BEtablocker Treatment After Acute Myocardial Infarction in Patients Without Reduced Left Ventricular Systolic Function

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

2,895

Participants

Timeline

Start Date

October 1, 2018

Primary Completion Date

April 4, 2025

Study Completion Date

December 10, 2035

Conditions
Acute Myocardial InfarctionNon-ST Elevation Myocardial InfarctionST Elevation Myocardial Infarction
Interventions
OTHER

Non-betablocker

No betablocker will be administered. Patients randomized to no beta-blockade will be discouraged to use beta-blockade as long as there is no other indication than strictly secondary prevention after myocardial infarction. Any other treatment or management is to be given as per usual care.

DRUG

Betablocker

"A betablocker will be administered. To reflect contemporary management, for which this study is designed to test, there will not be a defined minimum dosage. The type and dose of BB will be left at the discretion of the PI. Generic drug and accepted dosages will be:~* Metoprolol succinate up to a total dose of 200mg daily~* Bisoprolol up to a total dose of 10mg daily~* Carvedilol up to a total dose of 50mg daily~The treating physician will be encouraged to aim for an equipotent dose of 100 mg metoprolol succinate or higher. Any other treatment or management is to be given as per usual care."

Trial Locations (20)

Unknown

Sørlandet Sykehus, Arendal

Haukeland Universitetssykehus, Bergen

Nordlandssykehuset HF Bodø, Bodø

Drammen Hospital, Drammen

Sykehuset Østfold Kalnes, Fredrikstad

Sykehuset Innlandet HF, Gjøvik Sykehus, Gjøvik

Sykehuset Innlandet Hamar, Hamar

Vestre Viken HF, Ringerike Sykehus, Hønefoss

Sykehuset Innlandet Lillehammer, Lillehammer

AHUS, Lørenskog

LHL Gardermoen, Lørenskog

Diakonhjemmet Sykehus, Oslo

Lovisenberg Diakonale Sykehus, Oslo

Oslo University Hospital Rikshospitalet, Dept.of Cardiology, Oslo

Oslo University Hospital Ullevaal, Dept. of Cardiology, Oslo

Vestre Viken HF, Bærum Sykehus, Sandvika

Stavanger Universitetssjukehus, Stavanger

Universitetssykehuset Nord-Norge, UNN, Tromsø

St. Olavs University Hospital, Trondheim

Vestfold hospital, Tønsberg

All Listed Sponsors
collaborator

Vestre Viken Hospital Trust

OTHER

collaborator

The Hospital of Vestfold

OTHER

collaborator

University of Oslo

OTHER

collaborator

Helse Stavanger HF

OTHER_GOV

collaborator

Haukeland University Hospital

OTHER

collaborator

St. Olavs Hospital

OTHER

collaborator

University Hospital of North Norway

OTHER

collaborator

Sorlandet Hospital HF

OTHER_GOV

collaborator

Norwegian University of Science and Technology

OTHER

collaborator

Sykehuset Innlandet HF

OTHER

collaborator

Nordlandssykehuset HF

OTHER

collaborator

Lovisenberg Diakonale Hospital

OTHER

collaborator

Diakonhjemmet Hospital

OTHER

collaborator

Ostfold Hospital Trust

OTHER

lead

Oslo University Hospital

OTHER