Pembrolizumab and Reirradiation in Bevacizumab Naïve and Bevacizumab Resistant Recurrent Glioblastoma

PHASE2CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

September 28, 2018

Primary Completion Date

December 9, 2021

Study Completion Date

August 1, 2024

Conditions
Glioblastoma
Interventions
DRUG

Pembrolizumab

Pembrolizumab is a drug (an antibody) that may treat cancer by working with the immune system

DRUG

Bevacizumab

"Bevacizumab (also known as Avastin) is designed to prevent or slow down the growth of cancer cells by blocking the growth of blood vessels."

RADIATION

Re-irradiation

Radiotherapy destroys cancer cells using radiation aimed at a cancer from a machine

Trial Locations (5)

10032

Columbia University / Herbert Irving Comprehensive Cancer Center, New York

19104

Hospital of the University of Pennsylvania, Abramson Cancer Center, Philadelphia

02115

Beth Israel Deaconess Medical Center, Boston

Dana Farber Cancer Institute, Boston

02214

Massachusetts General Hospital, Boston

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Dana-Farber Cancer Institute

OTHER

NCT03661723 - Pembrolizumab and Reirradiation in Bevacizumab Naïve and Bevacizumab Resistant Recurrent Glioblastoma | Biotech Hunter | Biotech Hunter