1,437
Participants
Start Date
December 10, 2018
Primary Completion Date
December 14, 2023
Study Completion Date
July 31, 2024
Dexmedetomidine
"Patients will commence intravenous infusion of open-label study drug according to a weight-based dose regimen as early as possible post-randomisation, and within a maximum of two hours.~Bedside clinical staff will transition patients to achieve sedation with the allocated α2-agonist agent as quickly as clinically feasible and safe, to replicate the way these drugs would be used in routine practice. Additional opiate will be used for analgesia using clinical judgement. Once established, additional propofol will only be used when the maximum α2-agonist dose is reached or because cardiovascular or other side-effects limit dose escalation."
Clonidine
"Patients will commence intravenous infusion of open-label study drug according to a weight-based dose regimen as early as possible post-randomisation, and within a maximum of two hours.~Bedside clinical staff will transition patients to achieve sedation with the allocated α2-agonist agent as quickly as clinically feasible and safe, to replicate the way these drugs would be used in routine practice. Additional opiate will be used for analgesia using clinical judgement. Once established, additional propofol will only be used when the maximum α2-agonist dose is reached or because cardiovascular or other side-effects limit dose escalation."
Propofol
Patients will continue to receive intravenous propofol according to current usual care.
Belfast Health & Social Care Trust, Belfast
South Eastern Health and Social Trust, Belfast
University Hospitals Birmingham NHS Foundation Trust, Birmingham
Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool
North Bristol NHS Trust, Bristol
University Hospitals Bristol NHS Foundation Trust, Bristol
Cambridge University Hospitals NHS Foundation Trust, Cambridge
Cardiff and Vale University Health Board, Cardiff
Countess of Chester Hospital NHS Foundation Trust, Chester
The Dudley Group NHS Foundation Trust, Dudley
NHS Dumfries and Galloway, Dumfries
NHS Lothian, Edinburgh
Medway NHS Foundation Trust, Gillingham
NHS Greater Glasgow and Clyde, Glasgow
Harrogate and District NHS Trust, Harrogate
Wye Valley NHS Trust, Hereford
The Queen Elizabeth Hospital Kings Lynn NHS Foundation Trust, Kings Lynn
Leeds Teaching Hospitals NHS Trust, Leeds
University Hospitals of Leicester, Leicester
Lewisham and Greenwich NHS Trust, Lewisham
Aintree University Hospital Foundation Trust, Liverpool
Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool
Guys and St Thomas NHS Foundation Trust, London
Imperial College Healthcare NHS Trust, London
King's College Hospital NHS Foundation Trust, London
St George's University Hospitals NHS Foundation Trust, London
The Royal Marsden NHS Foundation Trust, London
University College London Hospitals NHS Foundation Trust, London
Manchester University Foundation Trust, Manchester
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle
Aneurin Bevan University Health Board, Newport
Nottingham University Hospitals NHS Trust, Nottingham
Oxford University Hospitals NHS Foundation Trust., Oxford
Poole Hospitals NHS Foundation Trust, Poole
University Hospital Southampton NHSFT, Southampton
North Tees and Hartlepool NHS Foundation Trust, Stockton-on-Tees
Taunton and Somerset NHS Foundation Trust, Taunton
West Hertfordshire Hospitals NHS Trust, Watford
West Hertfordshire Hospitals NHS Trust
OTHER
Queen's University, Belfast
OTHER
The University of Queensland
OTHER
University Hospital of Wales
OTHER
Edinburgh Napier University
OTHER
King's College London
OTHER
University of Warwick
OTHER
University of Manchester
OTHER
Royal Surrey County Hospital NHS Foundation Trust
OTHER
University College, London
OTHER
NHS Lothian
OTHER_GOV
Imperial College London
OTHER
University of Cambridge
OTHER
University of Edinburgh
OTHER