First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System (CNS) Metastases

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

492

Participants

Timeline

Start Date

October 29, 2018

Primary Completion Date

July 12, 2022

Study Completion Date

July 12, 2022

Conditions
Non-small Cell Lung CancerEGFR Gene MutationBrain Metastases
Interventions
DRUG

AZD3759

AZD3759 200mg PO BID.

DRUG

Erlotinib

SoC EGFRTKI Erlotinib 150 mg PO Q.D

DRUG

Gefitinib

SoC EGFRTKI Gefitinib 250 mg PO Q.D

Trial Locations (58)

100

Taiwan site, Taipei

333

Taiwan site, Taoyuan District

407

Taiwan site, Taichung

704

Taiwan site, Tainan City

16247

Korea site, Gyeonggi-do

16499

Korea site, Suwon

21565

Korea site, Incheon

28644

Korea Site, Jungbuk

42415

Korea site, Daegu

44033

Korea site, Ulsan

52727

Korea site, Gyeongsang

100021

China site, Beijing

100071

China site, Beijing

100142

China site, Beijing

100730

China site, Beijing

130012

China site, Changchun

130021

China site, Changchun

150081

China site, Haerbin

200030

China site, Shanghai

200032

China site, Shanghai

210002

China site, Nanjing

210009

China site, Nanjing

214062

China site, Wuxi

215004

China site, Suzhou

221002

China site, Xuzhou

225001

China site, Yangzhou

230001

China site, Hefei

250117

China site 0123, Jinan

261000

China site, Weifang

264000

China site, Yantai

276000

China site, Linyi

300052

China site, Tianjin

308433

Singapore site, Singapore

310003

China site, Hangzhou

310022

China site, Hangzhou

311100

China site, Hangzhou

350014

China site, Fuzhou

361003

China site, Xiamen

400030

China site, Chongqing

400037

China site, Chongqing

400042

China site, Chongqing

410013

China site, Changsha

430022

China site, Wuhan

430030

China site, Wuhan

430079

China site, Wuhan

443003

China site, Yichang

450008

China site, Zhengzhou

450052

China site, Zhengzhou

510080

China site, Guangzhou

510180

China site, Guangzhou

610041

China site, Chengdu

650118

China site, Kunming

710061

China site, Xi'an

03080

Korea Site, Seoul

05368

Korea site, Seoul

06351

Korea Site, Seoul

06591

Korea site, Seoul

07061

Korea site, Seoul

All Listed Sponsors
lead

Alpha Biopharma (Jiangsu) Co., Ltd.

INDUSTRY

NCT03653546 - First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System (CNS) Metastases | Biotech Hunter | Biotech Hunter