KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

385

Participants

Timeline

Start Date

January 15, 2019

Primary Completion Date

December 31, 2023

Study Completion Date

December 31, 2025

Conditions
Primary Myelofibrosis (PMF)Post-Polycythemia Vera MF (Post-PV-MF)Post-Essential Thrombocythemia MF (Post-ET-MF)
Interventions
DRUG

KRT-232

KRT-232, administered by mouth

DRUG

Best Available Therapy (BAT)

"Best available therapy options include:~1. hydroxyurea~2. chemotherapy or~3. supportive care (including but not limited to corticosteroids and androgens; JAK inhibitors not allowed)."

Trial Locations (191)

100

RECRUITING

National Taiwan University Hospital, Taipei City

807

RECRUITING

Kaohsiung Medical University - Chung-Ho Memorial Hospital, Kaohsiung City

1000

RECRUITING

University of the Philippines - Philippine General Hospital, Manila

1003

RECRUITING

Hospital San Pedro de Alcantara, Cáceres

1083

WITHDRAWN

Semmelweis Egyetem, Budapest

1425

RECRUITING

Centro Medico San Luis, CABA

1606

RECRUITING

Military Medical Academy, Multiprofile for active treatment, Sofia, Sofia

3168

RECRUITING

Monash Medical Centre, Clayton

3174

RECRUITING

South Eastern Private Hospital, Noble Park

4032

COMPLETED

Debreceni Egyetem Orvos es Egeszsegtudomanyi Centrum, Debrecen

4400

RECRUITING

Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház, Nyíregyháza

6000

RECRUITING

Perpetual Succour Hospital - Hemat/Transfusion Med, Cebu City

6150

RECRUITING

Fiona Stanley Hosital, Murdoch

6591

RECRUITING

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

6725

RECRUITING

Szegedi Tudományegyetem, Szeged

6800

RECRUITING

Oaxaca Site Management Organization OSMO, Oaxaca City

7400

WITHDRAWN

Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár

8041

RECRUITING

Hospital de La Santa Creu i Sant Pau, Barcelona

10000

RECRUITING

Clinical Hospital Centre Osijek, Zagreb

RECRUITING

KB Sestre Milosrdnice, Zagreb

10021

WITHDRAWN

New York Presbyterian/Weill Cornell Medical Center, New York

10029

RECRUITING

Mt. Sinai, New York

10126

RECRUITING

A.O. Citta della Salute e della Scienza di Torino, Torino

10400

RECRUITING

Ramathibodi Hospital - Mahidol University - Hematology, Bangkok

10700

RECRUITING

Siriraj Hospital, Bangkok

11212

RECRUITING

Brookdale University Hospital and Medical Center, Brooklyn

12120

RECRUITING

Thammasat University Hospital, Khlong Luang

13083

RECRUITING

UNICAMP - Universidade Estadual de Campinas Hemocentro, Campinas

13353

RECRUITING

Charité Universitätsmedizin Berlin, Berlin

14000

ACTIVE_NOT_RECRUITING

Centre Hospitalier Universitaire of Caen Normandie - Côte de Nacre, Caen

15121

RECRUITING

PO Civile SS.Antonio e Biagio, Alessandria

20122

RECRUITING

Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda, Milan

20160

RECRUITING

Pamukkale University, Denizli

20162

RECRUITING

ASST Grande Ospedale Metropolitano Niguarda, Milan

20251

RECRUITING

UKE - Universitätsklinikum Hamburg-Eppendorf, Hamburg

20900

RECRUITING

A.O. San Gerardo di Monza - L'Ospedale San Gerardo di Monza e l'Università di Milano, Monza

22000

RECRUITING

General Hospital Sibenik, Šibenik

22100

RECRUITING

Western Galilee Hospital - Nahariya, Nahariya

25123

RECRUITING

AO Spedali Civili di Brescia, Brescia

26504

RECRUITING

University Campus of Patras - Hematology, Pátrai

27100

RECRUITING

Gaziantep University Faculty of Medicine, Gaziantep

28100

RECRUITING

AOU Maggiore della Carità, Novara

28222

ACTIVE_NOT_RECRUITING

Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda

29010

RECRUITING

Hospital Universitario Virgen de la Victoria, Málaga

29609

RECRUITING

Centre Hospitalier Regional Universitaire Brest Hopital Morvan, Brest

31008

RECRUITING

Complejo Hospitalario de Navarra - H. de Navarra, Hematología C/ de Irunlarrea, 3, Pamplona, Pamplona

