A Study to Compare Chemotherapy Alone Versus Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Therapy After Surgery With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle Invasive Bladder Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

855

Participants

Timeline

Start Date

November 6, 2018

Primary Completion Date

November 17, 2025

Study Completion Date

December 30, 2027

Conditions
Urinary Bladder NeoplasmsMuscle-Invasive Bladder Cancer
Interventions
BIOLOGICAL

Nivolumab

Specified dose on specified days

DRUG

Gemcitabine

Specified dose on specified days

DRUG

Cisplatin

Specified dose on specified days

Trial Locations (172)

0

Local Institution - 0201, Colombia

1023

Local Institution - 0087, Auckland

1090

Local Institution - 0012, Vienna

1118

Local Institution - 0151, Ciudad Autonoma Buenos Aires

1200

Local Institution - 0060, Brussels

1280

Local Institution - 0049, Ciudad Autónoma de Buenos Aires

1426

Local Institution - 0051, Capital Federal

1478

Local Institution - 0132, Lorenskog

1714

Local Institution - 0158, Grålum

2065

Local Institution - 0043, St Leonards

2109

Local Institution - 0157, Macquarie University

2605

Local Institution - 0131, Garran

2610

Local Institution - 0062, Wilrijk

2747

Local Institution - 0130, Kingswood

3084

Local Institution - 0037, Heidelberg

3500

Local Institution - 0091, Krems

4020

Local Institution - 0011, Linz

5006

Local Institution - 0143, North Adelaide

6150

Local Institution - 0038, Murdoch

8011

Local Institution - 0089, Christchurch

9000

Local Institution - 0063, Ghent

9020

Local Institution - 0090, Klagenfurt

10065

Local Institution - 0047, New York

10408

Local Institution - 0137, Goyang-si

11042

Local Institution - 0069, Lake Success

11217

Local Institution - 0139, Taipei

12208

Local Institution - 0029, Albany

12462

Local Institution - 0194, Chaïdári

13273

Local Institution - 0075, Marseille

13496

Local Institution - 0215, Seongnam-si

13620

Local Institution - 0203, Seongnam-si

20133

Local Institution - 0032, Milan

20251

Local Institution - 0146, Turku

21044

Local Institution - 0181, Columbia

23040

Local Institution - 0160, La Paz

23502

Local Institution - 0023, Norfolk

23538

Local Institution - 0084, Lübeck

25000

Local Institution - 0101, Besançon

27003

Local Institution - 0113, Lugo

28007

Local Institution - 0111, Madrid

28017

Local Institution - 0105, Colima

28033

Local Institution - 0112, Madrid

28041

Local Institution - 0114, Madrid

29010

Local Institution - 0156, Málaga

29425

Local Institution - 0189, Charleston

29609

Local Institution - 0202, Brest

30342

Local Institution - 0144, Atlanta

31059

Local Institution - 0003, Toulouse

32503

Local Institution - 0036, Pensacola

33076

Local Institution - 0217, Bordeaux

33521

Local Institution - 0145, Tampere

33612

Local Institution - 0004, Tampa

34298

Local Institution - 0200, Montpellier

35128

Local Institution - 0033, Padua

37075

Local Institution - 0080, Göttingen

37232

Local Institution - 0007, Nashville

38043

Local Institution - 0206, La Tronche

39120

Local Institution - 0079, Magdeburg

41012

Local Institution - 0065, Modena

41013

Local Institution - 0109, Seville

41404

Local Institution - 0218, Daegu

44195

Local Institution - 0191, Cleveland

44625

Local Institution - 0013, Herne

44805

Local Institution - 0188, Saint-Herblain

45050

Local Institution - 0102, Zapopan

45136

Local Institution - 0081, Essen

47014

Local Institution - 0193, Meldola (FC)

