Using Imaging to Assess Effects of THC on Brain Activity

NACompletedINTERVENTIONAL
Enrollment

316

Participants

Timeline

Start Date

November 5, 2018

Primary Completion Date

January 21, 2021

Study Completion Date

January 21, 2021

Conditions
Intoxication AlcoholIntoxication THCIntoxication Combined Alcohol THC
Interventions
DRUG

Dronabinol

Dronabinol at physician determined doses of 10-80mg designed to produce intoxication.

DRUG

Ethanol

Oral Ethanol, dosed to obtain a breath alcohol concentration (BrAC) of approximately 0.05 BrAC (equal to 1-2 standard drinks).

DRUG

Placebo dronabinol

Identical in appearance to active dronabinol (overencapsulation of both active and placebo dronabinol)

DRUG

Placebo ethanol

Placebo ethanol will consist of diet soda used in the active ethanol condition with 0.25ml ethanol floated on top to provide the odor of ethanol and blind the study drug.

Trial Locations (1)

02114

Center for Addiction Medicine, Massachusetts General Hospital, Dept. of Psychiatry, Boston

All Listed Sponsors
collaborator

National Institute on Drug Abuse (NIDA)

NIH

lead

Massachusetts General Hospital

OTHER

NCT03655717 - Using Imaging to Assess Effects of THC on Brain Activity | Biotech Hunter | Biotech Hunter