31059

RECRUITING

Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse

31096

RECRUITING

Rambam Medical Centre, Haifa

33110

RECRUITING

Mersin University Medical Faculty, Mersin

33426

WITHDRAWN

University Cancer Institute, Boynton Beach

35010

RECRUITING

Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria

35294

ACTIVE_NOT_RECRUITING

The Kirklin Clinic of UAB Hospital, Birmingham

37007

RECRUITING

Hospital Universitario de Salamanca, Salamanca

37203

RECRUITING

Vanderbilt University Medical Center, Nashville

40002

RECRUITING

Srinagarind Hospital (KhonKaen University), Khon Kaen

40447

RECRUITING

China Medical University Hospital, Taichung

41038

RECRUITING

A.O.di Bologna Policl.S.Orsola, Bologna

41944

RECRUITING

Kyungpook National University Hospital, Daegu

42123

RECRUITING

Arcispedale S. Maria Nuova, AO di Reggio Emilia, Reggio Emilia

42415

RECRUITING

Yeungnam University Medical Center, Daegu

42601

RECRUITING

Keimyung University Dongsan Medical Center, Daegu

43210

COMPLETED

The Ohio State University Comprehensive Cancer Center, Columbus

44280

RECRUITING

Inonu University Turgut Ozal Medical Center, Malatya

44281

RECRUITING

Hematology Institute, Kfar Saba

44718

RECRUITING

Gabrail Cancer Center, Canton

45147

RECRUITING

Universitaetsklinikum Essen, Essen

45500

RECRUITING

University General Hospital of Ioannina, Ioannina

46017

RECRUITING

Hospital Universitario Doctor Peset, Valencia

47392

RECRUITING

Inje University Busan Paik Hospital, Busan

49100

RECRUITING

Rabin Medical Center - Beilinson Hospital, Petah Tikva

50012

RECRUITING

H. Quirón Zaragoza, Zaragoza

50141

RECRUITING

AOU Careggi, Florence

52074

ACTIVE_NOT_RECRUITING

Universitätsklinikum Aachen, Aachen

53226

RECRUITING

Medical College of Wisconsin - Froedtert Hospital, Milwaukee

54100

RECRUITING

Sakarya Research and Training Hospital, Adapazarı

54636

RECRUITING

AHEPA General Hospital of Thessaloniki, Thessaloniki

55280

RECRUITING

Ondokuz Mayis University Medical Faculty - Hematology, Samsun

57105

RECRUITING

Avera Cancer Institute, Sioux Falls

60123

RECRUITING

AOU Ospedali Riuniti Umberto I G.M. Lancisi G. Salesi, Ancona

60611

COMPLETED

Northwestern University Feinberg School of Medicine, Chicago

60612

RECRUITING

University of Illinois at Chicago, Chicago

61121

RECRUITING

Azienda Ospedaliera Ospedali Riuniti Marche Nord - Pesaro, Pesaro

63110

RECRUITING

Washington University School of Medicine, St Louis

64100

RECRUITING

C.H de la Côte Basque - Serviv, Bayonne

64180

RECRUITING

Instituto Mexicano del Seguro Social, Monterrey

64239

RECRUITING

Assuta MC, Tel Aviv

64460

RECRUITING

"Universidad Autonoma de Nuevo Leon (UANL) - Hospital Universitario Dr. Jose Eleuterio Gonzalez", Monterrey

66113

RECRUITING

Praxis für Hämatologie und Onkologie, Saarbrücken

73557

RECRUITING

Stauferklinikum Schwäbisch Gmünd, Mutlangen

74605

RECRUITING

Hospital das Clínicas UFG, Goiânia

75010

RECRUITING

Hôpital Saint-Louis, Paris

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

80054

RECRUITING

Centre Hospitalier Universitaire D'Amiens (Hopital Sud) - Hématologie Clinique, Amiens

81520

RECRUITING

Hospital Erasto Gaertner, Curitiba

81675

RECRUITING

Klinikum Rechts der Isar der Technischen Universität München Apotheke, München

90033

ACTIVE_NOT_RECRUITING

University of Southern California Norris Comprehensive Cancer Center, Los Angeles

