J4V 2H1

CISSS de la Monteregie-Centre ( Site 0801), Greenfield Park

08035

H.U. Vall de Hebron ( Site 0701), Barcelona

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03664024 - Biomarkers of Response to Pembrolizumab Combined With Chemotherapy in Non-Small Cell Lung Cancer (KEYNOTE-782, MK-3475-782) | Biotech Hunter | Biotech Hunter