Exercise and Nutrition for Healthy AgeiNg

NARecruitingINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

February 12, 2018

Primary Completion Date

December 31, 2024

Study Completion Date

June 30, 2025

Conditions
Sarcopenia
Interventions
BEHAVIORAL

Home-based training program

Exercise intervention: During the intervention period, the participant will perform the optimized and personally adapted Otago Exercise Program (OEP). The participant is encouraged to perform the resistance exercises three times a week with a rest day in between. The participant is advised to perform the exercises in close temporal proximity to one of the moments of the intake of the protein supplement. The participant will also follow a walking plan in which he or she needs to walk 30 minutes twice a week. These 30 minutes can be broken down to three 10-minute walks throughout the day. During the follow-up period, participants may continue the OEP, but no personal encouragement will be given during this period.

DIETARY_SUPPLEMENT

High-quality protein supplement

The participant will receive an individually adapted protein supplement to achieve the recommend total (usual diet and supplements) daily intake of 1.5 g/protein/kg for frail elderly. This will be realized by adding an individualized amount (g) of protein powder during breakfast, lunch, dinner or snack between meals, or before breakfast or after dinner, based on the subjects' food intake assessed by a food diary. The participant will take the protein supplement from 5 days before the start of the intervention. The protein powder is commercially available and consists of 4.5g protein/5g powder. During the follow-up, no protein supplement is added.

DIETARY_SUPPLEMENT

Omega-3 fatty acid

Four weeks before the start of the intervention, the participant will start the intake of 1 omega-3 capsule providing in total 500 mg EPA and 450 mg DHA until the end of the intervention. He or she has to take the supplement once daily at a chosen time. During the follow-up, no omega-3 supplement will be given.

DRUG

Placebo protein powder

Isocaloric maltodextrin powder. Amount based on food diary.

DRUG

Placebo omega-3

Peanut oil soft gel capsules. 1g/ capsule. 1 capsule/day

Trial Locations (1)

3000

RECRUITING

Gerontology and Geriatrics, Department of Public Health and Primary Care, KU Leuven, Leuven

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

KU Leuven

OTHER

collaborator

VISTA-Life

UNKNOWN

collaborator

Nestle Health Science

INDUSTRY

lead

Universitaire Ziekenhuizen KU Leuven

OTHER