48108

Local Institution - 0220, Busan

49100

Local Institution - 0198, Angers

50612

Local Institution - 0208, Gyeongsangnam-do

52074

Local Institution - 0078, Aachen

52621

Local Institution - 0067, Ramat Gan

54292

Local Institution - 0085, Trier

55131

Local Institution - 0100, Mainz

55404

Local Institution - 0025, Minneapolis

55455

Local Institution - 0129, Minneapolis

56126

Local Institution - 0034, Pisa

60590

Local Institution - 0086, Frankfurt am Main

60637

Local Institution - 0005, Chicago

61615

Local Institution - 0006, Peoria

63000

Local Institution - 0199, Clermont-Ferrand

64460

Local Institution - 0056, Monterrey

67091

Local Institution - 0002, Strasbourg

68130

Local Institution - 0183, Omaha

69495

Local Institution - 0020, Pierre Benite Cedax

70124

Local Institution - 0064, Bari

75014

Local Institution - 0163, Paris

78731

Local Institution - 0030, Austin

80054

Local Institution - 0205, Amiens

81675

Local Institution - 0082, München

84101

Local Institution - 0068, Beersheba

85711

Local Institution - 0022, Tucson

89169

Local Institution - 0024, Las Vegas

90419

Local Institution - 0016, Nuremberg

94010

Local Institution - 0204, Créteil

95817

UC Davis Comprehensive Cancer Center, Sacramento

97223

Local Institution - 0028, Tigard

99028

Local Institution - 0015, Erfurt

100229

Local Institution - 0141, Taipei

168583

Local Institution - 0154, Singapore

194044

Local Institution, Saint Petersburg

197758

Local Institution, Saint Petersburg

200542

Local Institution - 0076, Craiova

230003

Local Institution - 0103, Montería

400015

Local Institution - 0219, Cluj-Napoca

407219

Local Institution - 0165, Taichung

681004

Local Institution - 0104, Bucaramanga

833401

Local Institution - 0135, Kaohsiung City

1058470

Local Institution - 0178, Minato-ku

3058576

Local Institution - 0179, Tsukuba

3109601

Local Institution - 0066, Haifa

3501298

Local Institution - 0176, Hidaka-shi

6423906

Local Institution - 0196, Tel Aviv

8330024

Local Institution - 0053, Santiago

8380456

Local Institution - 0052, Santiago

8420383

Local Institution - 0210, Santiago

9518520

Local Institution - 0168, Niigata

90610000

Local Institution - 0097, Porto Alegre

80120-4413

Local Institution - 0021, Littleton

02114

Local Institution - 0009, Boston

02215

Local Institution - 0166, Boston

Local Institution - 0209, Boston

68198-6840

Local Institution - 0001, Omaha

60130-241

Local Institution - 0094, Fortaleza

35160-158

Local Institution - 0099, Ipatinga

98700-000

Local Institution - 0092, Ijuí

90035-001

Local Institution - 0212, Porto Alegre

14780-070

Local Institution - 0098, Barretos

17210-080

Local Institution - 0095, Jaú

15090-000

Local Institution - 0093, São José do Rio Preto

20231-050

Local Institution - 0164, Rio de Janeiro

01221-020

Local Institution - 0214, São Paulo

V1Y 5L3

Local Institution - 0159, Kelowna

M2K 1E1

Local Institution - 0182, North York

G7H 5H6

Local Institution - 0192, Chicoutimi

H3T 1M5

Local Institution - 0190, Montreal

Unknown

Local Institution - 0054, Santiago

00029

Local Institution - 0148, Helsinki

06189

Local Institution - 0074, Nice

07747

Local Institution - 0010, Jena

155 62

Local Institution - 0195, Athens

411 10

Local Institution - 0031, Larissa

00168

Local Institution - 0035, Roma

485-8520

Local Institution - 0186, Komaki

0030804

Local Institution - 0184, Sapporo

060-8543

Local Institution - 0177, Sapporo

0608604

Local Institution - 0185, Sapporo

761-0793

Local Institution - 0171, Kita-gun

222-0036

Local Institution - 0169, Yokohama

589-8511

Local Institution - 0173, Sayama

569-8686

Local Institution - 0175, Takatsuki

431-3192

Local Institution - 0170, Hamamatasu

160-8582

Local Institution - 0172, Shinjuku-ku

812-8582

Local Institution - 0174, Fukuoka

606-8507

Local Institution - 0180, Kyoto

1066 CX

Local Institution - 0070, Amsterdam

9713 GZ

Local Institution - 0072, Groningen

6162 BG

Local Institution - 0073, Sittard-Geleen

0379

Local Institution - 0133, Oslo

1649-035

Local Institution - 0153, Lisbon

4200-072

Local Institution - 0152, Porto

022328

Local Institution - 0058, Sector 2

02841

Local Institution - 0140, Seoul

03080

Local Institution - 0136, Seoul

05505

Local Institution - 0211, Seoul

06351

Local Institution - 0138, Seoul

CM1 7ET

Local Institution - 0128, Chelmsford

YO31 8HE

Local Institution - 0127, York

G12 0YN

Local Institution - 0122, Glasgow

LA1 4RP

Local Institution - 0117, Lancaster

SE1 9RT

Local Institution - 0121, London

OX3 7LE

Local Institution - 0124, Oxford

Sponsors
All Listed Sponsors
collaborator

Ono Pharmaceutical Co. Ltd

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY