Reversal of Residual Neuromuscular Blockade at Train-of-four Ratio 0.3 With Sugammadex and Neostigmine

CompletedOBSERVATIONAL
Enrollment

121

Participants

Timeline

Start Date

July 26, 2018

Primary Completion Date

June 28, 2019

Study Completion Date

June 30, 2019

Conditions
Neuromuscular Blockade
Interventions
DRUG

Sugammadex

"At the end of surgical procedure at a depth of neuromuscular blockade at the reappearance of train-of-four 0.3, single intravenous injection of either :~Sugammadex 0.125 mg/kg (sugammadex 0.125) Sugammadex 0.25 mg/kg (sugammadex 0.25) Sugammadex 0.5 mg/kg (sugammadex 0.5) Sugammadex 1.0 mg/kg (sugammadex 1.0) Sugammadex 2.0 mg/kg (sugammadex 2.0)"

DRUG

Neostigmine

"At the end of surgical procedure at a depth of neuromuscular blockade at the reappearance of train-of-four 0.3, single intravenous injection of either :~Neostigmine 10 µg/kg (Neostigmine 10) Neostigmine 25 µg/kg (Neostigmine 25) Neostigmine 40 µg/kg (Neostigmine 40) Neostigmine 55 µg/kg (Neostigmine 55) Neostigmine 70 µg/kg (Neostigmine 70)~Atropine will be administered with Neostigmine at a half dose of Neostigmine administered through an intravenous line with brisk flow."

DRUG

Saline 0.9%

At the end of surgical procedure at a depth of neuromuscular blockade at the reappearance of train-of-four 0.3, single intravenous injection of saline 0.9%.

Trial Locations (1)

510010

Guangzhou Military Region General Hospital, Department of Anesthesiology, Guangzhou

All Listed Sponsors
lead

Guangzhou General Hospital of Guangzhou Military Command

OTHER

NCT03656614 - Reversal of Residual Neuromuscular Blockade at Train-of-four Ratio 0.3 With Sugammadex and Neostigmine | Biotech Hunter | Biotech Hunter