90110

RECRUITING

Songklanagarind Hospital, Songkhla

90603

COMPLETED

Innovative Clinical Research Institute, Whittier

91120

RECRUITING

Hadassah Medical Organisation, Jerusalem

91910

RECRUITING

Sociedad de Metabolismo y Corazón S.C. - Oncology, Veracruz

94305

ACTIVE_NOT_RECRUITING

Stanford Cancer Center - Palo Alto, Stanford

94800

RECRUITING

Hopital Paul Brousse - Aphp Hôpitaux Universitaires Paris Su, Villejuif

95123

RECRUITING

Azienda Ospedaliero Universitaria Policlinico - Vittorio Emanuele, Catania

97239

COMPLETED

Oregon Health and Science University, Portland

150001

RECRUITING

Queen Mary Hospital, Hong Kong

167904

WITHDRAWN

Oncologic dispensary of Komi Republic, Syktyvkar

197089

WITHDRAWN

Saint-Petersburg SMU I.P.Pavlov, Saint Petersburg

200143

RECRUITING

Spitalul Clinic Municipal Filantropia Craiova, Craiova

300079

RECRUITING

Spitalul Clinic Municipal de Urgenta Timisoara, Timișoara

300329

RECRUITING

Oncomed, Timișoara

400015

RECRUITING

"Institutul Oncologic Prof. Dr. Ion Chiricuta", Cluj-Napoca

500283

RECRUITING

Cen Med de Diagn si Trat Amb NEOMED, Brasov

540136

RECRUITING

Spitalul Clinic Judetean de Urgenta Tg Mures, Târgu Mureş

644013

WITHDRAWN

Clinical oncological dispensary, Omsk

700483

RECRUITING

Institutul Regional de Oncologie Iasi, Iași

1321001

RECRUITING

Instituto COI São Paulo, São Paulo

1834111

RECRUITING

Ha'Emek Medical Center, Afula

6423906

RECRUITING

Tel Aviv Sourasky Medical Center - Oncology, Tel Aviv

7030000

RECRUITING

Assaf Harofeh Medical Center - Hematology, Ẕerifin

02215

WITHDRAWN

Dana-Farber Cancer Institute, Boston

S2000ORE

RECRUITING

Sanatorio de la Mujer, Rosario

Unknown

RECRUITING

Instituto Medico Alexander Fleming, Buenos Aires

RECRUITING

Royal Adelaide Hospital, Adelaide

RECRUITING

The Alfred Hospital, Melbourne

RECRUITING

Icon Cancer Center, South Brisbane

RECRUITING

University Multiprofile Hospital for Active Treatment Dr. Georgi Stranski, Pleven, Pleven

RECRUITING

University Multiprofile Hospital for Active Treatment Sveti Georgi, Plovdiv, Plovdiv

RECRUITING

Acibadem City Clinic Tokuda Hospital, Sofia, Sofia

RECRUITING

Specialized Hospital for Active Therapy of Hematological Disorders, Sofia

WITHDRAWN

University Multiprofile Hospital for Active Treatment Alexandrovska, Sofia, Sofia

RECRUITING

University Multiprofile Hospital for Active Treatment Saint Ivan Rilski, Sofia, Sofia

RECRUITING

Vseonecma fakultni nemocrince V Praze, New Town

RECRUITING

Centre Hospitalier Le Mans, Le Mans

RECRUITING

Centre Hospitalier Universitaire de Poitiers, Poitiers

ACTIVE_NOT_RECRUITING

Universitätsmedizin der Johannes Gutenberg Universität Mainz, Mainz

RECRUITING

Prince of Wales Hospital - Medicine, Shatin

RECRUITING

Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet, Budapest

RECRUITING

Assuta Ashdod University Hospital, Ashdod

RECRUITING

Carmel MC, Haifa

RECRUITING

"Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST IRCCS", Meldola

RECRUITING

SPZOZ MSWiA z Warminsko - Mazurskim Centrum Onkologii, Olsztyn

RECRUITING

Chang Gung Medical Foundation - ChiaYi Chang Gung Memorial Hospital - Chiayi Branch, Chiayi City

ACTIVE_NOT_RECRUITING

University Hospitals Birmingham NHS Foundation Trust, Birmingham

ACTIVE_NOT_RECRUITING

NHS Greater Glasgow and Clyde, Glasgow

ACTIVE_NOT_RECRUITING

Oxford University Hospitals NHS Foundation Trust, Oxford

X5016KEH

RECRUITING

Hospital Privado - Centro Medico de Cordoba - Oncology, Córdoba

60140-025

RECRUITING

Centro de oncologia Leonardo da Vinci, Fortaleza

17210-120

RECRUITING

Fundacao Doutor Amaral Carvalho, Jaú

90035-903

RECRUITING

Hospital de Clinicas de Porto Alegre - Centro de Pesquisa Clinica, Porto Alegre

90880-480

RECRUITING

Associação Educadora São Carlos AESC - Hospital Mãe de Deus - Centro de Pesquisa, Porto Alegre

01236-030

RECRUITING

Instituto de Ensino e Pesquisa São Lucas, São Paulo

01509-900

RECRUITING

Hospital A C Camargo - Fundacao Antonio Prudente, São Paulo

04502-001

RECRUITING

Instituto D'or de Pesquisa e Ensino, São Paulo

05403-000

RECRUITING

Hospital das Clínicas da Universidade de São Paulo, São Paulo

M5G 2M9

ACTIVE_NOT_RECRUITING

Princess Margaret Cancer Center, Toronto

500 05

RECRUITING

FN Hradec Kralove, Králová

779 00

WITHDRAWN

Fakultní Nemocnice Olomouc, Olomouc

49933 Cedex 09

RECRUITING

Center Hospitalier Universitaire d'Angers, Angers

30029 Cedex 9

ACTIVE_NOT_RECRUITING

Centre Hospitalier Universitaire de Nîmes, Nîmes

01307

RECRUITING

Gemeinschaftspraxis Haematologie - Onkologie - Hauptstelle, Dresden

RECRUITING

Technische Universität Dresden, Dresden

06120

RECRUITING

Universitätsklinikum Halle, Halle

07747

RECRUITING

Universitätsklinikum Jena, Jena

H-9700

RECRUITING

Markusovszky Egyetemi Oktatókórház, Szombathely

00168

RECRUITING

Policlinico Universitario Agostino Gemelli, Roma

LT-50161

RECRUITING

Hospital of Lithuanian University of Health Sciences Kaunas, Kaunas

53-439

RECRUITING

Dolnośląskie Centrum Transplantacji Komórkowych z Krajowym Bankiem Dawców Szpiku, Wroclaw

36-200

ACTIVE_NOT_RECRUITING

Szpital Specjalistyczny w Brzozowie Podkarpacki Ośrodek Onkologiczny im. Ks. B. Markiewicza, Brzozów

41-500

RECRUITING

Samodzielny Publiczny Zakład Opieki Zdrowotnej Zespół Szpitali Miejskich, Chorzów

86-168

RECRUITING

Szpital Uniwersytecki nr 2 im dr. Jana Biziela, Bydgoszcz

20-081

WITHDRAWN

Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie, Lublin

45-061

RECRUITING

Szpital Wojewódzki w Opolu, Opole

60-848

WITHDRAWN

Clinical Research Center Spółka z Ograniczoną Odpowiedzialnością Medic-R sp. k., Poznan

76-200

RECRUITING

Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Slupsku Sp. z o.o., Słupsk

3814-501

RECRUITING

H. Infante Dom Pedro. Centro Hospitalar do Baixo Vouga, Aveiro

4710-243

RECRUITING

Hospital de Braga, Braga

3000-075

RECRUITING

Instituto Português de Oncologia de Coimbra, Coimbra

1400-038

RECRUITING

Champalimaud Cancer Center, Lisbon

1495-005

RECRUITING

H. São Francisco Xavier-Centro Hospitalar Lisboa Ocidental, Lisbon

020125

RECRUITING

Spitalul Clinic Colentina, Bucharest

030171

RECRUITING

Spitalul Clinic Coltea, Bucharest

060201

RECRUITING

Medicover, Bucharest

Seongnam-si

RECRUITING

CHA Bundang Medical Center, CHA University, Seongnam-si

03080

RECRUITING

Seoul National University Hospital, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

08916

RECRUITING

Hospital Universitari Germans Trias i Pujol, Badalona

08035

RECRUITING

Hospital Universitario Vall d'Hebrón, Barcelona

07120

RECRUITING

Hospital Universitario Son Espases, Palma de Mallorca

06500

RECRUITING

Ankara University Faculty of Medicine, Ankara

RECRUITING

Gazi University Medical Faculty, Ankara

SE1 9RT

ACTIVE_NOT_RECRUITING

Guy's and Saint Thomas' NHS Foundation Trust, London

Sponsors
All Listed Sponsors
lead

Kartos Therapeutics, Inc.

INDUSTRY

NCT03662126 - KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment | Biotech Hunter | Biotech Hunter