Pharmacogenetics Use For Further Treatment Improvement in childreN

NACompletedINTERVENTIONAL
Enrollment

102

Participants

Timeline

Start Date

June 12, 2018

Primary Completion Date

October 18, 2023

Study Completion Date

October 18, 2023

Conditions
Asthma in Children
Interventions
GENETIC

ADRB2-genotype guided treatment

This intervention assesses whether ADRB2 genotype-guided treatment leads to better asthma control after 3 months compared to usual care in children who are uncontrolled despite adherent and adequate use of ICS.

OTHER

Randomisation

In the control arm, children will be randomised over double dose ICS or ICS+LABA instead of treatment according to their genotype.

Trial Locations (21)

B-2650

Universitair Ziekenhuis Antwerpen, Edegem

9202NN

Nij Smellinghe, Drachten

6815 AD

Rijnstate, Arnhem

6525GA

RadboudUMC, Nijmegen

6532 SZ

Canisius Wilhelmina Ziekenhuis, Nijmegen

4818CK

Amphia ziekenhuis, Breda

5623 EJ

Catharina ziekenhuis, Eindhoven

1081 HV

VUmc locatie Boelelaan, Amsterdam

1105AZ

Academic Medical Center, Department of Respiratory Disease, Amsterdam-Zuidoost

0031232245730

Spaarne Gasthuis, Hoofddorp

8934AD

Medisch Centrum Leeuwarden, Leeuwarden

2625 AD

Reinier de Graaf Gasthuis, Delft

3015CN

Erasmus Medical Center, Rotterdam

3045 PM

Sint Franciscus Gasthuis, Rotterdam

3079 DZ

Maasstadziekenhuis, Rotterdam

2545 AA

Haga ziekenhuis, The Hague

7512 KZ

Medisch Spectrum Twente, Enschede

9700RB

University Medical Center Groningen, Groningen

9728NT

Martini ziekenhuis, Groningen

1213 XZ

Tergooi ziekenhuis, Hilversum

CH-8032

Kinderspital, Zurich

All Listed Sponsors
collaborator

Dutch Lung Foundation

UNKNOWN

lead

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

OTHER

NCT03654508 - Pharmacogenetics Use For Further Treatment Improvement in childreN | Biotech Hunter | Biotech Hunter