486
Participants
Start Date
March 13, 2019
Primary Completion Date
February 28, 2027
Study Completion Date
May 1, 2028
Intensified protocol
Early Temozolomide (TMZ) 1 cycle (150 mg/m²/ day X 5 days, per os) Started between day 2 and 15 after surgery/ biopsy RT (60 Gy, 2 Gy/fraction) + concomitant TMZ (75 mg/m2/day X 42 days, per os) Started between W4 and W6 after surgery/ biopsy Adjuvant TMZ 6 cycles (150-200 mg/m2 X 5 days /month, per os) Started 1 month after the end of the concomitant TMZ Prolonged TMZ Until progression, intolerance, patient's or physician's decision (150-200 mg/m2 every 4 weeks, per os)
Stupp protocol
RT (60 Gy, 2 Gy/fraction) + concomitant Temozolomide (75 mg/m2/day X 42 days, per os) Started between W4 and W6 after surgery/ biopsy Adjuvant TMZ 6 cycles (150-200 mg/m2 X 5 days /month, per os) Started 1 month after the end of the concomitant TMZ
RECRUITING
CHU La Timone, Marseille
RECRUITING
Centre François Baclesse, Caen
RECRUITING
Centre Georges François Leclerc, Dijon
RECRUITING
ICM Val d'Aurelle, Montpellier
RECRUITING
CHRU Tours, Tours
RECRUITING
CHU Grenoble Alpes, Grenoble
RECRUITING
Institut Cancérologie Loire, Saint-Priest-en-Jarez
WITHDRAWN
ICO Centre René Gauducheau, Nantes
WITHDRAWN
ICO Centre Paul Papin, Angers
RECRUITING
CHRU Nancy, Nancy
RECRUITING
Centre Jean Perrin, Clermont-Ferrand
RECRUITING
Centre Paul Strauss, Strasbourg
RECRUITING
Hôpitaux Civils de Colmar, Colmar
RECRUITING
Centre Léon Bérard, Lyon
RECRUITING
APHP La Pitié Salpêtrière, Paris
RECRUITING
Centre Hospitalier d'Amiens, Amiens
RECRUITING
CHU de Limoges, Limoges
RECRUITING
CH René Dubos, Pontoise
RECRUITING
CHU de Nice - Hôpital de Cimiez, Nice
Association de Neuro-Oncologues d'Expression Francaise
OTHER
Erasme University Hospital
OTHER
Centre Oscar Lambret
OTHER